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Conserved domains on  [gi|27369992|ref|NP_766275|]
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ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform 1 [Mus musculus]

Protein Classification

bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG( domain architecture ID 11493423)

bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG is a class I SAM-dependent methyltransferase that catalyzes both methylation steps in ubiquinone biosynthesis

CATH:  3.40.50.150
EC:  2.1.1.222|2.1.1.64
Gene Ontology:  GO:0102208|GO:0008425|GO:0008689|GO:0032259|GO:0006744
PubMed:  10419476|11583838

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 97-327 8.00e-120

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


:

Pssm-ID: 273910  Cd Length: 224  Bit Score: 345.82  E-value: 8.00e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992    97 EVKNFQALAHTWWDEYGKFAPLHSMNDLRVPFIRDNLLKtsashHPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGID 176
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIRK-----NFKNPLDGLRVLDVGCGGGLLSEPLARLGANVTGID 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   177 PVAENIKIAQHHKSFDPVLdkrIQYKVCSLEEAVDESAECFDAVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFITTVNK 256
Cdd:TIGR01983  76 ASEENIEVAKLHAKKDPLQ---IDYRCTTVEDLAEKKAGSFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINR 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27369992   257 TQLSYALGIVFAEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGLVYNPFSGYWHWSENTSLNY 327
Cdd:TIGR01983 153 TPKSYLLAIVGAEYILRIVPKGTHDWEKFIKPSELLSWLESAGLRVKDIKGLVYNPIKNTWKLSKDTDVNY 223
 
Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 97-327 8.00e-120

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 345.82  E-value: 8.00e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992    97 EVKNFQALAHTWWDEYGKFAPLHSMNDLRVPFIRDNLLKtsashHPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGID 176
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIRK-----NFKNPLDGLRVLDVGCGGGLLSEPLARLGANVTGID 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   177 PVAENIKIAQHHKSFDPVLdkrIQYKVCSLEEAVDESAECFDAVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFITTVNK 256
Cdd:TIGR01983  76 ASEENIEVAKLHAKKDPLQ---IDYRCTTVEDLAEKKAGSFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINR 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27369992   257 TQLSYALGIVFAEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGLVYNPFSGYWHWSENTSLNY 327
Cdd:TIGR01983 153 TPKSYLLAIVGAEYILRIVPKGTHDWEKFIKPSELLSWLESAGLRVKDIKGLVYNPIKNTWKLSKDTDVNY 223
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 87-333 1.54e-75

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 236.55  E-value: 1.54e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   87 STSQTTVDSREVKNFQALAHTWWDEYGKFAPLHSMNDLRVPFIRDNLLKT-SASHHPGKPLSGMKILDVGCGGGLLTEPL 165
Cdd:PLN02396  70 TSTTTSLNEDELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTLCRHfSKDPSSAKPFEGLKFIDIGCGGGLLSEPL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  166 GRLGASVVGIDPVAENIKIAQHHKSFDPVLDKrIQYkVCSLEEAVDESAECFDAVVASEVVEHVSHLEMFIQCCYQVLKP 245
Cdd:PLN02396 150 ARMGATVTGVDAVDKNVKIARLHADMDPVTST-IEY-LCTTAEKLADEGRKFDAVLSLEVIEHVANPAEFCKSLSALTIP 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  246 GGSLFITTVNKTQLSYALGIVFAEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGLVYNPFSGYWHWSENTSL 325
Cdd:PLN02396 228 NGATVLSTINRTMRAYASTIVGAEYILRWLPKGTHQWSSFVTPEELSMILQRASVDVKEMAGFVYNPITGRWLLSDDISV 307


                 ....*...
gi 27369992  326 NYAAHAVR 333
Cdd:PLN02396 308 NYIAYGTK 315
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 146-255 4.49e-32

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 117.04  E-value: 4.49e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 146 LSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHksfdpVLDKRIQYKVCSLEEaVDESAECFDAVVASEV 225
Cdd:COG2227  23 PAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARER-----AAELNVDFVQGDLED-LPLEDGSFDLVICSEV 96

