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Conserved domains on  [gi|551410565|ref|NP_001272726|]
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zinc finger protein 27 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-38 1.09e-16

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.94  E-value: 1.09e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 551410565     2 DVTIDFSREEWQHLDPAQRSLYRDVVQETYSHLRSVE 38
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
317-746 3.52e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 3.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 317 YVCIECGQAFIQKTHLVAHRRIHTGEKPYAC--DGCGKAFLSKSQLLVHQRIHSRVRPCVSLDRAKP--FSSAPNLLPRK 392
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 393 KVqMREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGDCGKAF--TQKSALTVHRRIHTgeksyvcVKCGLAFVQRA 470
Cdd:COG5048  114 SS-NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPAN-------SLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 471 HLDAHQVIHTGEKPYQCGHCGKFFTSKSQLHVHKRIH--TGEKPYVCSNCGKA---FANRSNLITHQKTHTGEKAYVCAR 545
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKsllSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 546 CGKAFTQRSDLVTHQRIHTG-EKPYGCSTCGKAFTQKSHLSIHEKihtgerqygcrdcgkafnqksilivhQKIHTGE-- 622
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLR--------------------------SVNHSGEsl 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 623 KPHVCAE--CGRAFIRKSNFITHQRIHTGEKPYGC--TDCGKSFTSKS-----QLLVHRPIHTGEKPYVCA--ECGKAFS 691
Cdd:COG5048  320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFK 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 551410565 692 GRSNLSKHQKTHTGEKPYAC--SECGKSFRQKSELITHHRIHTGEKPYDCGDCGKSF 746
Cdd:COG5048  400 RDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-372 1.26e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 212 KACSQTSEFLTHQKTHTR-EKPYKCGDCGKSFFQVSSLFRHRR--IHTGEKL--YDCSH--CGKGFSYNSDLRIHQKIHT 284
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 285 GEKRHGCV--DCGKAFTQKST-----LRMHQKIHTGERAYVCI--ECGQAFIQKTHLVAHRRIHTGEKPYACD--GCGKA 353
Cdd:COG5048  348 SISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKS 427

                        170
                 ....*....|....*....
gi 551410565 354 FLSKSQLLVHQRIHSRVRP 372
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
752-775 7.52e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.52e-04
                          10        20
                  ....*....|....*....|....
gi 551410565  752 LQVHQRIHTGEKPYRCAECGKAFT 775
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-38 1.09e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.94  E-value: 1.09e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 551410565     2 DVTIDFSREEWQHLDPAQRSLYRDVVQETYSHLRSVE 38
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-37 1.49e-16

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 73.66  E-value: 1.49e-16
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 551410565    2 DVTIDFSREEWQHLDPAQRSLYRDVVQETYSHLRSV 37
Cdd:pfam01352   6 DVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-36 3.61e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 3.61e-15
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 551410565   2 DVTIDFSREEWQHLDPAQRSLYRDVVQETYSHLRS 36
Cdd:cd07765    5 DVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
317-746 3.52e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 3.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 317 YVCIECGQAFIQKTHLVAHRRIHTGEKPYAC--DGCGKAFLSKSQLLVHQRIHSRVRPCVSLDRAKP--FSSAPNLLPRK 392
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 393 KVqMREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGDCGKAF--TQKSALTVHRRIHTgeksyvcVKCGLAFVQRA 470
Cdd:COG5048  114 SS-NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPAN-------SLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 471 HLDAHQVIHTGEKPYQCGHCGKFFTSKSQLHVHKRIH--TGEKPYVCSNCGKA---FANRSNLITHQKTHTGEKAYVCAR 545
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKsllSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 546 CGKAFTQRSDLVTHQRIHTG-EKPYGCSTCGKAFTQKSHLSIHEKihtgerqygcrdcgkafnqksilivhQKIHTGE-- 622
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLR--------------------------SVNHSGEsl 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 623 KPHVCAE--CGRAFIRKSNFITHQRIHTGEKPYGC--TDCGKSFTSKS-----QLLVHRPIHTGEKPYVCA--ECGKAFS 691
Cdd:COG5048  320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFK 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 551410565 692 GRSNLSKHQKTHTGEKPYAC--SECGKSFRQKSELITHHRIHTGEKPYDCGDCGKSF 746
Cdd:COG5048  400 RDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-372 1.26e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 212 KACSQTSEFLTHQKTHTR-EKPYKCGDCGKSFFQVSSLFRHRR--IHTGEKL--YDCSH--CGKGFSYNSDLRIHQKIHT 284
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 285 GEKRHGCV--DCGKAFTQKST-----LRMHQKIHTGERAYVCI--ECGQAFIQKTHLVAHRRIHTGEKPYACD--GCGKA 353
Cdd:COG5048  348 SISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKS 427

