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    Myg1 melanocyte proliferating gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 60315, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Myg1provided by MGI
    Official Full Name
    melanocyte proliferating gene 1provided by MGI
    Primary source
    MGI:MGI:1929864
    See related
    Ensembl:ENSMUSG00000001285 AllianceGenome:MGI:1929864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gamm1; 0610023A07Rik; 2810433J21Rik; 5830429P19Rik
    Summary
    Predicted to enable nuclease activity. Acts upstream of or within locomotory exploration behavior. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; eye; hemolymphoid system gland; and male reproductive gland or organ. Orthologous to human MYG1 (MYG1 exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 22.9), adrenal adult (RPKM 22.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 F3; 15 57.49 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102240144..102246574)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102331709..102338139)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5520 Neighboring gene extra spindle pole bodies 1, separase Neighboring gene STARR-positive B cell enhancer ABC_E7421 Neighboring gene STARR-positive B cell enhancer ABC_E7422 Neighboring gene prefoldin 5 Neighboring gene microRNA 12187 Neighboring gene achalasia, adrenocortical insufficiency, alacrimia Neighboring gene STARR-seq mESC enhancer starr_39832 Neighboring gene predicted gene, 36246

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences. Philips MA, et al. Behav Brain Res, 2010 Feb 11. PMID 19818808
    2. Myg1 exonuclease couples the nuclear and mitochondrial translational programs through RNA processing. Grover R, et al. Nucleic Acids Res, 2019 Jun 20. PMID 31081026, Free PMC Article
    3. Characterization of MYG1 gene and protein: subcellular distribution and function. Philips MA, et al. Biol Cell, 2009 Jun. PMID 19014353
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the widely conserved dually localized protein Myg1 shows that it has a role as a 3'-5' RNA exonuclease
      Title: Myg1 exonuclease couples the nuclear and mitochondrial translational programs through RNA processing.
    2. Myg1 knockout decreases several behavioural differences (anxiety- and stress-related responses) between male and female animals, indicating that Myg1 contributes to the expression of sex-dependent behavioural differences in mice.
      Title: Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MYG1 exonuclease
    Names
    UPF0160 protein MYG1, mitochondrial
    protein Gamm1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021713.2 → NP_068359.1  MYG1 exonuclease precursor

      See identical proteins and their annotated locations for NP_068359.1

      Status: VALIDATED

      Source sequence(s)
      AF289484, BU851558, CJ180315
      Consensus CDS
      CCDS27879.1
      UniProtKB/Swiss-Prot
      Q9CYX0, Q9JK81
      UniProtKB/TrEMBL
      Q8R038
      Related
      ENSMUSP00000109312.3, ENSMUST00000113682.9
      Conserved Domains (1) summary
      pfam03690
      Location:45 → 365
      UPF0160; uncharacterized protein family (UPF0160)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      102240144..102246574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248679.1 → XP_030104539.1  MYG1 exonuclease isoform X1

      Conserved Domains (1) summary
      pfam03690
      Location:10 → 251
      UPF0160; Uncharacterized protein family (UPF0160)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JK81.1 GenPept UniProtKB/Swiss-Prot:Q9JK81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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