                        90       100       110
                ....*....|....*....|....*....|
gi 27369992 226 VEHVSHLEMFIQCCYQVLKPGGSLFITTVN 255
Cdd:COG2227  97 LEHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 152-251 1.73e-23

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 93.11  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   152 LDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVldkriQYKVCSLEEaVDESAECFDAVVASEVVEHVSH 231
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGL-----TFVVGDAED-LPFPDNSFDLVLSSEVLHHVED 74

                          90       100
                  ....*....|....*....|
gi 27369992   232 LEMFIQCCYQVLKPGGSLFI 251
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 150-254 1.08e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 72.08  E-value: 1.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 150 KILDVGCGGGLLTEPLGRL-GASVVGIDPVAENIKIAQhhKSFDPVLDKRIQYKVCSLEEAVDESAECFDAVVASEVVEH 228
Cdd:cd02440   1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELAR--KAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHH 78

                        90       100
                ....*....|....*....|....*..
gi 27369992 229 VSHLEM-FIQCCYQVLKPGGSLFITTV 254
Cdd:cd02440  79 LVEDLArFLEEARRLLKPGGVLVLTLV 105
 
Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 97-327 8.00e-120

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 345.82  E-value: 8.00e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992    97 EVKNFQALAHTWWDEYGKFAPLHSMNDLRVPFIRDNLLKtsashHPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGID 176
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIRK-----NFKNPLDGLRVLDVGCGGGLLSEPLARLGANVTGID 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   177 PVAENIKIAQHHKSFDPVLdkrIQYKVCSLEEAVDESAECFDAVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFITTVNK 256
Cdd:TIGR01983  76 ASEENIEVAKLHAKKDPLQ---IDYRCTTVEDLAEKKAGSFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINR 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27369992   257 TQLSYALGIVFAEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGLVYNPFSGYWHWSENTSLNY 327
Cdd:TIGR01983 153 TPKSYLLAIVGAEYILRIVPKGTHDWEKFIKPSELLSWLESAGLRVKDIKGLVYNPIKNTWKLSKDTDVNY 223
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 87-333 1.54e-75

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 236.55  E-value: 1.54e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   87 STSQTTVDSREVKNFQALAHTWWDEYGKFAPLHSMNDLRVPFIRDNLLKT-SASHHPGKPLSGMKILDVGCGGGLLTEPL 165
Cdd:PLN02396  70 TSTTTSLNEDELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTLCRHfSKDPSSAKPFEGLKFIDIGCGGGLLSEPL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  166 GRLGASVVGIDPVAENIKIAQHHKSFDPVLDKrIQYkVCSLEEAVDESAECFDAVVASEVVEHVSHLEMFIQCCYQVLKP 245
Cdd:PLN02396 150 ARMGATVTGVDAVDKNVKIARLHADMDPVTST-IEY-LCTTAEKLADEGRKFDAVLSLEVIEHVANPAEFCKSLSALTIP 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  246 GGSLFITTVNKTQLSYALGIVFAEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGLVYNPFSGYWHWSENTSL 325
Cdd:PLN02396 228 NGATVLSTINRTMRAYASTIVGAEYILRWLPKGTHQWSSFVTPEELSMILQRASVDVKEMAGFVYNPITGRWLLSDDISV 307


                 ....*...
gi 27369992  326 NYAAHAVR 333
Cdd:PLN02396 308 NYIAYGTK 315
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 146-255 4.49e-32

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 117.04  E-value: 4.49e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 146 LSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHksfdpVLDKRIQYKVCSLEEaVDESAECFDAVVASEV 225
Cdd:COG2227  23 PAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARER-----AAELNVDFVQGDLED-LPLEDGSFDLVICSEV 96