                        170
                 ....*....|....*....
gi 551410565 354 FLSKSQLLVHQRIHSRVRP 372
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
695-720 4.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 551410565  695 NLSKHQKTHTGEKPYACSECGKSFRQ 720
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
752-775 7.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.52e-04
                          10        20
                  ....*....|....*....|....
gi 551410565  752 LQVHQRIHTGEKPYRCAECGKAFT 775
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-38 1.09e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.94  E-value: 1.09e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 551410565     2 DVTIDFSREEWQHLDPAQRSLYRDVVQETYSHLRSVE 38
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-37 1.49e-16

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 73.66  E-value: 1.49e-16
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 551410565    2 DVTIDFSREEWQHLDPAQRSLYRDVVQETYSHLRSV 37
Cdd:pfam01352   6 DVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-36 3.61e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 3.61e-15
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 551410565   2 DVTIDFSREEWQHLDPAQRSLYRDVVQETYSHLRS 36
Cdd:cd07765    5 DVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
317-746 3.52e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 3.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 317 YVCIECGQAFIQKTHLVAHRRIHTGEKPYAC--DGCGKAFLSKSQLLVHQRIHSRVRPCVSLDRAKP--FSSAPNLLPRK 392
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 393 KVqMREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGDCGKAF--TQKSALTVHRRIHTgeksyvcVKCGLAFVQRA 470
Cdd:COG5048  114 SS-NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPAN-------SLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 471 HLDAHQVIHTGEKPYQCGHCGKFFTSKSQLHVHKRIH--TGEKPYVCSNCGKA---FANRSNLITHQKTHTGEKAYVCAR 545
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKsllSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 546 CGKAFTQRSDLVTHQRIHTG-EKPYGCSTCGKAFTQKSHLSIHEKihtgerqygcrdcgkafnqksilivhQKIHTGE-- 622
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLR--------------------------SVNHSGEsl 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 623 KPHVCAE--CGRAFIRKSNFITHQRIHTGEKPYGC--TDCGKSFTSKS-----QLLVHRPIHTGEKPYVCA--ECGKAFS 691
Cdd:COG5048  320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFK 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 551410565 692 GRSNLSKHQKTHTGEKPYAC--SECGKSFRQKSELITHHRIHTGEKPYDCGDCGKSF 746
Cdd:COG5048  400 RDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-817 7.24e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 7.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 383 SSAPNLLPRKKVQMREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGD--CGKAFTQKSALTVHRRIHTGEKSYVCV 460
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 461 K-CGLAFVQRAHLDAHQVIHTGEKPYQCGHCGKFFTSKSQLHVHKRIHTGEKPYVCSNCGKAFANR--SNLITHQKTHtg 537
Cdd:COG5048   96 KsLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPA-- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 538 ekayvcARCGKAFTQRSDLVTHQRIHTGEKPYGCSTCGKAFTQKSHLSIHekiHTGERQYGCRDCGKAFNQKSILIVHQk 617
Cdd:COG5048  174 ------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSD---QNLENSSSSLPLTTNSQLSPKSLLSQ- 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 618 ihtgekphvcaecgrafiRKSNFITHQRIHTGEKPYGCTDCGKSFTSKSQLLVHRPIHTG-EKPYVCAECGKAFSGRSNL 696
Cdd:COG5048  244 ------------------SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 697 SKHQKT--HTGE--KPYACSE--CGKSFRQKSELITHHRIHTGEKPYDC--GDCGKSFTKKS-----QLQVHQRIHTGEK 763
Cdd:COG5048  306 TRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDK 385

