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    Ccdc90b coiled-coil domain containing 90B [ Mus musculus (house mouse) ]

    Gene ID: 66365, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ccdc90bprovided by MGI
    Official Full Name
    coiled-coil domain containing 90Bprovided by MGI
    Primary source
    MGI:MGI:1913615
    See related
    Ensembl:ENSMUSG00000030613 AllianceGenome:MGI:1913615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310015N07Rik
    Summary
    Located in mitochondrion. Orthologous to human CCDC90B (coiled-coil domain containing 90B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 12.7), CNS E14 (RPKM 12.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E1; 7 51.51 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (92210350..92231502)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (92561149..92582294)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene discs large MAGUK scaffold protein 2 Neighboring gene predicted gene, 53382 Neighboring gene STARR-seq mESC enhancer starr_19525 Neighboring gene predicted gene, 31491 Neighboring gene STARR-positive B cell enhancer ABC_E6571 Neighboring gene STARR-positive B cell enhancer ABC_E291 Neighboring gene STARR-seq mESC enhancer starr_19528 Neighboring gene ankyrin repeat domain 42 Neighboring gene predicted gene, 26944 Neighboring gene pantothenate kinase 1 pseudogene Neighboring gene PCF11 cleavage and polyadenylation factor subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144297

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 90B, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162918.1 → NP_001156390.1  coiled-coil domain-containing protein 90B, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001156390.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      BB617939, BC034878
      Consensus CDS
      CCDS52309.1
      UniProtKB/Swiss-Prot
      Q8C3X2
      Related
      ENSMUSP00000082090.5, ENSMUST00000085017.5
      Conserved Domains (1) summary
      pfam07798
      Location:61 → 218
      DUF1640; Protein of unknown function (DUF1640)

    2. NM_025515.3 → NP_079791.2  coiled-coil domain-containing protein 90B, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_079791.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI643175, AK084673, BB617939, BC034878
      Consensus CDS
      CCDS21449.1
      UniProtKB/Swiss-Prot
      Q8C3X2, Q8JZY3, Q9D7C1
      Related
      ENSMUSP00000032842.7, ENSMUST00000032842.13
      Conserved Domains (1) summary
      pfam07798
      Location:61 → 252
      DUF1640; Protein of unknown function (DUF1640)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      92210350..92231502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153349.1 → XP_036009242.1  coiled-coil domain-containing protein 90B, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam07798
      Location:1 → 151
      DUF1640; Protein of unknown function (DUF1640)

    2. XM_036153350.1 → XP_036009243.1  coiled-coil domain-containing protein 90B, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam07798
      Location:1 → 151
      DUF1640; Protein of unknown function (DUF1640)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C3X2.1 GenPept UniProtKB/Swiss-Prot:Q8C3X2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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