                        90       100       110
                ....*....|....*....|....*....|
gi 27369992 226 VEHVSHLEMFIQCCYQVLKPGGSLFITTVN 255
Cdd:COG2227  97 LEHLPDPAALLRELARLLKPGGLLLLSTPN 126
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 148-259 1.21e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 95.06  E-value: 1.21e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 148 GMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKsfdPVLDKRIQYKVCSLeEAVDESAECFDAVVASEVVE 227
Cdd:COG2226  23 GARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERA---AEAGLNVEFVVGDA-EDLPFPDGSFDLVISSFVLH 98

                        90       100       110
                ....*....|....*....|....*....|..
gi 27369992 228 HVSHLEMFIQCCYQVLKPGGSLFITTVNKTQL 259
Cdd:COG2226  99 HLPDPERALAEIARVLKPGGRLVVVDFSPPDL 130
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 152-251 1.73e-23

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 93.11  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   152 LDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVldkriQYKVCSLEEaVDESAECFDAVVASEVVEHVSH 231
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGL-----TFVVGDAED-LPFPDNSFDLVLSSEVLHHVED 74

                          90       100
                  ....*....|....*....|
gi 27369992   232 LEMFIQCCYQVLKPGGSLFI 251
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 151-247 4.52e-22

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 89.16  E-value: 4.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   151 ILDVGCGGGLLTEPL-GRLGASVVGIDPVAENIKIAQHHKSFDPVldkRIQYKVCSLEEaVDESAECFDAVVASEVVEHV 229
Cdd:pfam13649   1 VLDLGCGTGRLTLALaRRGGARVTGVDLSPEMLERARERAAEAGL---NVEFVQGDAED-LPFPDGSFDLVVSSGVLHHL 76

                          90       100
                  ....*....|....*....|
gi 27369992   230 SH--LEMFIQCCYQVLKPGG 247
Cdd:pfam13649  77 PDpdLEAALREIARVLKPGG 96
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 128-304 1.09e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 90.57  E-value: 1.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   128 FIRDNLLKTSAshhpgKPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIA---QHHKSFDPVLDkriqykvc 204
Cdd:pfam13489   8 LLADLLLRLLP-----KLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERAllnVRFDQFDEQEA-------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   205 sleeavDESAECFDAVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFITTVNKTQLSYALgivfAEQIAGIVPKGTHTWek 284
Cdd:pfam13489  75 ------AVPAGKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRL----LLEWPYLRPRNGHIS-- 142

                         170       180
                  ....*....|....*....|
gi 27369992   285 FVSPEKLESILEPNGLSVET 304
Cdd:pfam13489 143 LFSARSLKRLLEEAGFEVVS 162
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 150-252 2.87e-17

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 79.19  E-value: 2.87e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 150 KILDVGCGGGLLTEPL-GRLGASVVGIDPVAENIKIAQhhKSFDPVLDKRIQYKVCSLEEAVDESAECFDAVVASEVVEH 228
Cdd:COG0500  29 RVLDLGCGTGRNLLALaARFGGRVIGIDLSPEAIALAR--ARAAKAGLGNVEFLVADLAELDPLPAESFDLVVAFGVLHH 106

                        90       100
                ....*....|....*....|....*.
gi 27369992 229 VSHLEM--FIQCCYQVLKPGGSLFIT 252
Cdd:COG0500 107 LPPEEReaLLRELARALKPGGVLLLS 132
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
112-255 6.33e-17

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 77.73  E-value: 6.33e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 112 YGKFAPL---HSMNDLRVPFIRDNLLKTSASHHPGKPLSgmkILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHH 188
Cdd:COG4976  11 FDQYADSydaALVEDLGYEAPALLAEELLARLPPGPFGR---VLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREK 87

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369992 189 KSFDPVLdkriqykVCSLEEaVDESAECFDAVVASEVVEHVSHLEMFIQCCYQVLKPGGsLFITTVN 255
Cdd:COG4976  88 GVYDRLL-------VADLAD-LAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGG-LFIFSVE 145
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 148-253 6.89e-17