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 551410565 764 PYRCA--ECGKAFTDRSNLNKHQTTHTGEKP--YKCVVCGKGFVQKSVLSIHENVHTS 817
Cdd:COG5048  386 KSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-699 1.30e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 231 KPYKCGDCGKSFFQVSSLFRHRRIHTGEKLYDCSH--CGKGFSYNSDLRIHQKIHTGEKRHgcVDCGKAFTQKSTLRMHQ 308
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 309 KIHTgerayvciecgqafiqkthlvahrrIHTGEKPYACDGCGKAFLSKSQLLVHQRIHSRVRPCvsLDRAKPFSSAPNL 388
Cdd:COG5048  110 LSSS-------------------------SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNN--PLPGNNSSSVNTP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 389 LPRKKvqmREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGDCGKAFTQKSALTVHRRIHtgeksyvcvkcglafvQ 468
Cdd:COG5048  163 QSNSL---HPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN----------------S 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 469 RAHLDAHQVIHTGEKPYQcgHCGKFFTSKSQLHVHKRIHtgekpYVCSNCGKAFANRSNLITHQKTHTG-EKAYVCARCG 547
Cdd:COG5048  224 SSSLPLTTNSQLSPKSLL--SQSPSSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCN 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 548 KAFTQRSDLVTHQR--IHTGE--KPYGC--STCGKAFTQKSHLSIHEKIHTGERQYGC--RDCGKAFNQKSI-----LIV 614
Cdd:COG5048  297 ISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQ 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 615 HQKIHTGEKPHVCA--ECGRAFIRKSNFITHQRIHTGEKPYGCTD--CGKSFTSKSQLLVHRPIHTgEKPYVCAECGKAF 690
Cdd:COG5048  377 QYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSF 455


                 ....*....
gi 551410565 691 SGRSNLSKH 699
Cdd:COG5048  456 RRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-372 1.26e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 212 KACSQTSEFLTHQKTHTR-EKPYKCGDCGKSFFQVSSLFRHRR--IHTGEKL--YDCSH--CGKGFSYNSDLRIHQKIHT 284
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 285 GEKRHGCV--DCGKAFTQKST-----LRMHQKIHTGERAYVCI--ECGQAFIQKTHLVAHRRIHTGEKPYACD--GCGKA 353
Cdd:COG5048  348 SISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKS 427

                        170
                 ....*....|....*....
gi 551410565 354 FLSKSQLLVHQRIHSRVRP 372
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAP 446
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 697-788 3.67e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 697 SKHQKThTGEKPYACS--ECGKSFRQKSELiTHHRIHtgekpydcGDCGKSFTKKSQLQVHQRIHTGEKPYRCAECGKAF 774
Cdd:COG5189  339 SRMLKV-KDGKPYKCPveGCNKKYKNQNGL-KYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY 408

                         90
                 ....*....|....
gi 551410565 775 TDRSNLNKHQTTHT 788
Cdd:COG5189  409 KNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
695-720 4.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 551410565  695 NLSKHQKTHTGEKPYACSECGKSFRQ 720
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
752-775 7.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.52e-04
                          10        20
                  ....*....|....*....|....
gi 551410565  752 LQVHQRIHTGEKPYRCAECGKAFT 775
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 509-589 1.54e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551410565 509 GEKPYVCS--NCGKAFANRSNLITHQKThtgekayvcARCGKAFTQRSDLVTHQRIHTGEKPYGCSTCGKAFTQKSHLSI 586
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 551410565 587 HEK 589
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 4.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 551410565  415 ELIIHQRTHTGEKPYQCGDCGKAFTQ 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-524 5.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.69e-03
                          10        20
                  ....*....|....*....|..
gi 551410565  503 HKRIHTGEKPYVCSNCGKAFAN 524
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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