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    Adam6a a disintegrin and metallopeptidase domain 6A [ Mus musculus (house mouse) ]

    Gene ID: 238406, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Adam6aprovided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 6Aprovided by MGI
    Primary source
    MGI:MGI:2676316
    See related
    Ensembl:ENSMUSG00000043945 AllianceGenome:MGI:2676316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adam6; tMDCIV
    Summary
    Predicted to be involved in male gonad development. Located in external side of plasma membrane and sperm head plasma membrane. Part of protein-containing complex. Orthologous to human ADAM6 (ADAM metallopeptidase domain 6 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    12 F1; 12 62.12 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113507528..113510034)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113543908..113546414)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33384 Neighboring gene immunoglobulin heavy chain complex Neighboring gene immunoglobulin heavy diversity 3-1 Neighboring gene immunoglobulin heavy diversity 5-1 Neighboring gene immunoglobulin heavy variable V5-1 Neighboring gene immunoglobulin heavy variable 2-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. Marcello MR, et al. J Biol Chem, 2011 Apr 15. PMID 21339297, Free PMC Article
    2. Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Choi I, et al. Genomics, 2004 Apr. PMID 15028286
    3. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Han C, et al. Biol Reprod, 2009 May. PMID 19129510
    4. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations. Grayson P, et al. BMC Evol Biol, 2013 Sep 30. PMID 24079728, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.
      Title: Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.
    2. The levels of ADAM4 and ADAM6 are dramatically reduced in Adam2 and Adam3 knockout sperm defective in various fertilization processes.
      Title: Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm head plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    a disintegrin and metalloprotease domain 6
    Names
    a disintegrin and metallopeptidase domain 6
    disintegrin and metalloproteinase domain 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005838.1 

      Range
      296312..298818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_174885.3 → NP_777479.2  a disintegrin and metalloprotease domain 6

      See identical proteins and their annotated locations for NP_777479.2

      Status: VALIDATED

      Source sequence(s)
      AC073553
      Consensus CDS
      CCDS26208.1
      UniProtKB/TrEMBL
      B2RSY5, Q8CGQ1
      Related
      ENSMUSP00000059315.2, ENSMUST00000053086.3
      Conserved Domains (4) summary
      smart00608
      Location:503 → 638
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:217 → 406
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:427 → 500
      Disintegrin; Disintegrin
      pfam01562
      Location:69 → 166
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      113507528..113510034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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