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 76.89  E-value: 6.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 148 GMKILDVGCGGGLLTEPL-GRLGASVVGIDPVAENIKIAQhHKSFDPVLDKRIQYKVCSLEEAVDEsaECFDAVVASEVV 226
Cdd:COG2230  52 GMRVLDIGCGWGGLALYLaRRYGVRVTGVTLSPEQLEYAR-ERAAEAGLADRVEVRLADYRDLPAD--GQFDAIVSIGMF 128

                        90       100
                ....*....|....*....|....*....
gi 27369992 227 EHVS--HLEMFIQCCYQVLKPGGSLFITT 253
Cdd:COG2230 129 EHVGpeNYPAYFAKVARLLKPGGRLLLHT 157
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 150-254 1.08e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 72.08  E-value: 1.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 150 KILDVGCGGGLLTEPLGRL-GASVVGIDPVAENIKIAQhhKSFDPVLDKRIQYKVCSLEEAVDESAECFDAVVASEVVEH 228
Cdd:cd02440   1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELAR--KAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHH 78

                        90       100
                ....*....|....*....|....*..
gi 27369992 229 VSHLEM-FIQCCYQVLKPGGSLFITTV 254
Cdd:cd02440  79 LVEDLArFLEEARRLLKPGGVLVLTLV 105
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 152-249 1.69e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 71.24  E-value: 1.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   152 LDVGCGGGLLTEPLGRL--GASVVGIDPVAENIKIA-QHHKSFDPVLDKRIQYKVCSLEEAVDESaecFDAVVASEVVEH 228
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAArERLAALGLLNAVRVELFQLDLGELDPGS---FDVVVASNVLHH 77

                          90       100
                  ....*....|....*....|.
gi 27369992   229 VSHLEMFIQCCYQVLKPGGSL 249
Cdd:pfam08242  78 LADPRAVLRNIRRLLKPGGVL 98
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
148-253 2.80e-15

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 70.62  E-value: 2.80e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 148 GMKILDVGCGGGLLTEPLGRL--GASVVGIDPVAENIKIAQHHKSfdpvldkRIQYKVCSLEEAvdESAECFDAVVASEV 225
Cdd:COG4106   2 PRRVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLP-------NVRFVVADLRDL--DPPEPFDLVVSNAA 72

                        90       100
                ....*....|....*....|....*...
gi 27369992 226 VEHVSHLEMFIQCCYQVLKPGGSLFITT 253
Cdd:COG4106  73 LHWLPDHAALLARLAAALAPGGVLAVQV 100
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 146-228 1.45e-10

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 60.62  E-value: 1.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  146 LSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVlDKRIQYKVCSLEEAvdesAECFDAVVASEV 225
Cdd:PRK07580  62 LTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGL-AGNITFEVGDLESL----LGRFDTVVCLDV 136


                 ...
gi 27369992  226 VEH 228
Cdd:PRK07580 137 LIH 139
PRK08317 PRK08317
hypothetical protein; Provisional
 148-251 2.23e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 60.34  E-value: 2.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  148 GMKILDVGCGGGLLTEPLGRL---GASVVGIDPVAENIKIAQHHKSFDPVldkRIQYkVCSLEEAVDESAECFDAVVASE 224
Cdd:PRK08317  20 GDRVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGLGP---NVEF-VRGDADGLPFPDGSFDAVRSDR 95

                         90       100
                 ....*....|....*....|....*..
gi 27369992  225 VVEHVSHLEMFIQCCYQVLKPGGSLFI 251
Cdd:PRK08317  96 VLQHLEDPARALAEIARVLRPGGRVVV 122
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 148-254 2.46e-10

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 60.42  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   148 GMKILDVGCG-GGLLTEPLGRLGASVVGIDPVAENIKIAQhhKSFDPV-LDKRIQYKVCSLEEaVDESaecFDAVVASEV 225
Cdd:pfam02353  62 GMTLLDIGCGwGGLMRRAAERYDVNVVGLTLSKNQYKLAR--KRVAAEgLARKVEVLLQDYRD-FDEP---FDRIVSVGM 135

