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    Zfp318 zinc finger protein 318 [ Mus musculus (house mouse) ]

    Gene ID: 57908, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zfp318provided by MGI
    Official Full Name
    zinc finger protein 318provided by MGI
    Primary source
    MGI:MGI:1889348
    See related
    Ensembl:ENSMUSG00000015597 AllianceGenome:MGI:1889348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TZF; Znf318; 2610034E08Rik; D530032D06Rik
    Summary
    Enables protein heterodimerization activity and protein homodimerization activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF318 (zinc finger protein 318). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.1), CNS E18 (RPKM 3.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 22.9 cM; 17 C
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46694444..46731846)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46383515..46420920)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene ATP-binding cassette, sub-family C member 10 Neighboring gene STARR-positive B cell enhancer ABC_E1943 Neighboring gene cDNA sequence BC040756 Neighboring gene predicted gene 9706 Neighboring gene cysteine-rich protein 3 Neighboring gene solute carrier family 22 (organic anion transporter), member 7 Neighboring gene predicted gene, 36541

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice. Ishizuka M, et al. Dev Growth Differ, 2016 Sep. PMID 27385512
    2. Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes. Enders A, et al. Proc Natl Acad Sci U S A, 2014 Mar 25. PMID 24616512, Free PMC Article
    3. Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus. Pioli PD, et al. J Immunol, 2014 Sep 1. PMID 25057009, Free PMC Article
    4. Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis. Ishizuka M, et al. Biochem Biophys Res Commun, 2003 Feb 21. PMID 12589823
    5. The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. Inoue A, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873617

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ampk regulates IgD expression but not energy stress with B cell activation.
      Title: Ampk regulates IgD expression but not energy stress with B cell activation.
    2. Zfp318 is expressed as a functional protein in testicular germ cells and plays an important role in meiosis during spermatogenesis.
      Title: Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice.
    3. This finding indicates that Zfp318, in a novel manner, functions by repressing recognition of the transcriptional termination site at the 3' end of the terminal IgM-encoding exon
      Title: Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus.
    4. findings identify ZFP318 as a crucial factor regulating the expression of the two major antibody isotypes on the surface of most mature B cells
      Title: Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.
    5. Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
      Title: Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
    6. in the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively
      Title: Opposite effects of alternative TZF spliced variants on androgen receptor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 318
    Names
    testicular zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021346.2 → NP_067321.2  zinc finger protein 318 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC151275, CT009572
      Consensus CDS
      CCDS28826.2
      Related
      ENSMUSP00000116544.2, ENSMUST00000138127.8
      Conserved Domains (4) summary
      smart00451
      Location:1085 → 1114
      ZnF_U1; U1-like zinc finger
      pfam15087
      Location:18 → 127
      DUF4551; Protein of unknown function (DUF4551)
      cd16269
      Location:971 → 982
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:899 → 996
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_207671.4 → NP_997554.2  zinc finger protein 318 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC151275, AK157779, AW457229, BU704885, CD542244, CJ161473, CT009572
      Consensus CDS
      CCDS28827.2
      UniProtKB/Swiss-Prot
      B0V2M3, B9EK88, Q3TZL5, Q8BMX9, Q99PP2, Q9JJ01
      Related
      ENSMUSP00000109109.2, ENSMUST00000113481.9
      Conserved Domains (3) summary
      smart00451
      Location:1155 → 1189
      ZnF_U1; U1-like zinc finger
      cl26511
      Location:899 → 1031
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28033
      Location:18 → 142
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46694444..46731846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246554.4 → XP_011244856.1  zinc finger protein 318 isoform X1

      Conserved Domains (2) summary
      PTZ00121
      Location:687 → 819
      PTZ00121; MAEBL; Provisional
      smart00451
      Location:943 → 977
      ZnF_U1; U1-like zinc finger

    RNA

    1. XR_385351.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PP2.3 GenPept UniProtKB/Swiss-Prot:Q99PP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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