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Conserved domains on  [gi|251823843|ref|NP_079791|]
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coiled-coil domain-containing protein 90B, mitochondrial isoform 1 [Mus musculus]

Protein Classification

CCDC90 family protein( domain architecture ID 10544633)

coiled-coil domain-containing protein 90 (CCDC90) family protein similar to Homo sapiens mitochondrial calcium uniporter regulator 1 (MCUR1/CCDC90A) that is a key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 61-253 4.56e-70

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


:

Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 213.14  E-value: 4.56e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823843   61 FDTHALVQDLETHGFDKTQAQTIVSVLSTLSNVSLDTIYKEMVTKAQQEITVQQLMAHLDSIRKDMVILEKSEFANLRAE 140
Cdd:pfam07798   1 FDTHAFVRQLEEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKEDLENETYLQKADLAELRSELQILEKSEFAALRSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823843  141 NEKMKIELDQVKQQLTNETSRIRADNKLDINLERSRVTDMFTDQEKQlieatnefakkdtqtksiISETSNKIDTEIASL 220
Cdd:pfam07798  81 NEKLRRELEKLKQRLREEITKLKADVRLDLNLEKGRIREELKAQELK------------------IQETNNKIDTEIANL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 251823843  221 KTLMESSKLETIRYLAASVFTCLAIALGFYRFW 253
Cdd:pfam07798 143 RTQIESVKWDVIRYLIGVITGCLALVLAYLRLL 175
 
Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 61-253 4.56e-70

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 213.14  E-value: 4.56e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823843   61 FDTHALVQDLETHGFDKTQAQTIVSVLSTLSNVSLDTIYKEMVTKAQQEITVQQLMAHLDSIRKDMVILEKSEFANLRAE 140
Cdd:pfam07798   1 FDTHAFVRQLEEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKEDLENETYLQKADLAELRSELQILEKSEFAALRSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823843  141 NEKMKIELDQVKQQLTNETSRIRADNKLDINLERSRVTDMFTDQEKQlieatnefakkdtqtksiISETSNKIDTEIASL 220
Cdd:pfam07798  81 NEKLRRELEKLKQRLREEITKLKADVRLDLNLEKGRIREELKAQELK------------------IQETNNKIDTEIANL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 251823843  221 KTLMESSKLETIRYLAASVFTCLAIALGFYRFW 253
Cdd:pfam07798 143 RTQIESVKWDVIRYLIGVITGCLALVLAYLRLL 175
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 82-228 1.76e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 39.65  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823843    82 TIVSVLSTLSNVSLDTIYKEMVTKAQQ-EITVQQLMAHLDSIrKDMVILEKSEFANLRAENEKMKIE-LDQVKQQLTNET 159
Cdd:TIGR01612  660 TIKSELSKIYEDDIDALYNELSSIVKEnAIDNTEDKAKLDDL-KSKIDKEYDKIQNMETATVELHLSnIENKKNELLDII 738

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 251823843   160 SRIRADNKLDINLERSRVTDMFTDQEKQLIEATNEFAKKDTQT---KSIISETSNKIDTEIASLKTLMESSK 228
Cdd:TIGR01612  739 VEIKKHIHGEINKDLNKILEDFKNKEKELSNKINDYAKEKDELnkyKSKISEIKNHYNDQINIDNIKDEDAK 810
 
Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 61-253 4.56e-70

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 213.14  E-value: 4.56e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823843   61 FDTHALVQDLETHGFDKTQAQTIVSVLSTLSNVSLDTIYKEMVTKAQQEITVQQLMAHLDSIRKDMVILEKSEFANLRAE 140
Cdd:pfam07798   1 FDTHAFVRQLEEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKEDLENETYLQKADLAELRSELQILEKSEFAALRSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823843  141 NEKMKIELDQVKQQLTNETSRIRADNKLDINLERSRVTDMFTDQEKQlieatnefakkdtqtksiISETSNKIDTEIASL 220
Cdd:pfam07798  81 NEKLRRELEKLKQRLREEITKLKADVRLDLNLEKGRIREELKAQELK------------------IQETNNKIDTEIANL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 251823843  221 KTLMESSKLETIRYLAASVFTCLAIALGFYRFW 253
Cdd:pfam07798 143 RTQIESVKWDVIRYLIGVITGCLALVLAYLRLL 175
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 82-228 1.76e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 39.65  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823843    82 TIVSVLSTLSNVSLDTIYKEMVTKAQQ-EITVQQLMAHLDSIrKDMVILEKSEFANLRAENEKMKIE-LDQVKQQLTNET 159
Cdd:TIGR01612  660 TIKSELSKIYEDDIDALYNELSSIVKEnAIDNTEDKAKLDDL-KSKIDKEYDKIQNMETATVELHLSnIENKKNELLDII 738

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 251823843   160 SRIRADNKLDINLERSRVTDMFTDQEKQLIEATNEFAKKDTQT---KSIISETSNKIDTEIASLKTLMESSK 228
Cdd:TIGR01612  739 VEIKKHIHGEINKDLNKILEDFKNKEKELSNKINDYAKEKDELnkyKSKISEIKNHYNDQINIDNIKDEDAK 810
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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