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    Zfp27 zinc finger protein 27 [ Mus musculus (house mouse) ]

    Gene ID: 22689, updated on 21-May-2024

    Summary

    Official Symbol
    Zfp27provided by MGI
    Official Full Name
    zinc finger protein 27provided by MGI
    Primary source
    MGI:MGI:99174
    See related
    Ensembl:ENSMUSG00000062040 AllianceGenome:MGI:99174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mkr-4; Zfp-27; mszf76
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including liver; pancreas; reproductive system; spleen; and urinary system. Orthologous to several human genes including ZNF585A (zinc finger protein 585A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 3.7), whole brain E14.5 (RPKM 3.3) and 28 other tissues See more
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    Genomic context

    See Zfp27 in Genome Data Viewer
    Location:
    7 B1; 7 17.26 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29592762..29605976, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29893331..29906569, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 940 Neighboring gene STARR-positive B cell enhancer ABC_E8836 Neighboring gene STARR-positive B cell enhancer ABC_E10434 Neighboring gene zinc finger protein 420 Neighboring gene STARR-seq mESC enhancer starr_18494 Neighboring gene STARR-positive B cell enhancer ABC_E9288 Neighboring gene microRNA 7668 Neighboring gene zinc finger protein 383 Neighboring gene STARR-seq mESC enhancer starr_18496 Neighboring gene zinc finger protein 74 Neighboring gene RIKEN cDNA C230062I16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30738577-30738760

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 27
    Names
    protein mKR4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037707.1NP_001032796.1  zinc finger protein 27 isoform 1

      See identical proteins and their annotated locations for NP_001032796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
      Source sequence(s)
      AC149283, BY740816, BY776985
      Consensus CDS
      CCDS21076.1
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Related
      ENSMUSP00000054012.9, ENSMUST00000053521.15
      Conserved Domains (5) summary
      COG5048
      Location:317746
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:152171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:237
      KRAB; KRAB box
      pfam13465
      Location:752775
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001285797.1NP_001272726.1  zinc finger protein 27 isoform 1

      See identical proteins and their annotated locations for NP_001272726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AI854840, AK135293
      Consensus CDS
      CCDS21076.1
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Related
      ENSMUSP00000123953.2, ENSMUST00000162592.8
      Conserved Domains (5) summary
      COG5048
      Location:317746
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:152171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:237
      KRAB; KRAB box
      pfam13465
      Location:752775
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001285798.1NP_001272727.1  zinc finger protein 27 isoform 1

      See identical proteins and their annotated locations for NP_001272727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
      Source sequence(s)
      AI854840, AK028500, AK135293
      Consensus CDS
      CCDS21076.1
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Conserved Domains (5) summary
      COG5048
      Location:317746
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:152171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:237
      KRAB; KRAB box
      pfam13465
      Location:752775
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001421813.1NP_001408742.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Related
      ENSMUSP00000125232.2, ENSMUST00000159920.2
    5. NM_001421814.1NP_001408743.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
    6. NM_001421815.1NP_001408744.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
    7. NM_001421816.1NP_001408745.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
    8. NM_001421817.1NP_001408746.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
    9. NM_001421818.1NP_001408747.1  zinc finger protein 27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149283
    10. NM_011754.2NP_035884.2  zinc finger protein 27 isoform 1

      See identical proteins and their annotated locations for NP_035884.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
      Source sequence(s)
      AC149283, BB611831, BY776985
      Consensus CDS
      CCDS21076.1
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Related
      ENSMUSP00000124684.2, ENSMUST00000161904.8
      Conserved Domains (5) summary
      COG5048
      Location:317746
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:152171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:237
      KRAB; KRAB box
      pfam13465
      Location:752775
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29592762..29605976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242389.2XP_030098249.1  zinc finger protein 27 isoform X2

      Conserved Domains (5) summary
      smart00349
      Location:256
      KRAB; krueppel associated box
      COG5048
      Location:241670
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:635655
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:7695
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:676699
      zf-H2C2_2; Zinc-finger double domain