U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ssb small RNA binding exonuclease protection factor La [ Mus musculus (house mouse) ]

    Gene ID: 20823, updated on 2-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ssbprovided by MGI
    Official Full Name
    small RNA binding exonuclease protection factor Laprovided by MGI
    Primary source
    MGI:MGI:98423
    See related
    Ensembl:ENSMUSG00000068882 AllianceGenome:MGI:98423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SS-B
    Summary
    Enables RNA binding activity. Predicted to be involved in several processes, including IRES-dependent viral translational initiation; RNA metabolic process; and protein localization to cytoplasmic stress granule. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; sensory organ; and spleen. Orthologous to human SSB (small RNA binding exonuclease protection factor La). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 93.7), liver E14 (RPKM 50.9) and 11 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    2 C2; 2 40.95 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69691963..69702185)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69861562..69871846)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39841 Neighboring gene STARR-positive B cell enhancer mm9_chr2:69698414-69698714 Neighboring gene STARR-positive B cell enhancer ABC_E4462 Neighboring gene kelch-like 23 Neighboring gene STARR-positive B cell enhancer ABC_E11134 Neighboring gene STARR-seq mESC enhancer starr_04746 Neighboring gene STARR-positive B cell enhancer ABC_E508 Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene STARR-seq mESC enhancer starr_04748 Neighboring gene STARR-positive B cell enhancer ABC_E9515 Neighboring gene STARR-seq mESC enhancer starr_04749 Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene STARR-seq mESC enhancer starr_04750 Neighboring gene STARR-positive B cell enhancer ABC_E4463 Neighboring gene myosin IIIB Neighboring gene STARR-seq mESC enhancer starr_04751 Neighboring gene STARR-seq mESC enhancer starr_04752 Neighboring gene STARR-seq mESC enhancer starr_04756 Neighboring gene STARR-seq mESC enhancer starr_04757

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation. Ha N, et al. Nucleic Acids Res, 2021 Nov 18. PMID 34723322, Free PMC Article
    2. La Deletion from Mouse Brain Alters Pre-tRNA Metabolism and Accumulation of Pre-5.8S rRNA, with Neuron Death and Reactive Astrocytosis. Blewett NH, et al. Mol Cell Biol, 2017 May 15. PMID 28223366, Free PMC Article
    3. T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQB1*0201. Dudek NL, et al. Arthritis Rheum, 2007 Oct. PMID 17907193
    4. In vivo targeting of dead tumor cells in a murine tumor model using a monoclonal antibody specific for the La autoantigen. Al-Ejeh F, et al. Clin Cancer Res, 2007 Sep 15. PMID 17875784
    5. Characterization of the mouse autoantigen La (SS-B). Identification of conserved RNA-binding motifs, a putative ATP binding site and reactivity of recombinant protein with poly(U) and human autoantibodies. Topfer F, et al. J Immunol, 1993 Apr 1. PMID 8454877

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation.
      Title: The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation.
    2. La deletion is associated with Neuron Death and Reactive Astrocytosis.
      Title: La Deletion from Mouse Brain Alters Pre-tRNA Metabolism and Accumulation of Pre-5.8S rRNA, with Neuron Death and Reactive Astrocytosis.
    3. Data indicate that La antigen (Sjogren's syndrome antigen B) is essential in different cell types and required for normal development of various tissue types.
      Title: Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss.
    4. Overexpression of mouse or human La enhanced M-MuLV particle release in the absence of glycosylated gag.
      Title: The cellular protein La functions in enhancement of virus release through lipid rafts facilitated by murine leukemia virus glycosylated Gag.
    5. La appears to be an important contributor to Akt-mediated translational regulation of these transcripts in murine glial cells.
      Title: Akt phosphorylation of La regulates specific mRNA translation in glial progenitors.
    6. Overexpression of La autoantigen is associated with lymphoma
      Title: In vivo targeting of dead tumor cells in a murine tumor model using a monoclonal antibody specific for the La autoantigen.
    7. truncation of La alters the immunodominance hierarchy of T cell responsiveness to hLa and may be a factor in the initiation or maintenance of anti-La autoimmunity.
      Title: T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQB1*0201.
    8. Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity.
      Title: Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity.
    9. Blastocysts derived from La+/- intercrosses yielded 38 La+/+ and La+/- embryonic stem (ES) cell lines but no La-/- ES cell lines, suggesting that La contributes a critical function toward the establishment or survival of ES cells.
      Title: The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC118101

