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    Coq3 coenzyme Q3 methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 230027, updated on 24-Apr-2024

    Summary

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    Official Symbol
    Coq3provided by MGI
    Official Full Name
    coenzyme Q3 methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:101813
    See related
    Ensembl:ENSMUSG00000028247 AllianceGenome:MGI:101813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732433J24
    Summary
    Predicted to enable O-methyltransferase activity and hexaprenyldihydroxybenzoate methyltransferase activity. Predicted to be involved in several processes, including glycerol metabolic process; regulation of ubiquinone biosynthetic process; and ubiquinone biosynthetic process. Located in mitochondrion. Orthologous to human COQ3 (coenzyme Q3, methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 5.7), placenta adult (RPKM 4.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A3; 4 9.11 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21879646..21912163)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21879646..21912163)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09733 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 Neighboring gene ubiquitin specific petidase 45 Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene PNN interacting serine/arginine-rich Neighboring gene STARR-seq mESC enhancer starr_09735 Neighboring gene STARR-seq mESC enhancer starr_09736 Neighboring gene failed axon connections homolog Neighboring gene WEE1 homolog 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/- mice. Lapointe J, et al. J Cell Biol, 2012 Oct 15. PMID 23045551, Free PMC Article
    2. Involvement of retinoid X receptor alpha in coenzyme Q metabolism. Bentinger M, et al. J Mol Biol, 2003 Feb 21. PMID 12581641
    3. Ubiquinone biosynthesis in eukaryotic cells: tissue distribution of mRNA encoding 3,4-dihydroxy-5-polyprenylbenzoate methyltransferase in the rat and mapping of the COQ3 gene to mouse chromosome 4. Marbois BN, et al. Arch Biochem Biophys, 1994 Aug 15. PMID 8053692
    4. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues. Parrado-Fernández C, et al. Free Radic Biol Med, 2011 Jun 15. PMID 21447381, Free PMC Article
    5. Assignment of the mouse sterol carrier protein gene (Scp2) to chromosome 4. Welch CL, et al. Mamm Genome, 1996 Aug. PMID 8678992

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues
      Title: Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-demethylubiquinol-n 3-O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquinone biosynthesis complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinone biosynthesis O-methyltransferase, mitochondrial
    Names
    2-polyprenyl-6-hydroxyphenol methylase
    2-polyprenyl-6-hydroxyphenyl methylase
    3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
    3-demethylubiquinol 3-O-methyltransferase
    3-demethylubiquinone-9 3-methyltransferase
    Coenzyme Q (ubiquinone)
    DHHB methyltransferase
    DHHB-MT
    DHHB-MTase
    coenzyme Q3 homolog, methyltransferase
    dihydroxyhexaprenylbenzoate methyltransferase
    hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
    polyprenyldihydroxybenzoate methyltransferase
    NP_001343277.1
    NP_766275.1
    XP_036019878.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356348.2 → NP_001343277.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772187
      UniProtKB/TrEMBL
      Q3UQM8
      Conserved Domains (1) summary
      TIGR01983
      Location:38 → 268
      UbiG; ubiquinone biosynthesis O-methyltransferase

    2. NM_001429581.1 → NP_001416510.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772187

    3. NM_001429582.1 → NP_001416511.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772187

    4. NM_001429583.1 → NP_001416512.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772187

    5. NM_172687.3 → NP_766275.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_766275.1

      Status: VALIDATED

      Source sequence(s)
      AL772187
      Consensus CDS
      CCDS18003.1
      UniProtKB/Swiss-Prot
      Q3TCX5, Q6P918, Q8BM28, Q8BMS4
      UniProtKB/TrEMBL
      Q3UQM8
      Related
      ENSMUSP00000029909.3, ENSMUST00000029909.3
      Conserved Domains (2) summary
      TIGR01983
      Location:97 → 327
      UbiG; ubiquinone biosynthesis O-methyltransferase
      pfam08241
      Location:152 → 251
      Methyltransf_11; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      21879646..21912163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163985.1 → XP_036019878.1  ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q3UQM8
      Conserved Domains (1) summary
      TIGR01983
      Location:38 → 268
      UbiG; ubiquinone biosynthesis O-methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMS4.1 GenPept UniProtKB/Swiss-Prot:Q8BMS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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