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Conserved domains on  [gi|1039767375|ref|XP_017175625|]
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protein zyg-11 homolog A isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
56-231 7.33e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 7.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767375  56 KNLQCLVLDS---VSIPPnsglvALSHFTGLHTLSVANVSFcnEDLVSVSQLPNLGSLDISNTLVTNISALLSCKNrLRS 132
Cdd:COG4886   205 TNLEELDLSGnqlTDLPE-----PLANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQLTDLPPLANLTN-LKT 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767375 133 LTMHY--LKCLAMNSPQVLAVIRQLKCLLHLDISDHQQLRSDLAFYLLQQKDILPNLTSLDISGGTDVTDQAVESFLQHR 210
Cdd:COG4886   277 LDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356

                         170       180
                  ....*....|....*....|.
gi 1039767375 211 PAMRFVGLLYTDAGYSDFFTA 231
Cdd:COG4886   357 NLLSLLLTLLLTLGLLGLLEA 377
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-231 7.33e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 7.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767375  56 KNLQCLVLDS---VSIPPnsglvALSHFTGLHTLSVANVSFcnEDLVSVSQLPNLGSLDISNTLVTNISALLSCKNrLRS 132
Cdd:COG4886   205 TNLEELDLSGnqlTDLPE-----PLANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQLTDLPPLANLTN-LKT 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767375 133 LTMHY--LKCLAMNSPQVLAVIRQLKCLLHLDISDHQQLRSDLAFYLLQQKDILPNLTSLDISGGTDVTDQAVESFLQHR 210
Cdd:COG4886   277 LDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356

                         170       180
                  ....*....|....*....|.
gi 1039767375 211 PAMRFVGLLYTDAGYSDFFTA 231
Cdd:COG4886   357 NLLSLLLTLLLTLGLLGLLEA 377
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-231 7.33e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 7.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767375  56 KNLQCLVLDS---VSIPPnsglvALSHFTGLHTLSVANVSFcnEDLVSVSQLPNLGSLDISNTLVTNISALLSCKNrLRS 132
Cdd:COG4886   205 TNLEELDLSGnqlTDLPE-----PLANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQLTDLPPLANLTN-LKT 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767375 133 LTMHY--LKCLAMNSPQVLAVIRQLKCLLHLDISDHQQLRSDLAFYLLQQKDILPNLTSLDISGGTDVTDQAVESFLQHR 210
Cdd:COG4886   277 LDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356

                         170       180
                  ....*....|....*....|.
gi 1039767375 211 PAMRFVGLLYTDAGYSDFFTA 231
Cdd:COG4886   357 NLLSLLLTLLLTLGLLGLLEA 377
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-194 3.37e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767375  56 KNLQCLVLDS---VSIPPnsglvALSHFTGLHTLSVANVSFcnEDL-VSVSQLPNLGSLDISNTLVTNISALLSCKNRLR 131
Cdd:COG4886   113 TNLESLDLSGnqlTDLPE-----ELANLTNLKELDLSNNQL--TDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039767375 132 SLTMHYLKCLAMNSPqvlavIRQLKCLLHLDISDHQ--QLRSDLAFyllqqkdiLPNLTSLDISG 194
Cdd:COG4886   186 ELDLSNNQITDLPEP-----LGNLTNLEELDLSGNQltDLPEPLAN--------LTNLETLDLSN 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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