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    Larp4b La ribonucleoprotein 4B [ Mus musculus (house mouse) ]

    Gene ID: 217980, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Larp4bprovided by MGI
    Official Full Name
    La ribonucleoprotein 4Bprovided by MGI
    Primary source
    MGI:MGI:106330
    See related
    Ensembl:ENSMUSG00000033499 AllianceGenome:MGI:106330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Larp5; D13Wsu64e; A630096F19; A130023E24Rik
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in positive regulation of 3'-UTR-mediated mRNA stabilization and positive regulation of translation. Predicted to act upstream of or within regulation of translation. Predicted to be located in nucleolus and polysomal ribosome. Predicted to be active in cytoplasmic stress granule and cytosol. Is expressed in embryo; extraembryonic component; and vertebral axis musculature. Orthologous to human LARP4B (La ribonucleoprotein 4B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.9), liver E14 (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A1; 13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (9143643..9224487)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (9093653..9174451)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene GTP binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E2396 Neighboring gene predicted gene, 36264 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33610 Neighboring gene STARR-seq mESC enhancer starr_33614 Neighboring gene STARR-seq mESC enhancer starr_33615 Neighboring gene predicted gene 8784 Neighboring gene predicted gene, 46391

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Gehman LT, et al. Genes Dev, 2012 Mar 1. PMID 22357600, Free PMC Article
    2. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article
    3. Identification of differential protein interactors of lamin A and progerin. Kubben N, et al. Nucleus, 2010 Nov-Dec. PMID 21327095, Free PMC Article
    4. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
    5. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC78318

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    la-related protein 4B
    Names
    La ribonucleoprotein domain family, member 4B
    La ribonucleoprotein domain family, member 5
    la ribonucleoprotein domain family member 5
    la-related protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311117.1 → NP_001298046.1  la-related protein 4B isoform 2

      See identical proteins and their annotated locations for NP_001298046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC125484, AC131743, BC059218, BU056450, CF540574, CF950134
      Consensus CDS
      CCDS79162.1
      UniProtKB/Swiss-Prot
      Q6A0A2
      Related
      ENSMUSP00000089437.4, ENSMUST00000091829.4
      Conserved Domains (2) summary
      cd08036
      Location:159 → 233
      LARP_5; La RNA-binding domain of La-related protein 5
      cl17169
      Location:238 → 314
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_172585.3 → NP_766173.1  la-related protein 4B isoform 1

      See identical proteins and their annotated locations for NP_766173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125484, AC131743, BC059218, BU056450, CF540574, CF950134
      Consensus CDS
      CCDS36588.1
      UniProtKB/Swiss-Prot
      Q3TUH7, Q6A0A2, Q6AZA8, Q8BJP3, Q8BY17
      Related
      ENSMUSP00000140993.2, ENSMUST00000188211.8
      Conserved Domains (2) summary
      cd08036
      Location:159 → 233
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:238 → 314
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      9143643..9224487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516476.4 → XP_006516539.1  la-related protein 4B isoform X3

      See identical proteins and their annotated locations for XP_006516539.1

      UniProtKB/Swiss-Prot
      Q3TUH7, Q6A0A2, Q6AZA8, Q8BJP3, Q8BY17
      Conserved Domains (2) summary
      cd08036
      Location:159 → 233
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:238 → 314
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

    2. XM_036157976.1 → XP_036013869.1  la-related protein 4B isoform X3

      UniProtKB/Swiss-Prot
      Q3TUH7, Q6A0A2, Q6AZA8, Q8BJP3, Q8BY17
      Conserved Domains (2) summary
      cd08036
      Location:159 → 233
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:238 → 314
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

    3. XM_011244254.4 → XP_011242556.1  la-related protein 4B isoform X2

      Conserved Domains (2) summary
      cd08036
      Location:1141 → 1215
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:1220 → 1296
      RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)

    4. XM_011244253.4 → XP_011242555.1  la-related protein 4B isoform X1

      Conserved Domains (2) summary
      cd08036
      Location:1141 → 1215
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:1220 → 1296
      RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002776.1: Suppressed sequence

      Description
      NM_001002776.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A0A2.2 GenPept UniProtKB/Swiss-Prot:Q6A0A2

    Gene LinkOut

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