Pacsin2 protein kinase C and casein kinase substrate in neurons 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pacsin2provided by MGI
Official Full Name: protein kinase C and casein kinase substrate in neurons 2provided by MGI
Primary source: MGI:MGI:1345153
See related: Ensembl:ENSMUSG00000016664 AllianceGenome:MGI:1345153
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SdpII
Summary: Enables cytoskeletal protein binding activity and lipid binding activity. Involved in cell projection morphogenesis; modulation of chemical synaptic transmission; and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in caveola; cell-cell junction; and cytosol. Is extrinsic component of membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; aorta; eye; genitourinary system; and thymus. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 34.6), kidney adult (RPKM 33.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 39.4 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (83259812..83348800, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (83375607..83464610, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PACSIN2 regulates platelet integrin beta1 hemostatic function.
Title: PACSIN2 regulates platelet integrin β1 hemostatic function.
PACSIN proteins in vivo: Roles in development and physiology.
Title: PACSIN proteins in vivo: Roles in development and physiology.
Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes.
Title: Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes.
Pacsin 2 is necessary for cardiac development and function in mouse embryos.
Title: Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.
Pacsin 2 contributes to kidney development and repair in a nephron-specific manner.
Title: The cytoplasmic protein Pacsin 2 in kidney development and injury repair.
syndapin II binds to both flat and curved membranes in vivo and that it plays an important role in caveolar shaping, a role that it shares with PTRF/cavin 1.
Title: Ultrastructural freeze-fracture immunolabeling identifies plasma membrane-localized syndapin II as a crucial factor in shaping caveolae.
important role in the formation of plasma membrane caveolae
Title: Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis.
These findings suggest a novel function for PACSIN proteins 1, 2, and 3 in dynamic microtubule nucleation.
Title: PACSIN proteins bind tubulin and promote microtubule assembly.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126385 (e-PCR)
- UniSTS:163093

UniSTS:489243 (e-PCR)
- UniSTS:489243

RH135963 (e-PCR)
- UniSTS:209959

NoName (e-PCR)
- UniSTS:495064

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in caveola assembly	ISO Inferred from Sequence Orthology more info
involved_in caveolin-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in cell projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane tubulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane tubulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IC Inferred by Curator more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
NOT located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein kinase C and casein kinase substrate in neurons protein 2

Names: Syndapin II; syndapin-2; syndapin-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159509.2 → NP_001152981.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

See identical proteins and their annotated locations for NP_001152981.1

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

Consensus CDS

CCDS27701.1

UniProtKB/Swiss-Prot

Q9WVE8

UniProtKB/TrEMBL

Q3TDA7

Related

ENSMUSP00000131504.2, ENSMUST00000171436.8

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:429 → 484

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:348 → 428

NPF; Rabosyn-5 repeating NPF sequence-motif
NM_001159510.2 → NP_001152982.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

See identical proteins and their annotated locations for NP_001152982.1

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

Consensus CDS

CCDS27701.1

UniProtKB/Swiss-Prot

Q9WVE8

UniProtKB/TrEMBL

Q3TDA7

Related

ENSMUSP00000155334.2, ENSMUST00000231184.2

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:429 → 484

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:348 → 428

NPF; Rabosyn-5 repeating NPF sequence-motif
NM_001358641.2 → NP_001345570.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:431 → 486

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:342 → 430

NPF; Rabosyn-5 repeating NPF sequence-motif
NM_001358642.2 → NP_001345571.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:390 → 445

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
NM_001358643.2 → NP_001345572.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:388 → 443

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
NM_001358644.2 → NP_001345573.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:390 → 445

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
NM_001411850.1 → NP_001398779.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

UniProtKB/Swiss-Prot

Q9WVE8

UniProtKB/TrEMBL

Q3TDA7
NM_001411851.1 → NP_001398780.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

UniProtKB/Swiss-Prot

Q9WVE8

UniProtKB/TrEMBL

Q3TDA7
NM_001411852.1 → NP_001398781.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC165945, AL583889
NM_011862.4 → NP_035992.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

See identical proteins and their annotated locations for NP_035992.1

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

Consensus CDS

CCDS27701.1

UniProtKB/Swiss-Prot

Q9WVE8

UniProtKB/TrEMBL

Q3TDA7

Related

ENSMUSP00000130098.2, ENSMUST00000165095.9

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:429 → 484

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:348 → 428

NPF; Rabosyn-5 repeating NPF sequence-motif

RNA

NR_177947.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC165945, AL583889

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

83259812..83348800 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245633.4 → XP_011243935.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

See identical proteins and their annotated locations for XP_011243935.1

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:431 → 486

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:342 → 430

NPF; Rabosyn-5 repeating NPF sequence-motif
XM_006520981.4 → XP_006521044.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

See identical proteins and their annotated locations for XP_006521044.1

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:431 → 486

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:342 → 430

NPF; Rabosyn-5 repeating NPF sequence-motif
XM_036159409.1 → XP_036015302.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:431 → 486

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:342 → 430

NPF; Rabosyn-5 repeating NPF sequence-motif
XM_006520980.4 → XP_006521043.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

See identical proteins and their annotated locations for XP_006521043.1

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:431 → 486

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:342 → 430

NPF; Rabosyn-5 repeating NPF sequence-motif
XM_006520983.5 → XP_006521046.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

See identical proteins and their annotated locations for XP_006521046.1

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:431 → 486

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:342 → 430

NPF; Rabosyn-5 repeating NPF sequence-motif
XM_006520982.2 → XP_006521045.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

See identical proteins and their annotated locations for XP_006521045.1

Conserved Domains (3) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:431 → 486

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

pfam16601
Location:342 → 430

NPF; Rabosyn-5 repeating NPF sequence-motif