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    Cstf3 cleavage stimulation factor, 3' pre-RNA, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 228410, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cstf3provided by MGI
    Official Full Name
    cleavage stimulation factor, 3' pre-RNA, subunit 3provided by MGI
    Primary source
    MGI:MGI:1351825
    See related
    Ensembl:ENSMUSG00000027176 AllianceGenome:MGI:1351825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CstF-77; 4732468G05Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in RNA 3'-end processing. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including ganglia; liver; submandibular gland primordium; thymus primordium; and vibrissa. Orthologous to human CSTF3 (cleavage stimulation factor subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 8.3), CNS E14 (RPKM 7.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E2; 2 54.84 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (104420829..104495770)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (104590484..104665425)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9199 Neighboring gene pluripotency associated transcript 14 Neighboring gene predicted gene, 22439 Neighboring gene STARR-positive B cell enhancer ABC_E2044 Neighboring gene t-complex 11 like 1 Neighboring gene predicted gene 6306 Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1, retrogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors. Bai Y, et al. Mol Cell, 2007 Mar 23. PMID 17386263
    2. Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance. Kleinjan DA, et al. Mamm Genome, 2002 Feb. PMID 11889558
    3. A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. Gawin B, et al. Genome Res, 1999 Nov. PMID 10568747, Free PMC Article
    4. Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein. Piazzi M, et al. Mol Cell Proteomics, 2013 Aug. PMID 23665500, Free PMC Article
    5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of the HAT (half a TPR) domain of murine CstF-77, as well as its C-terminal subdomain.
      Title: Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6373

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage stimulating factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cleavage stimulation factor subunit 3
    Names
    CF-1 77 kDa subunit
    CSTF 77 kDa subunit
    cleavage stimulation factor 77 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037326.2 → NP_001032403.1  cleavage stimulation factor subunit 3 isoform 3

      See identical proteins and their annotated locations for NP_001032403.1

      Status: VALIDATED

      Source sequence(s)
      AL844603
      Related
      ENSMUST00000137961.2

    2. NM_145529.3 → NP_663504.1  cleavage stimulation factor subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_663504.1

      Status: VALIDATED

      Source sequence(s)
      AL844603
      Consensus CDS
      CCDS16490.1
      UniProtKB/Swiss-Prot
      Q99LI7
      UniProtKB/TrEMBL
      Q3TXN6
      Related
      ENSMUSP00000028599.8, ENSMUST00000028599.8
      Conserved Domains (3) summary
      COG5107
      Location:2 → 532
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      sd00006
      Location:31 → 60
      TPR; TPR repeat [structural motif]
      pfam05843
      Location:375 → 649
      Suf; Suppressor of forked protein (Suf)

    3. NM_177253.4 → NP_796227.1  cleavage stimulation factor subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_796227.1

      Status: VALIDATED

      Source sequence(s)
      AL844603
      UniProtKB/TrEMBL
      Q8CE71
      Related
      ENSMUST00000122900.2
      Conserved Domains (2) summary
      smart00386
      Location:45 → 77
      HAT; HAT (Half-A-TPR) repeats
      cl19115
      Location:63 → 94
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      104420829..104495770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LI7.1 GenPept UniProtKB/Swiss-Prot:Q99LI7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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