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    Krtdap keratinocyte differentiation associated protein [ Mus musculus (house mouse) ]

    Gene ID: 64661, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Krtdapprovided by MGI
    Official Full Name
    keratinocyte differentiation associated proteinprovided by MGI
    Primary source
    MGI:MGI:1928282
    See related
    Ensembl:ENSMUSG00000074199 AllianceGenome:MGI:1928282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kdap; sk221
    Summary
    Predicted to be involved in epidermis development. Predicted to act upstream of or within cell differentiation. Predicted to be located in lamellar body. Predicted to be active in extracellular space. Is expressed in nose and skin. Orthologous to human KRTDAP (keratinocyte differentiation associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 128.1), limb E14.5 (RPKM 47.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B1; 7 19.24 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30487330..30490514)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30787905..30791089)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene suprabasin Neighboring gene dermokine Neighboring gene STARR-seq mESC enhancer starr_18532 Neighboring gene STARR-seq mESC enhancer starr_18534 Neighboring gene predicted gene, 32236 Neighboring gene free fatty acid receptor 2 Neighboring gene STARR-seq mESC enhancer starr_18536 Neighboring gene STARR-positive B cell enhancer ABC_E8162 Neighboring gene free fatty acid receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kdap, a novel gene associated with the stratification of the epithelium. Oomizu S, et al. Gene, 2000 Oct 3. PMID 11054531
    2. Identification of a conserved cluster of skin-specific genes encoding secreted proteins. Moffatt P, et al. Gene, 2004 Jun 9. PMID 15256262
    3. Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression. Bazzi H, et al. Dev Dyn, 2007 Apr. PMID 17330888
    4. Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ. Saito K, et al. iScience, 2020 Jul 24. PMID 32674056, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drmkn and Krtdap are the highest differentially expressed genes in epidermis embryonic development in mice.
      Title: Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epidermis development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellar body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratinocyte differentiation-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033131.4 → NP_001028303.1  keratinocyte differentiation-associated protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_001028303.1

      Status: VALIDATED

      Source sequence(s)
      AC165340
      Consensus CDS
      CCDS21110.1
      UniProtKB/Swiss-Prot
      B7ZNU7, Q3V2T1, Q3V2T4
      Related
      ENSMUSP00000096159.2, ENSMUST00000098559.3
      Conserved Domains (1) summary
      pfam15200
      Location:24 → 102
      KRTDAP; Keratinocyte differentiation-associated

    2. NM_001364009.1 → NP_001350938.1  keratinocyte differentiation-associated protein isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC165340
      Consensus CDS
      CCDS90206.1
      UniProtKB/TrEMBL
      B7ZNU6
      Related
      ENSMUSP00000139443.2, ENSMUST00000189673.7
      Conserved Domains (1) summary
      pfam15200
      Location:24 → 76
      KRTDAP; Keratinocyte differentiation-associated

    3. NM_001364010.1 → NP_001350939.1  keratinocyte differentiation-associated protein isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      BC145437, BY703727, EH109090
      Consensus CDS
      CCDS90204.1
      Related
      ENSMUSP00000139461.2, ENSMUST00000190990.7
      Conserved Domains (1) summary
      pfam15200
      Location:24 → 90
      KRTDAP; Keratinocyte differentiation-associated

    4. NM_001364011.1 → NP_001350940.1  keratinocyte differentiation-associated protein isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      EH106855, EH109090
      Consensus CDS
      CCDS90205.1
      UniProtKB/TrEMBL
      A0A087WRR2
      Related
      ENSMUSP00000140737.2, ENSMUST00000187493.7
      Conserved Domains (1) summary
      pfam15200
      Location:24 → 88
      KRTDAP; Keratinocyte differentiation-associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30487330..30490514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V2T4.1 GenPept UniProtKB/Swiss-Prot:Q3V2T4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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