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    Tfec transcription factor EC [ Mus musculus (house mouse) ]

    Gene ID: 21426, updated on 9-May-2024

    Summary

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    Official Symbol
    Tfecprovided by MGI
    Official Full Name
    transcription factor ECprovided by MGI
    Primary source
    MGI:MGI:1333760
    See related
    Ensembl:ENSMUSG00000029553 AllianceGenome:MGI:1333760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcfec; bHLHe34
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to heat. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; esophagus; intestine; male reproductive gland or organ; and urinary system. Orthologous to human TFEC (transcription factor EC). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 1.9), liver E18 (RPKM 1.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A2; 6 7.61 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (16830926..16898463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (16830927..16898464, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15244 Neighboring gene predicted gene, 36503 Neighboring gene STARR-seq mESC enhancer starr_15245 Neighboring gene STARR-seq mESC enhancer starr_15246 Neighboring gene STARR-seq mESC enhancer starr_15247 Neighboring gene predicted gene, 36669 Neighboring gene STARR-seq mESC enhancer starr_15248 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:17015482-17015727 Neighboring gene predicted gene 15473 Neighboring gene testin LIM domain protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. Rehli M, et al. J Immunol, 1999 Feb 1. PMID 9973413
    2. Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. Rehli M, et al. J Immunol, 2005 Jun 1. PMID 15908341
    3. Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor α positive feedback loop in M2 macrophages. Wang Y, et al. J Allergy Clin Immunol, 2017 Dec. PMID 28238747
    4. TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation. Zhao GQ, et al. Mol Cell Biol, 1993 Aug. PMID 8336698, Free PMC Article
    5. Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Rehli M, et al. Genomics, 1999 Feb 15. PMID 10036191

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tfec transcribes IL-4 receptor alpha expression to promote M2 programming in macrophages
      Title: Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor α positive feedback loop in M2 macrophages.
    2. Data indicate that FOS, SPI1, KLF10, TFEC, and PRDM16 show robust transcriptional cross-regulation and are often associated with osteoclastogenesis.
      Title: Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity.
    3. Transcription factor EC, along with several other transcription factors, is a Stat6-dependent target of IL-4.
      Title: Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107474

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor EC
    Names
    TFE-C
    mTFEC

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031198.3 → NP_112475.1  transcription factor EC

      See identical proteins and their annotated locations for NP_112475.1

      Status: VALIDATED

      Source sequence(s)
      AC102663, AK137141
      Consensus CDS
      CCDS19920.1
      UniProtKB/Swiss-Prot
      Q3TWR7, Q9WTW4
      Related
      ENSMUSP00000031533.8, ENSMUST00000031533.11
      Conserved Domains (3) summary
      cd00083
      Location:108 → 168
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam11851
      Location:196 → 300
      DUF3371; Domain of unknown function (DUF3371)
      cl21462
      Location:164 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      16830926..16898463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241053.3 → XP_011239355.1  transcription factor EC isoform X2

      Conserved Domains (2) summary
      pfam11851
      Location:213 → 317
      DUF3371; Domain of unknown function (DUF3371)
      cl00081
      Location:148 → 219
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    2. XM_006505035.5 → XP_006505098.1  transcription factor EC isoform X1

      Conserved Domains (2) summary
      pfam11851
      Location:232 → 336
      DUF3371; Domain of unknown function (DUF3371)
      cd18926
      Location:135 → 238
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

    3. XM_017321504.2 → XP_017176993.1  transcription factor EC isoform X4

      Conserved Domains (2) summary
      pfam11851
      Location:97 → 201
      DUF3371; Domain of unknown function (DUF3371)
      cl00081
      Location:32 → 103
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    4. XM_006505036.4 → XP_006505099.1  transcription factor EC isoform X3

      Conserved Domains (2) summary
      pfam11851
      Location:158 → 262
      DUF3371; Domain of unknown function (DUF3371)
      cd18926
      Location:61 → 164
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

    5. XM_006505037.4 → XP_006505100.1  transcription factor EC isoform X4

      Conserved Domains (2) summary
      pfam11851
      Location:97 → 201
      DUF3371; Domain of unknown function (DUF3371)
      cl00081
      Location:32 → 103
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTW4.1 GenPept UniProtKB/Swiss-Prot:Q9WTW4

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