                          90       100       110
                  ....*....|....*....|....*....|.
gi 27369992   226 VEHVSH--LEMFIQCCYQVLKPGGSLFITTV 254
Cdd:pfam02353 136 FEHVGHenYDTFFKKLYNLLPPGGLMLLHTI 166
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 147-255 7.37e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 57.04  E-value: 7.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   147 SGMKILDVGCGGGLLTEPLGRL---GASVVGIDPVAENIKIAQHHKSFDPVldKRIQYKVCSLEEA-VDESAECFDAVVA 222
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEElgpNAEVVGIDISEEAIEKARENAQKLGF--DNVEFEQGDIEELpELLEDDKFDVVIS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 27369992   223 SEVVEHVSHLEMFIQCCYQVLKPGGSLFITTVN 255
Cdd:pfam13847  81 NCVLNHIPDPDKVLQEILRVLKPGGRLIISDPD 113
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 145-315 8.83e-07

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 49.18  E-value: 8.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   145 PLSGMKILDVGCGGGLLTEPLGRLG---ASVVGIDPVAENIKIAQHHKSfdpvLDKRIQYKVCSLEEAVDESAEcFDAVV 221
Cdd:TIGR01934  37 VFKGQKVLDVACGTGDLAIELAKSApdrGKVTGVDFSSEMLEVAKKKSE----LPLNIEFIQADAEALPFEDNS-FDAVT 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   222 ASEVVEHVSHLEMFIQCCYQVLKPGGSLFI---TTVNKTQLS-----YALGIVfaEQIAGIVPKGTH--TW-----EKFV 286
Cdd:TIGR01934 112 IAFGLRNVTDIQKALREMYRVLKPGGRLVIlefSKPANALLKkfykfYLKNVL--PSIGGLISKNAEayTYlpesiRAFP 189

                         170       180
                  ....*....|....*....|....*....
gi 27369992   287 SPEKLESILEPNGLsvetvAGLVYNPFSG 315
Cdd:TIGR01934 190 SQEELAAMLKEAGF-----EEVRYRSLTF 213
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 147-260 1.01e-06

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 49.39  E-value: 1.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 147 SGMKILDVGCGGGLLTEPLGR-LGAS--VVGIDPVAENIKIAQHH-KSFDpvLDKRIQYKVCSLEEAVDESAecFDAVVA 222
Cdd:COG2519  91 PGARVLEAGTGSGALTLALARaVGPEgkVYSYERREDFAEIARKNlERFG--LPDNVELKLGDIREGIDEGD--VDAVFL 166

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 27369992 223 S-----EVVEHVshlemfiqccYQVLKPGGSL--FITTVNktQLS 260
Cdd:COG2519 167 DmpdpwEALEAV----------AKALKPGGVLvaYVPTVN--QVS 199
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 145-315 1.54e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 48.61  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  145 PLSGMKILDVGCGGGLLTEPLGRLG---ASVVGIDPVAENIKIAQhHKSFDPVLDKRIQYKVCSLEE---AvDESaecFD 218
Cdd:PRK00216  49 VRPGDKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAVGR-EKLRDLGLSGNVEFVQGDAEAlpfP-DNS---FD 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  219 AVVAS----EVVEHVSHL-EMfiqccYQVLKPGGSLFI---TTVNKTQLS-----YALGIV--FAEQIAG-------IVP 276
Cdd:PRK00216 124 AVTIAfglrNVPDIDKALrEM-----YRVLKPGGRLVIlefSKPTNPPLKkaydfYLFKVLplIGKLISKnaeaysyLAE 198

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 27369992  277 kgthTWEKFVSPEKLESILEPNGLSVETvaglvYNPFSG 315
Cdd:PRK00216 199 ----SIRAFPDQEELAAMLEEAGFERVR-----YRNLTG 228
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
216-253 2.12e-06

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 47.17  E-value: 2.12e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 27369992 216 CFDAVVASEVVEHVSHLEM--FIQCCYQVLKPGGSLFITT 253
Cdd:COG4627  46 SVDAIYSSHVLEHLDYEEAplALKECYRVLKPGGILRIVV 85
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 146-252 5.79e-06

