Conserved Protein Domain Family
RRM_LARP5
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cd12706: RRM_LARP5 
RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)
This subgroup corresponds to the RRM of LARP5, a cytosolic protein that co-sediments with polysomes and accumulates upon stress induction in cellular stress granules. It can interact with the cytosolic poly(A) binding protein 1 (PABPC1) and the receptor for activated C Kinase (RACK1), a component of the 40S ribosomal subunit. LARP5 may function as a stimulatory factor of translation through bridging mRNA factors of the 3' end with initiating ribosomes. Like other La-related proteins (LARPs) family members, LARP5 contains a La motif (LAM) and an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).
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Statistics
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PSSM-Id: 410105
Aligned: 5 rows
Threshold Bit Score: 174.085
Created: 10-Feb-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q92615        236 CIVILREISESTPVEEVEALFKgDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKA 312  human
NP_001123740  224 CIVILREVPESTPVEEVEALFKgENLPKFINCEFAYNDNWFITFESEADAQQAYKYLREEVKTFQGKPIKARIKAKA 300  western clawed frog
NP_001071030  224 CIVILREIPEATPLEEVEALFKsDNLPKFINCEFAYNDNWFITFESEADAQLAYQYLREEVKTFQGKPIKARIKAKA 300  zebrafish
XP_014350885  228 RIVILREVPESTPIEEVEALFKgGNLPKFVNCEFAYNDNWFITFESEADAQQAYKYLREEVKTFQGKPIKARIKAKA 304  coelacanth
XP_007899385 1060 CIVILREVPESTPIEEVEALFKgENFPKFMSCEFAYNDNWFITFESEADAQQAYRYLREEVKTFQGRPIKARIKAKP 1136 elephant shark
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