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    Gon4l gon-4 like [ Mus musculus (house mouse) ]

    Gene ID: 76022, updated on 8-May-2024

    Summary

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    Official Symbol
    Gon4lprovided by MGI
    Official Full Name
    gon-4 likeprovided by MGI
    Primary source
    MGI:MGI:1917579
    See related
    Ensembl:ENSMUSG00000054199 AllianceGenome:MGI:1917579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA387005; 1500041I23Rik; 2610100B20Rik; 3632445O20Rik; 5430404N14Rik
    Summary
    Enables transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within B cell differentiation. Located in nucleus. Used to study salivary gland cancer. Orthologous to several human genes including GON4L (gon-4 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.1), CNS E14 (RPKM 12.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gon4l in Genome Data Viewer
    Location:
    3 F1; 3 39.0 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88742531..88817406)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88835207..88910099)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4551 Neighboring gene gon-4-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3444 Neighboring gene synaptotagmin XI Neighboring gene STARR-seq mESC enhancer starr_08218 Neighboring gene RIKEN cDNA 1500004A13 gene Neighboring gene STARR-seq mESC enhancer starr_08219 Neighboring gene STARR-positive B cell enhancer ABC_E10195 Neighboring gene STARR-seq mESC enhancer starr_08220 Neighboring gene predicted gene, 23054 Neighboring gene STARR-seq mESC enhancer starr_08221 Neighboring gene predicted gene, 40091 Neighboring gene predicted gene, 53242 Neighboring gene nuclear encoded rRNA 5S 197 Neighboring gene misato 1, mitochondrial distribution and morphology regulator Neighboring gene death associated protein 3 Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene predicted gene, 26465

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcriptional regulator GON4L is required for viability and hematopoiesis in mice. Colgan DF, et al. Exp Hematol, 2021 Jun. PMID 33864850, Free PMC Article
    2. Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division. Barr JY, et al. J Immunol, 2017 May 15. PMID 28381640, Free PMC Article
    3. The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. Lu P, et al. J Exp Med, 2010 Jul 5. PMID 20530203, Free PMC Article
    4. The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. Simons AL, et al. Lab Invest, 2013 Jun. PMID 23608756, Free PMC Article
    5. The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. Lu P, et al. J Biol Chem, 2011 May 20. PMID 21454521, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.
      Title: The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.
    2. Newly identified Gon4l/Udu-interacting proteins implicate novel functions.
      Title: Newly identified Gon4l/Udu-interacting proteins implicate novel functions.
    3. findings indicate that GON4L is essential for cell cycle progression and division during the early stages of B cell development
      Title: Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division.
    4. mice with recessive mutation spontaneously developed carcinomas with myoepithelial and basaloid differentiation in salivary glands with an incidence of approximately 25%
      Title: The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation.
    5. the Gon4l protein is required for B lymphopoiesis and may function to regulate gene expression during this process.
      Title: The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GON-4-like protein
    Names
    GON-4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242372.2 → NP_001229301.1  GON-4-like protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC127377
      UniProtKB/TrEMBL
      Q32NZ8
      Conserved Domains (2) summary
      cd12202
      Location:2161 → 2226
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1671 → 1716
      PAH; Paired amphipathic helix repeat

    2. NM_001408383.1 → NP_001395312.1  GON-4-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127377

    3. NM_027389.4 → NP_081665.2  GON-4-like protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC127377
      Consensus CDS
      CCDS50954.1
      UniProtKB/TrEMBL
      E9Q507, F8WGY9, Q32NZ8
      Related
      ENSMUSP00000103122.3, ENSMUST00000107498.9
      Conserved Domains (2) summary
      cd12202
      Location:2144 → 2209
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      pfam02671
      Location:1654 → 1699
      PAH; Paired amphipathic helix repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88742531..88817406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163384.1 → XP_036019277.1  GON-4-like protein isoform X1

      UniProtKB/TrEMBL
      Q32NZ8
      Conserved Domains (3) summary
      cd12202
      Location:2163 → 2228
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:992 → 1258
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1672 → 1717
      PAH; Paired amphipathic helix repeat

    2. XM_036163387.1 → XP_036019280.1  GON-4-like protein isoform X4

      UniProtKB/TrEMBL
      Q32NZ8
      Conserved Domains (3) summary
      cd12202
      Location:2154 → 2219
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:983 → 1249
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1663 → 1708
      PAH; Paired amphipathic helix repeat

    3. XM_036163385.1 → XP_036019278.1  GON-4-like protein isoform X2

      UniProtKB/Swiss-Prot
      E9Q5N3, Q80TB4, Q91YI9, Q9DB00
      UniProtKB/TrEMBL
      Q32NZ8
      Related
      ENSMUSP00000080397.9, ENSMUST00000081695.15
      Conserved Domains (3) summary
      cd12202
      Location:2162 → 2227
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:992 → 1258
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1672 → 1717
      PAH; Paired amphipathic helix repeat

    4. XM_036163386.1 → XP_036019279.1  GON-4-like protein isoform X3

      UniProtKB/TrEMBL
      Q32NZ8
      Conserved Domains (3) summary
      cd12202
      Location:2154 → 2219
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:984 → 1250
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1664 → 1709
      PAH; Paired amphipathic helix repeat

    5. XM_036163388.1 → XP_036019281.1  GON-4-like protein isoform X5

      UniProtKB/TrEMBL
      Q32NZ8
      Conserved Domains (3) summary
      cd12202
      Location:2153 → 2218
      CASP8AP2; Caspase 8-associated protein 2 myb-like domain
      PHA03247
      Location:983 → 1249
      PHA03247; large tegument protein UL36; Provisional
      pfam02671
      Location:1663 → 1708
      PAH; Paired amphipathic helix repeat

    RNA

    1. XR_004941411.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB00.3 GenPept UniProtKB/Swiss-Prot:Q9DB00

    Gene LinkOut

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