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    Zyg11a zyg-11 family member A, cell cycle regulator [ Mus musculus (house mouse) ]

    Gene ID: 230590, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zyg11aprovided by MGI
    Official Full Name
    zyg-11 family member A, cell cycle regulatorprovided by MGI
    Primary source
    MGI:MGI:2446208
    See related
    Ensembl:ENSMUSG00000034645 AllianceGenome:MGI:2446208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human ZYG11A (zyg-11 family member A, cell cycle regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 1.6), mammary gland adult (RPKM 1.2) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C7; 4 50.31 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108037442..108075285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108180245..108218088, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54248 Neighboring gene STARR-seq mESC enhancer starr_11032 Neighboring gene enoyl Coenzyme A hydratase domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_11034 Neighboring gene predicted gene, 54249 Neighboring gene zyg-ll family member B, cell cycle regulator Neighboring gene STARR-positive B cell enhancer ABC_E2701 Neighboring gene STARR-seq mESC enhancer starr_11037 Neighboring gene STARR-seq mESC enhancer starr_11038 Neighboring gene STARR-positive B cell enhancer ABC_E11249 Neighboring gene STARR-positive B cell enhancer ABC_E10246 Neighboring gene STARR-positive B cell enhancer ABC_E7979 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:108000774-108000883 Neighboring gene STARR-positive B cell enhancer ABC_E2702 Neighboring gene cytochrome c oxidase assembly factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein zyg-11 homolog A
    Names
    zyg-11 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167936.3 → NP_001161408.2  protein zyg-11 homolog A

      Status: VALIDATED

      Source sequence(s)
      BX293563
      Consensus CDS
      CCDS51256.2
      UniProtKB/TrEMBL
      A0A217FL76, F8WHU3
      Related
      ENSMUSP00000102301.3, ENSMUST00000106690.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      108037442..108075285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502976.4 → XP_006503039.1  protein zyg-11 homolog A isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VNL1, F8WHU3
      Related
      ENSMUSP00000152477.2, ENSMUST00000223127.2
      Conserved Domains (2) summary
      COG4886
      Location:156 → 294
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00034
      Location:158 → 182
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. XM_017320136.1 → XP_017175625.1  protein zyg-11 homolog A isoform X2

      UniProtKB/Swiss-Prot
      A2BFL2, Q8VC01
      Conserved Domains (2) summary
      COG4886
      Location:56 → 194
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00034
      Location:58 → 82
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2BFL2.1 GenPept UniProtKB/Swiss-Prot:A2BFL2

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