Ube2z ubiquitin-conjugating enzyme E2Z [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2zprovided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2Zprovided by MGI
Primary source: MGI:MGI:1343160
See related: Ensembl:ENSMUSG00000014349 AllianceGenome:MGI:1343160
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D11Moh35; C030047H17Rik
Summary: Enables ubiquitin conjugating enzyme activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human UBE2Z (ubiquitin conjugating enzyme E2 Z). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 37.8), placenta adult (RPKM 30.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.28 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (95938257..95956190, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (96047431..96065364, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G38041 (e-PCR)
- UniSTS:105029

G38042 (e-PCR)
- UniSTS:105030

AW049199 (e-PCR)
- UniSTS:180301

NoName (e-PCR)
- UniSTS:236709

D11Moh21 (e-PCR), detects polymorphism
- UniSTS:141773

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 Z

Names: E2 ubiquitin-conjugating enzyme Z; uba6-specific E2 conjugating enzyme 1; ubiquitin carrier protein Z; ubiquitin-conjugating enzyme E2Z (putative); ubiquitin-protein ligase Z; use1

NP_758504.3

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172300.3 → NP_758504.3 ubiquitin-conjugating enzyme E2 Z

See identical proteins and their annotated locations for NP_758504.3

Status: VALIDATED

Source sequence(s)

AK153328, AL603682, CA317477

Consensus CDS

CCDS36289.1

UniProtKB/Swiss-Prot

A2A6M3, Q3TFZ8, Q3U618, Q3UE37, Q7TMY6, Q8BVL2, Q9DAU4

Related

ENSMUSP00000098097.5, ENSMUST00000100528.5

Conserved Domains (1) summary

cd00195
Location:105 → 223

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...