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    Luc7l3 LUC7-like 3 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 67684, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Luc7l3provided by MGI
    Official Full Name
    LUC7-like 3 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1914934
    See related
    Ensembl:ENSMUSG00000020863 AllianceGenome:MGI:1914934
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Luc7a; 3300001P08Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site selection. Predicted to act upstream of or within mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of U1 snRNP and U2-type prespliceosome. Is expressed in central nervous system and retina. Orthologous to human LUC7L3 (LUC7 like 3 pre-mRNA splicing factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 59.6), CNS E11.5 (RPKM 55.5) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 58.9 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94181899..94213196, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94291073..94322329, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30463 Neighboring gene STARR-positive B cell enhancer ABC_E11487 Neighboring gene predicted gene, 38956 Neighboring gene ANKRD40 C-terminal like Neighboring gene STARR-positive B cell enhancer ABC_E5270 Neighboring gene STARR-positive B cell enhancer ABC_E7046 Neighboring gene ankyrin repeat domain 40 Neighboring gene ATP-binding cassette, sub-family C member 3 Neighboring gene predicted gene, 51871

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Charles CH, et al. Oncogene, 1992 Jan. PMID 1741163
    2. Comprehensive interactome of Otx2 in the adult mouse neural retina. Fant B, et al. Genesis, 2015 Nov. PMID 26426291
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    luc7-like protein 3
    Names
    cisplatin resistance-associated overexpressed protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361573.1 → NP_001348502.1  luc7-like protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK019464, AK043494, AK151228
      Consensus CDS
      CCDS88224.1
      Related
      ENSMUSP00000129919.2, ENSMUST00000166312.8
      Conserved Domains (1) summary
      pfam03194
      Location:4 → 233
      LUC7; LUC7 N_terminus

    2. NM_001361574.1 → NP_001348503.1  luc7-like protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645846, AL645965
      Consensus CDS
      CCDS88223.1
      UniProtKB/Swiss-Prot
      Q3U9D5, Q5SUF2, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4
      Related
      ENSMUSP00000103450.2, ENSMUST00000107820.2
      Conserved Domains (1) summary
      pfam03194
      Location:4 → 233
      LUC7; LUC7 N_terminus

    3. NM_001361575.1 → NP_001348504.1  luc7-like protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645846, AL645965
      Consensus CDS
      CCDS88223.1
      UniProtKB/Swiss-Prot
      Q3U9D5, Q5SUF2, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4
      Related
      ENSMUSP00000103451.3, ENSMUST00000107821.9
      Conserved Domains (1) summary
      pfam03194
      Location:4 → 233
      LUC7; LUC7 N_terminus

    4. NM_026313.2 → NP_080589.1  luc7-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_080589.1

      Status: VALIDATED

      Source sequence(s)
      AL645846, AL645965
      Consensus CDS
      CCDS25252.1
      UniProtKB/Swiss-Prot
      Q5SUF2
      Related
      ENSMUSP00000021226.8, ENSMUST00000021226.14
      Conserved Domains (1) summary
      pfam03194
      Location:4 → 233
      LUC7; LUC7 N_terminus

    RNA

    1. NR_155068.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645846, AL645965

    2. NR_155069.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645846, AL645965

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94181899..94213196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156917.1 → XP_036012810.1  luc7-like protein 3 isoform X3

      Conserved Domains (1) summary
      cl27291
      Location:1 → 58
      LUC7; LUC7 N_terminus

    2. XM_036156915.1 → XP_036012808.1  luc7-like protein 3 isoform X1

      Conserved Domains (1) summary
      pfam03194
      Location:4 → 170
      LUC7; LUC7 N_terminus

    3. XM_036156916.1 → XP_036012809.1  luc7-like protein 3 isoform X2

      Conserved Domains (1) summary
      cl27291
      Location:4 → 170
      LUC7; LUC7 N_terminus

    RNA

    1. XR_001780043.3 RNA Sequence

    2. XR_001780044.3 RNA Sequence

    3. XR_388511.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SUF2.1 GenPept UniProtKB/Swiss-Prot:Q5SUF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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