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    Arih1 ariadne RBR E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 23806, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Arih1provided by MGI
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:1344363
    See related
    Ensembl:ENSMUSG00000025234 AllianceGenome:MGI:1344363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ari; Ari1; Hari; Hhari; Uip77; Ubch7bp
    Summary
    Predicted to enable enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in Lewy body and nuclear body. Predicted to be part of Cul3-RING ubiquitin ligase complex; Cul4A-RING E3 ubiquitin ligase complex; and SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in hippocampus. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.4), testis adult (RPKM 8.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 B; 9 32.01 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59295837..59395469, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59388554..59488186, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:59138959-59139219 Neighboring gene ADP-dependent glucokinase Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:59201235-59201388 Neighboring gene STARR-seq mESC enhancer starr_24298 Neighboring gene STARR-seq mESC enhancer starr_24299 Neighboring gene STARR-seq mESC enhancer starr_24300 Neighboring gene STARR-seq mESC enhancer starr_24301 Neighboring gene STARR-seq mESC enhancer starr_24302 Neighboring gene ribosomal protein S11, pseudogene 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:59334521-59334822 Neighboring gene predicted gene, 20199 Neighboring gene predicted gene, 33180 Neighboring gene transmembrane protein 202 Neighboring gene hexosaminidase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain. González-Barbosa E, et al. J Biochem Mol Toxicol, 2017 Oct. PMID 28621812, Free PMC Article
    2. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Xiong TC, et al. Nat Commun, 2022 Oct 10. PMID 36217001, Free PMC Article
    3. The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest. von Stechow L, et al. Mol Cell Biol, 2015 Apr. PMID 25624349, Free PMC Article
    4. Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. Kathania M, et al. J Immunol, 2015 Mar 1. PMID 25632008
    5. nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development. Haraguchi S, et al. Mech Dev, 2003 Jun. PMID 12834871

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.
      Title: The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.
    2. 2,3,7,8-tetrachlorodibenzo-p-dioxin promotes the aryl hydrocarbon receptor binding to Ubch7 gene promoter as well as its transactivation, resulting in an induction of UbcH7 levels in the olfactory bulb, ventral midbrain, hippocampus, striatum, cerebral cortex, brain stem, and medulla oblongata.
      Title: TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain.
    3. DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with 4EHP. In turn, this causes 4EHP recruitment to the mRNA cap, where it is known to compete with eIF4E.
      Title: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
    4. Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
      Title: Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Lewy body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ARIH1
    Names
    ARI-1
    RING-type E3 ubiquitin transferase ARIH1
    UbcH7-binding protein
    UbcM4-interacting protein 77
    ariadne 1
    ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1
    protein ariadne-1 homolog
    ubiquitin-conjugating enzyme E2-binding protein 1
    NP_064311.2
    XP_006511203.1
    XP_006511204.1
    XP_011241041.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019927.2 → NP_064311.2  E3 ubiquitin-protein ligase ARIH1

      See identical proteins and their annotated locations for NP_064311.2

      Status: VALIDATED

      Source sequence(s)
      AJ130977, AK032640, AK047617, AW125831, CA328699, CJ176800, CK633971, CV555932
      Consensus CDS
      CCDS52817.1
      UniProtKB/Swiss-Prot
      E9Q1X3, Q6PF92, Q8CFJ4, Q9Z1K5
      UniProtKB/TrEMBL
      H9KV21
      Related
      ENSMUSP00000126531.2, ENSMUST00000171975.8
      Conserved Domains (3) summary
      smart00647
      Location:255 → 315
      IBR; In Between Ring fingers
      cd16626
      Location:183 → 240
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:337 → 377
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      59295837..59395469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511140.4 → XP_006511203.1  E3 ubiquitin-protein ligase ARIH1 isoform X1

      UniProtKB/TrEMBL
      H9KV21
      Conserved Domains (3) summary
      smart00647
      Location:196 → 256
      IBR; In Between Ring fingers
      cd16626
      Location:124 → 181
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:278 → 318
      IBR; IBR domain, a half RING-finger domain

    2. XM_006511141.3 → XP_006511204.1  E3 ubiquitin-protein ligase ARIH1 isoform X3

      UniProtKB/TrEMBL
      H9KV21
      Conserved Domains (3) summary
      smart00647
      Location:165 → 225
      IBR; In Between Ring fingers
      cd16626
      Location:93 → 150
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:247 → 287
      IBR; IBR domain, a half RING-finger domain

    3. XM_011242739.3 → XP_011241041.1  E3 ubiquitin-protein ligase ARIH1 isoform X2

      UniProtKB/TrEMBL
      H9KV21
      Conserved Domains (3) summary
      smart00647
      Location:173 → 233
      IBR; In Between Ring fingers
      cd16626
      Location:101 → 158
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:255 → 295
      IBR; IBR domain, a half RING-finger domain

    RNA

    1. XR_004935434.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1K5.3 GenPept UniProtKB/Swiss-Prot:Q9Z1K5

    Gene LinkOut

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