4ATI


Conserved Protein Domain Family
bHLHzip_MITF
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cd18926: bHLHzip_MITF 
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basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).
Links
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Statistics
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PSSM-Id: 381496
Aligned: 7 rows
Threshold Bit Score: 154.857
Created: 18-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingdimer interface
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences.
  • Structure:4ATI; Mus musculus Mitf binds DNA, contacts at 4A.
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        ## ##  ##   #                    ##                             
4ATI_A        15 ESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQK 94  house mouse
NP_990360    242 ESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRTKELENRQK 321 chicken
O75030       300 ESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQK 379 human
XP_007893406 279 EAEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRRLQKEQHRAKELESRQK 358 elephant shark
Q90XP4       284 EVEVRALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQHRTKELENRQK 363 zebrafish
XP_005995278 264 ETEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQKEQQRAKELENRQK 343 coelacanth
NP_001165646 260 ETEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRSKEVENKQK 339 African clawed ...

Feature 1                                
4ATI_A        95 KLEHANRHLLLRVQELEMQARAHG 118 house mouse
NP_990360    322 KLEHANRHLLLRIQELEMQARAHG 345 chicken
O75030       380 KLEHANRHLLLRIQELEMQARAHG 403 human
XP_007893406 359 KLEHANRHLLLRIQELEMQARAHG 382 elephant shark
Q90XP4       364 KLEHTNRNLLLRIQELEIRARAHG 387 zebrafish
XP_005995278 344 KLENANRHLLLRIQELEMQARAHG 367 coelacanth
NP_001165646 340 KLEHANRHLLLRIQELEMQARAHG 363 African clawed frog

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