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    Rbm25 RNA binding motif protein 25 [ Mus musculus (house mouse) ]

    Gene ID: 67039, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rbm25provided by MGI
    Official Full Name
    RNA binding motif protein 25provided by MGI
    Primary source
    MGI:MGI:1914289
    See related
    Ensembl:ENSMUSG00000010608 AllianceGenome:MGI:1914289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNPC7; 2600011C06Rik; 2610015J01Rik; A130095G20Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Predicted to act upstream of or within RNA splicing; apoptotic process; and mRNA processing. Predicted to be located in nuclear speck. Is expressed in central nervous system and sensory organ. Orthologous to human RBM25 (RNA binding motif protein 25). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 31.0), CNS E14 (RPKM 19.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 38.81 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (83678990..83729901)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83632208..83683127)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9860 Neighboring gene STARR-seq mESC enhancer starr_32707 Neighboring gene STARR-seq mESC enhancer starr_32708 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene zinc finger, FYVE domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32712 Neighboring gene STARR-positive B cell enhancer ABC_E1444 Neighboring gene STARR-seq mESC enhancer starr_32714 Neighboring gene STARR-seq mESC enhancer starr_32715 Neighboring gene H2A histone family, member Z pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7159 Neighboring gene presenilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E3061 Neighboring gene farnesyl diphosphate synthetase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice. Bramlett C, et al. Blood, 2023 Jun 15. PMID 36947858,
    2. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia. Ge Y, et al. Nat Commun, 2019 Jan 11. PMID 30635567, Free PMC Article
    3. Analysis of phosphorylation-dependent protein-protein interactions of histone h3. Klingberg R, et al. ACS Chem Biol, 2015 Jan 16. PMID 25330109
    4. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice.
      Title: RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice.
    2. tumor suppressive function in acute myeloid leukemia
      Title: The splicing factor RBM25 controls MYC activity in acute myeloid leukemia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364415.1 → NP_001351344.1  RNA-binding protein 25 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC055772
      Conserved Domains (2) summary
      smart00311
      Location:777 → 850
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    2. NM_001364416.1 → NP_001351345.1  RNA-binding protein 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC055772
      Consensus CDS
      CCDS49107.1
      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758 → 831
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    3. NM_027349.4 → NP_081625.3  RNA-binding protein 25 isoform 2

      See identical proteins and their annotated locations for NP_081625.3

      Status: VALIDATED

      Source sequence(s)
      AC055772, AK011403, AK142132, BY169048, CJ063347
      Consensus CDS
      CCDS49107.1
      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Related
      ENSMUSP00000048470.9, ENSMUST00000048155.16
      Conserved Domains (2) summary
      smart00311
      Location:758 → 831
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      83678990..83729901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157593.1 → XP_036013486.1  RNA-binding protein 25 isoform X4

      Conserved Domains (2) summary
      smart00311
      Location:740 → 813
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    2. XM_006516166.4 → XP_006516229.1  RNA-binding protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006516229.1

      Conserved Domains (2) summary
      smart00311
      Location:777 → 850
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    3. XM_036157590.1 → XP_036013483.1  RNA-binding protein 25 isoform X2

      Conserved Domains (2) summary
      smart00311
      Location:759 → 832
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    4. XM_006516168.5 → XP_006516231.1  RNA-binding protein 25 isoform X3

      See identical proteins and their annotated locations for XP_006516231.1

      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758 → 831
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    5. XM_006516164.5 → XP_006516227.1  RNA-binding protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006516227.1

      Conserved Domains (2) summary
      smart00311
      Location:777 → 850
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    6. XM_036157594.1 → XP_036013487.1  RNA-binding protein 25 isoform X4

      Conserved Domains (2) summary
      smart00311
      Location:740 → 813
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    7. XM_036157595.1 → XP_036013488.1  RNA-binding protein 25 isoform X4

      Conserved Domains (2) summary
      smart00311
      Location:740 → 813
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    8. XM_030246879.2 → XP_030102739.1  RNA-binding protein 25 isoform X5

      Conserved Domains (1) summary
      smart00311
      Location:554 → 627
      PWI; domain in splicing factors

    9. XM_036157591.1 → XP_036013484.1  RNA-binding protein 25 isoform X3

      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758 → 831
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    10. XM_036157596.1 → XP_036013489.1  RNA-binding protein 25 isoform X5

      Conserved Domains (1) summary
      smart00311
      Location:554 → 627
      PWI; domain in splicing factors

    11. XM_006516165.5 → XP_006516228.1  RNA-binding protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006516228.1

      Conserved Domains (2) summary
      smart00311
      Location:777 → 850
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    12. XM_036157589.1 → XP_036013482.1  RNA-binding protein 25 isoform X2

      Conserved Domains (2) summary
      smart00311
      Location:759 → 832
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    13. XM_036157588.1 → XP_036013481.1  RNA-binding protein 25 isoform X1

      Conserved Domains (2) summary
      smart00311
      Location:777 → 850
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    14. XM_036157592.1 → XP_036013485.1  RNA-binding protein 25 isoform X3

      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758 → 831
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    15. XM_030246881.2 → XP_030102741.1  RNA-binding protein 25 isoform X5

      Conserved Domains (1) summary
      smart00311
      Location:554 → 627
      PWI; domain in splicing factors

    16. XM_006516169.5 → XP_006516232.1  RNA-binding protein 25 isoform X5

      See identical proteins and their annotated locations for XP_006516232.1

      UniProtKB/Swiss-Prot
      B2RY56
      Conserved Domains (1) summary
      smart00311
      Location:554 → 627
      PWI; domain in splicing factors

    17. XM_036157587.1 → XP_036013480.1  RNA-binding protein 25 isoform X1

      Conserved Domains (2) summary
      smart00311
      Location:777 → 850
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    18. XM_030246878.2 → XP_030102738.1  RNA-binding protein 25 isoform X3

      UniProtKB/Swiss-Prot
      B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
      Conserved Domains (2) summary
      smart00311
      Location:758 → 831
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RY56.2 GenPept UniProtKB/Swiss-Prot:B2RY56

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