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear histone mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lupus La protein homolog
    Names
    La protein
    Lupus LA protein homolog (LA ribonucleoprotein) (LA autoantigen homolog)
    Sjogren syndrome antigen B
    autoantigen La
    la autoantigen homolog
    la ribonucleoprotein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110145.2 → NP_001103615.1  lupus La protein homolog isoform a

      See identical proteins and their annotated locations for NP_001103615.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AL845261, AL929249, BX322634
      Consensus CDS
      CCDS16101.1
      UniProtKB/Swiss-Prot
      P32067
      UniProtKB/TrEMBL
      Q3TG93, Q564E6, Q8BTU4
      Related
      ENSMUSP00000088365.5, ENSMUST00000090852.11
      Conserved Domains (3) summary
      cd08028
      Location:10 → 91
      LARP_3; La RNA-binding domain of La-related protein 3
      cd12291
      Location:112 → 183
      RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
      pfam08777
      Location:230 → 333
      RRM_3; RNA binding motif

    2. NM_001355265.2 → NP_001342194.1  lupus La protein homolog isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3, 8, and 9 all encode the same isoform (b).
      Source sequence(s)
      AL845261, AL929249, BX322634
      UniProtKB/TrEMBL
      Q3TG93, Q8BTU4
      Conserved Domains (3) summary
      cd08028
      Location:10 → 91
      LARP_3; La RNA-binding domain of La-related protein 3
      cd12291
      Location:112 → 183
      RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
      cd12541
      Location:230 → 306
      RRM2_La; RNA recognition motif 2 in La autoantigen (La or LARP3) and similar proteins

    3. NM_001421043.1 → NP_001407972.1  lupus La protein homolog isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634
      UniProtKB/Swiss-Prot
      P32067
      UniProtKB/TrEMBL
      Q564E6

    4. NM_001421044.1 → NP_001407973.1  lupus La protein homolog isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634
      UniProtKB/Swiss-Prot
      P32067
      UniProtKB/TrEMBL
      Q564E6

    5. NM_001421045.1 → NP_001407974.1  lupus La protein homolog isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634
      UniProtKB/Swiss-Prot
      P32067
      UniProtKB/TrEMBL
      Q564E6

    6. NM_001421046.1 → NP_001407975.1  lupus La protein homolog isoform b

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634

    7. NM_001421049.1 → NP_001407978.1  lupus La protein homolog isoform b

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634

    8. NM_001421050.1 → NP_001407979.1  lupus La protein homolog isoform c

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634

    9. NM_001421052.1 → NP_001407981.1  lupus La protein homolog isoform c

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634

    10. NM_001421053.1 → NP_001407982.1  lupus La protein homolog isoform c

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634

    11. NM_001421054.1 → NP_001407983.1  lupus La protein homolog isoform d

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634

    12. NM_009278.5 → NP_033304.1  lupus La protein homolog isoform a

      See identical proteins and their annotated locations for NP_033304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AL845261, AL929249, BX322634
      Consensus CDS
      CCDS16101.1
      UniProtKB/Swiss-Prot
      P32067
      UniProtKB/TrEMBL
      Q3TG93, Q564E6, Q8BTU4
      Related
      ENSMUSP00000130313.2, ENSMUST00000166411.8
      Conserved Domains (3) summary
      cd08028
      Location:10 → 91
      LARP_3; La RNA-binding domain of La-related protein 3
      cd12291
      Location:112 → 183
      RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
      pfam08777
      Location:230 → 333
      RRM_3; RNA binding motif

    RNA

    1. NR_149321.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL845261, AL929249, BX322634

    2. NR_185233.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634

    3. NR_185234.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845261, AL929249, BX322634

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69691963..69702185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32067.1 GenPept UniProtKB/Swiss-Prot:P32067

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous