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    Ablim3 actin binding LIM protein family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 319713, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ablim3provided by MGI
    Official Full Name
    actin binding LIM protein family, member 3provided by MGI
    Primary source
    MGI:MGI:2442582
    See related
    Ensembl:ENSMUSG00000032735 AllianceGenome:MGI:2442582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D930036B08Rik
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in glutamatergic synapse. Is active in synapse. Is expressed in several structures, including central nervous system; heart; neural retina; skeletal muscle tissue; and trigeminal nerve. Orthologous to human ABLIM3 (actin binding LIM protein family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 16.1), CNS E18 (RPKM 14.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ablim3 in Genome Data Viewer
    Location:
    18 E1; 18 34.77 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61932463..62044956, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61799392..61911885, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500015A07 gene Neighboring gene GrpE-like 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E7594 Neighboring gene actin filament associated protein 1-like 1 Neighboring gene predicted gene, 41748 Neighboring gene STARR-seq mESC enhancer starr_44765 Neighboring gene predicted gene, 35919 Neighboring gene STARR-positive B cell enhancer ABC_E10996 Neighboring gene predicted gene, 35720 Neighboring gene SH3 domain and tetratricopeptide repeats 2 Neighboring gene STARR-seq mESC enhancer starr_44766

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. abLIM3 is a novel component of adherens junctions with actin-binding activity. Matsuda M, et al. Eur J Cell Biol, 2010 Nov. PMID 20709423
    2. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. Barrientos T, et al. J Biol Chem, 2007 Mar 16. PMID 17194709
    3. SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis. Liu CF, et al. Development, 2018 Jul 18. PMID 30021842, Free PMC Article
    4. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Cao J, et al. Nat Cell Biol, 2012 Jun 10. PMID 22684256
    5. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABLIM-2 and -3 associate with STARS and directly bind F-actin
      Title: Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0843, MGC69876

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actin-binding LIM protein 3
    Names
    abLIM-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164491.1 → NP_001157963.1  actin-binding LIM protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001157963.1

      Status: VALIDATED

      Source sequence(s)
      AC091677, BC060275, CF171696
      Consensus CDS
      CCDS37839.1
      UniProtKB/Swiss-Prot
      Q52KR1, Q69ZX8, Q6PAI7
      Related
      ENSMUSP00000125836.2, ENSMUST00000166783.3
      Conserved Domains (6) summary
      smart00153
      Location:647 → 682
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 645
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    2. NM_001360868.1 → NP_001347797.1  actin-binding LIM protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091677, AC125157
      Conserved Domains (6) summary
      smart00153
      Location:614 → 649
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 612
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    3. NM_198649.3 → NP_941051.2  actin-binding LIM protein 3 isoform 1

      See identical proteins and their annotated locations for NP_941051.2

      Status: VALIDATED

      Source sequence(s)
      AC091677, BC094229
      Consensus CDS
      CCDS37839.1
      UniProtKB/Swiss-Prot
      Q52KR1, Q69ZX8, Q6PAI7
      Related
      ENSMUSP00000041243.9, ENSMUST00000049378.15
      Conserved Domains (6) summary
      smart00153
      Location:647 → 682
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 645
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61932463..62044956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250507.2 → XP_030106367.1  actin-binding LIM protein 3 isoform X7

      Conserved Domains (6) summary
      smart00153
      Location:536 → 571
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 534
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    2. XM_030250506.1 → XP_030106366.1  actin-binding LIM protein 3 isoform X4

      Conserved Domains (6) summary
      smart00153
      Location:598 → 633
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 596
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    3. XM_036161169.1 → XP_036017062.1  actin-binding LIM protein 3 isoform X2

      Conserved Domains (6) summary
      smart00153
      Location:631 → 666
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 630
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    4. XM_006526006.5 → XP_006526069.1  actin-binding LIM protein 3 isoform X2

      Conserved Domains (6) summary
      smart00153
      Location:631 → 666
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 630
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    5. XM_006526005.5 → XP_006526068.1  actin-binding LIM protein 3 isoform X1

      Conserved Domains (6) summary
      smart00153
      Location:637 → 672
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 635
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    6. XM_006526010.5 → XP_006526073.1  actin-binding LIM protein 3 isoform X6

      Conserved Domains (6) summary
      smart00153
      Location:552 → 587
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 550
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    7. XM_006526009.5 → XP_006526072.1  actin-binding LIM protein 3 isoform X5

      Conserved Domains (6) summary
      smart00153
      Location:585 → 620
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 583
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    8. XM_006526008.5 → XP_006526071.1  actin-binding LIM protein 3 isoform X4

      Conserved Domains (6) summary
      smart00153
      Location:598 → 633
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 596
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    9. XM_006526007.5 → XP_006526070.1  actin-binding LIM protein 3 isoform X3

      Conserved Domains (6) summary
      smart00153
      Location:614 → 649
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 612
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    10. XM_030250508.1 → XP_030106368.1  actin-binding LIM protein 3 isoform X8

      Conserved Domains (4) summary
      smart00153
      Location:511 → 546
      VHP; Villin headpiece domain
      cd09329
      Location:15 → 66
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:74 → 129
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:137 → 509
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    11. XM_006526012.2 → XP_006526075.1  actin-binding LIM protein 3 isoform X9

      Conserved Domains (3) summary
      smart00153
      Location:408 → 443
      VHP; Villin headpiece domain
      cl02475
      Location:12 → 26
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:34 → 406
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZX8.2 GenPept UniProtKB/Swiss-Prot:Q69ZX8

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