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 47.26  E-value: 5.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   146 LSGMKILDVGCGGGLLTEPLGRLGA-SVVG--IDPVAenIKIAQHHKSFDPVlDKRIQYKVcsLEEAVDESaecFDAVVA 222
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIAALKLGAkKVVGvdIDPVA--VRAAKENAELNGV-EARLEVYL--PGDLPKEK---ADVVVA 231

                          90       100       110
                  ....*....|....*....|....*....|...
gi 27369992   223 ---SEVvehvshLEMFIQCCYQVLKPGGsLFIT 252
Cdd:pfam06325 232 nilADP------LIELAPDIYALVKPGG-YLIL 257
PRK14968 PRK14968
putative methyltransferase; Provisional
 148-258 1.70e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 44.89  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  148 GMKILDVGCGGGLLTEPLGRLGASVVGID--PVAenIKIAQHHKSFDPVLDKRIQYKVCSLEEAVDesAECFDAVV---- 221
Cdd:PRK14968  24 GDRVLEVGTGSGIVAIVAAKNGKKVVGVDinPYA--VECAKCNAKLNNIRNNGVEVIRSDLFEPFR--GDKFDVILfnpp 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 27369992  222 ---ASEVVEHVSHLEM--------------FIQCCYQVLKPGGSLFI-----TTVNKTQ 258
Cdd:PRK14968 100 ylpTEEEEEWDDWLNYalsggkdgrevidrFLDEVGRYLKPGGRILLlqsslTGEDEVL 158
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 150-253 2.13e-05

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 45.36  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   150 KILDVGCGGGLLTEPLGRLG--ASVVGIDPVAENIKIAQHHKSfdpvldKRIQYkVCSLEEAVDESAECFDAVVASEVVE 227
Cdd:TIGR02072  37 SVLDIGCGTGYLTRALLKRFpqAEFIALDISAGMLAQAKTKLS------ENVQF-ICGDAEKLPLEDSSFDLIVSNLALQ 109

                          90       100
                  ....*....|....*....|....*.
gi 27369992   228 HVSHLEMFIQCCYQVLKPGGSLFITT 253
Cdd:TIGR02072 110 WCDDLSQALSELARVLKPGGLLAFST 135
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
134-273 3.61e-05

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 44.57  E-value: 3.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  134 LKTSASHHPGKPLSgmkILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDKrIQYKVCSLEEAVDES 213
Cdd:PRK11036  34 LDRLLAELPPRPLR---VLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQAAEAKGVSDN-MQFIHCAAQDIAQHL 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  214 AECFDAVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFITTVNktqlsyALGIVFAEQIAG 273
Cdd:PRK11036 110 ETPVDLILFHAVLEWVADPKSVLQTLWSVLRPGGALSLMFYN------ANGLLMHNMVAG 163
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
140-306 8.62e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 43.60  E-value: 8.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  140 HHP----------GKPLSGMKILDVGCGGGLLTEPLGRLGA-SVVG--IDPVAenIKIAQHHksfdpvldkrIQYKVCSL 206
Cdd:PRK00517 102 THPttrlclealeKLVLPGKTVLDVGCGSGILAIAAAKLGAkKVLAvdIDPQA--VEAAREN----------AELNGVEL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  207 EEAVDESAECFDAVVA---SEVvehvshLEMFIQCCYQVLKPGGSLFittvnktqLSyalGIVfAEQIagivpkgthtwe 283
Cdd:PRK00517 170 NVYLPQGDLKADVIVAnilANP------LLELAPDLARLLKPGGRLI--------LS---GIL-EEQA------------ 219

