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    Larp7 La ribonucleoprotein 7, transcriptional regulator [ Mus musculus (house mouse) ]

    Gene ID: 28036, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Larp7provided by MGI
    Official Full Name
    La ribonucleoprotein 7, transcriptional regulatorprovided by MGI
    Primary source
    MGI:MGI:107634
    See related
    Ensembl:ENSMUSG00000027968 AllianceGenome:MGI:107634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D3Wsu161e; C330027G06Rik
    Summary
    Enables U6 snRNA binding activity. Involved in ncRNA metabolic process; regulation of mRNA splicing, via spliceosome; and spermatogenesis. Acts upstream of or within several processes, including germ cell proliferation; negative regulation of chromatin binding activity; and positive regulation of G1/S transition of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including central nervous system; gonad; liver; sensory organ; and spleen. Orthologous to human LARP7 (La ribonucleoprotein 7, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 27.9), testis adult (RPKM 22.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 G2; 3 56.54 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127330363..127346998, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127536714..127553349, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ankyrin 2, brain Neighboring gene predicted gene, 52631 Neighboring gene STARR-seq mESC enhancer starr_08950 Neighboring gene predicted gene, 35535 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127256185-127256372 Neighboring gene predicted gene, 51018 Neighboring gene microRNA 302b Neighboring gene microRNA 302c Neighboring gene microRNA 302a Neighboring gene microRNA 302d Neighboring gene microRNA 367 Neighboring gene STARR-seq mESC enhancer starr_08956 Neighboring gene zinc finger, GRF-type containing 1 Neighboring gene predicted gene, 40147

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-κB signaling pathway. Li N, et al. Allergol Immunopathol (Madr), 2023. PMID 36617833
    2. LARP7 Suppresses Endothelial-to-Mesenchymal Transition by Coupling With TRIM28. Liang X, et al. Circ Res, 2021 Oct 15. PMID 34503347
    3. Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism. Alazami AM, et al. Hum Mutat, 2012 Oct. PMID 22865833
    4. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation. Dai Q, et al. Cell Rep, 2014 May 8. PMID 24768001
    5. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Zhang F, et al. Cell Rep, 2020 Jul 28. PMID 32726637

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice.
      Title: LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice.
    2. LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-kappaB signaling pathway.
      Title: LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-κB signaling pathway.
    3. LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
      Title: LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
    4. LARP7 Suppresses Endothelial-to-Mesenchymal Transition by Coupling With TRIM28.
      Title: LARP7 Suppresses Endothelial-to-Mesenchymal Transition by Coupling With TRIM28.
    5. LARP7 regulates U6 2'-O-methylation in male germ cells which is required for splicing fidelity and spermatogenesis in mice.
      Title: LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice.
    6. LARP7 interacts with TUT1 nucleotidyl transferase to regulate Lin28 expression.
      Title: Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U6 snRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in U6 2'-O-snRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in U6 2'-O-snRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in box C/D sno(s)RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in box C/D sno(s)RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of chromatin binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 7SK snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    la-related protein 7
    Names
    La ribonucleoprotein domain family, member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138593.2 → NP_613059.2  la-related protein 7

      See identical proteins and their annotated locations for NP_613059.2

      Status: VALIDATED

      Source sequence(s)
      AK082815, AK162147, BM946683, BU701061, BY269910
      Consensus CDS
      CCDS38626.1
      UniProtKB/Swiss-Prot
      Q05CL8, Q3TSC2, Q8K2Y6, Q8VDW3, Q9CSI2, Q9CSI9, Q9CUQ5
      UniProtKB/TrEMBL
      I3PQW3
      Related
      ENSMUSP00000029588.6, ENSMUST00000029588.10
      Conserved Domains (3) summary
      cd08032
      Location:25 → 105
      LARP_7; La RNA-binding domain of La-related protein 7
      cd12290
      Location:120 → 199
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:442 → 540
      RRM_3; RNA binding motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      127330363..127346998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05CL8.2 GenPept UniProtKB/Swiss-Prot:Q05CL8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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