Conserved Protein Domain Family
NPF
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pfam16601: NPF (this model, PSSM-Id:374661 is obsolete and has been replaced by 406900)
Rabosyn-5 repeating NPF sequence-motif
NPF is a natively unstructured but well-conserved region found in eukaryotic proteins of the Rabenosyn-5 type, wherein the sequence motif arginine-proline-phenylalanine followed by several glutamates and aspartates is repeated up to four times along the sequence. NPF lies between the two Rab-binding domains, for Rab-4 and Rab-5, at the C-terminal end of these proteins. Rabosyn-5 (or rabenosyn) is also involved in cell-polarity determination in developing wing epithelia of Drosophila, when the NPF-motif may be implicated. These NPF motifs create a region of strong positive surface potential which appear to bind Eps15 homology, EH or EF-hand, domains on proteins involved in vesicle trafficking.
Links
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Statistics
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PSSM-Id: 374661
Aligned: 16 rows
Threshold Bit Score: 168.027
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003217831 549 SLDFREAKHSTVETGKERTNQIAQALDLDTTQNRSNPGSKTPLPCGGGKaPTRDSPIFPAQLQRIPQHDGVTGQNVTVPL 628 green anole
XP_001376548 545 SLDFKD-KLFHWESGIDSPSQTAHILDLGPSLVRHNAVLKSPSPSSGQE-PNKEKPVFSTIAQEILQQ------NEVVSL 616 gray short-tail...
XP_003762510 545 SLDFKD-KLFQQEPGMEPQNQIAHVLDLGPSLVRNNVTFKSPSPNSVQE-PNKEKSMFPMLGQEIVKQSTGVHQNEVASL 622 Tasmanian devil
XP_004944786 543 SLDFREGKQHQYEAAKENQNLLAHGLDLDITQVKGNRSFET---TAVQQlPAKEYLIFPVRHQNTPRC--DKDQNQAACL 617 chicken
XP_002713085 548 SLDFREIGPFQLEPSREPRPHLAYALDLGPSSGQSSTAPTTSSPSPAQE-PNLVWAGPSACGQECPPQGPVSQPNEVPSL 626 rabbit
ELW46963     546 SLDFREVSPFQLEPSREPRGHLAYALDLGPSPARGDVASHNPSPGSAAE-PIRVWAGRLALGQEHFPQSSVSQQNEVSSL 624 Chinese tree shrew
EHA98693     638 ALDSREAAPFLLEPSRGPRPHPAFALELGSSSGSG-MAPETPSPCAV-------W----ALSQESLHQSTEPQQNDC-AL 704 naked mole-rat
EGV97724     544 ALDLRDVVPFQLDPNRGPHSDLAYALDQDFSPVQGSTAPNTLSPGSTLA-PIHLWSGPPALGQELLLQNTMSQQSDKTSL 622 Chinese hamster
XP_012664706 548 SLDFREIRPFQLQAGREPRTHLAYALDLGSSPVQSSTAPKTPSPCSAQE-PVQIWSGPPVLGQEFLPQSSISQQDEVPSL 626 small-eared galago
XP_027323603 439 SLDFREVKQHQHEVTKENQNLIAHGLDLDSTQMKGNPGSET---TAVQQlPAKDNFIFPVKPQNVPQH--DKDQNRAACL 513 mallard

XP_003217831 629 NPFENEEVVTSLKM-EPDNPFAEDPSPVtplPIQVLHsskKEYNPFEDEDFHQAN----------GAAVSAPNPFEDAAG 697 green anole
XP_001376548 617 NPFEEEEVSSPGDE-GLTNPFAEDVSHGgcsPPSAVAsvkKEYNPFEDEEDEpv----------gDANGPLLNPFEEDEQ 685 gray short-tail...
XP_003762510 623 NPFEEEEISSPGNE-DFTNPFAEDVAHGgssPHSAVPsvkKEYNPFEDEEDEPPg----------DADGPILNPFEV-DD 690 Tasmanian devil
XP_004944786 618 NPFE-DDADTPLSEeDPTNPFAKDVSQPisfSNTALQsdkKEYNPFENEEEGEQTs---------GASVSTLNPFEE-DE 686 chicken
XP_002713085 627 NPFEEEDLASPREE-DPTHPPTAEVSVS---PAAPVP---KEYNPFEEEEEEVVAgnp-----ftSPDSPAPNPFEEEEE 694 rabbit
ELW46963     625 NPFDEDELPSPLDA-GPTSPPA-EASFG---LSTRVP---REYNPFEEEEEEVPGnp------ftDPDSPPPNPFDEEEE 690 Chinese tree shrew
EHA98693     705 NSFSRDFFSSPAVV-QAKLP--------------------REYNPFEEEEEEEEEavaag-npftSPDSPAPNPFDSPAP 762 naked mole-rat
EGV97724     623 NPFD-EDLSSPAE--GATSPAAAEAFLG---PSAPVT---REYNPFEEDAEEEEAgesgagnpftDPNSPAPNPFDED-- 691 Chinese hamster
XP_012664706 627 NPFDEEDFSSPTEE-ATASAPATELSSG---PSAYIP---KVYNPFEEEEEEEAAaen----pftHPDSPVPNPFDEEDE 695 small-eared galago
XP_027323603 514 NPFE-DETDTPLSEeDPANPFAKDISPLisfSNAIVQsdkKEYNPFENEEDEQTN----------GASVSTSNPFEE-DE 581 mallard

XP_003217831 698 NPFHS--------PVSRQESGNPFEEspSSSMNPFEVddDDDNEVLGEDIIEEE 743 green anole
XP_001376548 686 LPYPK--------HSSPPHPGNPFEE--PASTNPFDM--E-DSEPDGEELIEEE 726 gray short-tailed opossum
XP_003762510 691 LPYQK--------HSSPPNPGNPFEE--PVSTNPFDI--D-DSETEREELIEEE 731 Tasmanian devil
XP_004944786 687 NPFQK--------SGSNWNSGNPFEE--SSSTNPFEV--EDVSEILREEAIEEE 728 chicken
XP_002713085 695 SPHLR--------PSSPPVPGNPFEE--PAGPNPFEV--DSDSGAEAEEPIEEE 736 rabbit
ELW46963     691 HPHQS--------PSSPPVPGNPFVK--AVCTNPFET--DSDSGPEAEEPIEEE 732 Chinese tree shrew
EHA98693     763 NPFEDgndvpnrsPASPPVPSNPFEE--PTGTNPFEV--DSDSCPEAEEPIEED 812 naked mole-rat
EGV97724     692 -DHPR--------PASPPAPGNPFEE--CPCTNPFEV--DSDSGTEAEEHIEEE 732 Chinese hamster
XP_012664706 696 HPHPR--------SSSPLVPGNPFEE--PTCTNPFEV--DSDSGPEAEELIEEE 737 small-eared galago
XP_027323603 582 NPCQK--------SGG--NSGNPFEE--GSSTNPFEV--EDGNEISEEEAIEEE 621 mallard
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