                        170       180
                 ....*....|....*....|...
gi 27369992  284 kfvspEKLESILEPNGLSVETVA 306
Cdd:PRK00517 220 -----DEVLEAYEEAGFTLDEVL 237
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
145-306 1.04e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 43.62  E-value: 1.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 145 PLSGMKILDVGCGGGLLTepLG--RLGAS-VVG--IDPVA-----ENIKIAQhhksfdpvLDKRIQykvcsLEEAVDESA 214
Cdd:COG2264 146 LKPGKTVLDVGCGSGILA--IAaaKLGAKrVLAvdIDPVAveaarENAELNG--------VEDRIE-----VVLGDLLED 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992 215 ECFDAVVA---SEVvehvshLEMFIQCCYQVLKPGGSLFittvnktqLSyalGIVfAEQIagivpkgthtwekfvspEKL 291
Cdd:COG2264 211 GPYDLVVAnilANP------LIELAPDLAALLKPGGYLI--------LS---GIL-EEQA-----------------DEV 255

                       170
                ....*....|....*
gi 27369992 292 ESILEPNGLSVETVA 306
Cdd:COG2264 256 LAAYEAAGFELVERR 270
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 144-252 2.06e-04

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 43.20  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  144 KPlsGMKILDVGCG-GG---LLTEplgRLGASVVGIDPVAENIKIAqhhksfdpvLDKRIQYKvCSLEEAVdesAEC--- 216
Cdd:PLN02336 265 KP--GQKVLDVGCGiGGgdfYMAE---NFDVHVVGIDLSVNMISFA---------LERAIGRK-CSVEFEV---ADCtkk 326

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 27369992  217 ------FDAVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFIT 252
Cdd:PLN02336 327 typdnsFDVIYSRDTILHIQDKPALFRSFFKWLKPGGKVLIS 368
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
145-253 2.10e-04

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 42.92  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  145 PLSGMKILDVGCGGGL-LTEPLGRLGASVVGIDPVaenikiAQHHKSFDPV-----LDKRIQYKVCSLEEAvdESAECFD 218
Cdd:PRK15068 120 PLKGRTVLDVGCGNGYhMWRMLGAGAKLVVGIDPS------QLFLCQFEAVrkllgNDQRAHLLPLGIEQL--PALKAFD 191

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 27369992  219 AVVASEVVEH-VSHLEMFIQcCYQVLKPGGSLFITT 253
Cdd:PRK15068 192 TVFSMGVLYHrRSPLDHLKQ-LKDQLVPGGELVLET 226
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 150-252 3.78e-04

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 41.88  E-value: 3.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  150 KILDVGCG-GGLLTEPLGRLGASVVGIDPVAENIKIAQhhksfdpvldKRIQYKVCSLEEAVD----ESAEC-FDAVVAS 223
Cdd:PTZ00098  55 KVLDIGSGlGGGCKYINEKYGAHVHGVDICEKMVNIAK----------LRNSDKNKIEFEANDilkkDFPENtFDMIYSR 124

                         90       100       110
                 ....*....|....*....|....*....|.
gi 27369992  224 EVVEHVSHLE--MFIQCCYQVLKPGGSLFIT 252
Cdd:PTZ00098 125 DAILHLSYADkkKLFEKCYKWLKPNGILLIT 155
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
145-249 5.78e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 40.89  E-value: 5.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   145 PLSGMKILDVGCGGGLLTEPLGRL-GAS--VVGIDPVAENIKIAQhhKSFDPVLDKRIQYkVCSLEEAVDESAECFDAVV 221
Cdd:pfam01209  40 VKRGNKFLDVAGGTGDWTFGLSDSaGSSgkVVGLDINENMLKEGE--KKAKEEGKYNIEF-LQGNAEELPFEDDSFDIVT 116

                          90       100
                  ....*....|....*....|....*...
gi 27369992   222 ASEVVEHVSHLEMFIQCCYQVLKPGGSL 249
Cdd:pfam01209 117 ISFGLRNFPDYLKVLKEAFRVLKPGGRV 144
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 150-223 8.71e-04

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 39.62  E-value: 8.71e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369992   150 KILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDkRIQYKVCSLEEAVD---ESAECFDAVVAS 223
Cdd:pfam09445   3 RILDVFCGGGGNTIQFANVFDSVISIDINLEHLACAQHNAEVYGVSD-RIWLIHGDWFELLAklkFEKIKYDCVFAS 78
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 145-253 1.49e-03

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 40.08  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992   145 PLSGMKILDVGCGGGL-LTEPLGRLGASVVGIDPVaenikiAQHHKSFDPV-----LDKRIQYKVCSLEEAvdESAECFD 218
Cdd:pfam08003 113 PLKGRTILDVGCGNGYhMWRMLGEGAAMVVGIDPS------ELFLCQFEAVrkllgNDQRAHLLPLGIEQL--PALAAFD 184

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 27369992   219 AVVASEVVEH-VSHLEMFIQCCYQvLKPGGSLFITT 253
Cdd:pfam08003 185 TVFSMGVLYHrRSPLDHLLQLKDQ-LVKGGELVLET 219
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
148-260 1.52e-03

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 40.22  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  148 GMKILDVGCG-GGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVlDKRIQ-YKvcsleeAVDESaecFDAVVASEV 225
Cdd:PRK11705 168 GMRVLDIGCGwGGLARYAAEHYGVSVVGVTISAEQQKLAQERCAGLPV-EIRLQdYR------DLNGQ---FDRIVSVGM 237

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 27369992  226 VEHVSH--LEMFIQCCYQVLKPGGSLFITTV--NKTQLS 260
Cdd:PRK11705 238 FEHVGPknYRTYFEVVRRCLKPDGLFLLHTIgsNKTDTN 276
PRK06202 PRK06202
hypothetical protein; Provisional
 142-230 1.83e-03

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 39.21  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  142 PGKPLSgmkILDVGCGGGLLTEPLGRLGA------SVVGIDPVAENIKIAQHHksfdpVLDKRIQYKVCSLEEAVDESaE 215
Cdd:PRK06202  58 ADRPLT---LLDIGCGGGDLAIDLARWARrdglrlEVTAIDPDPRAVAFARAN-----PRRPGVTFRQAVSDELVAEG-E 128

                         90
                 ....*....|....*
gi 27369992  216 CFDAVVASEVVEHVS 230
Cdd:PRK06202 129 RFDVVTSNHFLHHLD 143
PLN02244 PLN02244
tocopherol O-methyltransferase
 109-253 2.38e-03

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 39.34  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  109 WDEY---GKFAPLHSMNDLRVPFIR--DNLLKTSAShhPGKPLSGMK-ILDVGCGGGLLTEPLGR-LGASVVGI--DPV- 178
Cdd:PLN02244  76 WGEHmhhGYYDPGASRGDHRQAQIRmiEESLAWAGV--PDDDEKRPKrIVDVGCGIGGSSRYLARkYGANVKGItlSPVq 153

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27369992  179 ---AENIKIAQHhksfdpvLDKRIQYKVC-SLEEAVDESaeCFDAVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFITT 253
Cdd:PLN02244 154 aarANALAAAQG-------LSDKVSFQVAdALNQPFEDG--QFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIIIVT 223
PRK06922 PRK06922
class I SAM-dependent methyltransferase;
146-251 3.08e-03

class I SAM-dependent methyltransferase;


Pssm-ID: 180751 [Multi-domain]  Cd Length: 677  Bit Score: 39.47  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369992  146 LSGMKILDVGCGGG----LLTEPLGRlgASVVGIDpVAENI------KIAQHHKSFDPvldkrIQYKVCSLEEAVDEsaE 215
Cdd:PRK06922 417 IKGDTIVDVGAGGGvmldMIEEETED--KRIYGID-ISENVidtlkkKKQNEGRSWNV-----IKGDAINLSSSFEK--E 486

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 27369992  216 CFDAVVASEVV-EHVSHLEM------------FIQCCYQVLKPGGSLFI 251
Cdd:PRK06922 487 SVDTIVYSSILhELFSYIEYegkkfnhevikkGLQSAYEVLKPGGRIII 535
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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