St6gal1 beta galactoside alpha 2,6 sialyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: St6gal1provided by MGI
Official Full Name: beta galactoside alpha 2,6 sialyltransferase 1provided by MGI
Primary source: MGI:MGI:108470
See related: Ensembl:ENSMUSG00000022885 AllianceGenome:MGI:108470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Siat1; St6gal; St6galI; St6Gal-I
Summary: This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Nov 2011]
Expression: Broad expression in genital fat pad adult (RPKM 48.2), liver E18 (RPKM 29.4) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B1; 16 14.03 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (23043478..23179100)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (23224729..23360350)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.
Title: ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.
CCCTC-binding factor: the specific transcription factor of beta-galactoside alpha-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.
Title: CCCTC-binding factor: the specific transcription factor of β-galactoside α-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.
Platelet-localized ST6Gal1 does not impact IgG sialylation.
Title: Platelet-localized ST6Gal1 does not impact IgG sialylation.
alpha2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth.
Title: α2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth.
ST6Gal1 in plasma is dispensable for IgG sialylation.
Title: ST6Gal1 in plasma is dispensable for IgG sialylation.
Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
Title: Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
Title: Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage.
Title: The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage.
Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells.
Title: Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells.
Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase.
Title: Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

Siat1 (e-PCR), detects polymorphism
- UniSTS:261912

AW742324 (e-PCR)
- UniSTS:209192

BB163080 (e-PCR)
- UniSTS:186063

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-galactoside alpha-2,6-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-galactoside alpha-2,6-sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-galactoside alpha-2,6-sialyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables beta-galactoside alpha-2,6-sialyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sialyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylneuraminate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mononuclear cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation via asparagine	IDA Inferred from Direct Assay more info	PubMed
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in sialylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sialylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi medial cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi trans cisterna	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-galactoside alpha-2,6-sialyltransferase 1

Names: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; alpha 2,6-ST 1

NP_001239434.1

EC 2.4.3.1

NP_001239435.1

EC 2.4.3.1

NP_001413535.1

EC 2.4.3.1

NP_666045.1

EC 2.4.3.1

XP_006521938.1

EC 2.4.3.1

XP_006521939.1

EC 2.4.3.1

XP_011244150.1

EC 2.4.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252505.1 → NP_001239434.1 beta-galactoside alpha-2,6-sialyltransferase 1

See identical proteins and their annotated locations for NP_001239434.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK034768, BY254258, CD349601, CF741963, CJ238175, CN458528

Consensus CDS

CCDS28077.1

UniProtKB/Swiss-Prot

Q64685, Q8K1L1

Related

ENSMUSP00000136206.2, ENSMUST00000178797.8

Conserved Domains (1) summary

pfam00777
Location:174 → 379

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
NM_001252506.1 → NP_001239435.1 beta-galactoside alpha-2,6-sialyltransferase 1

See identical proteins and their annotated locations for NP_001239435.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI787561, AK034768, BY134193, CF741963, CJ238175, CN458528

Consensus CDS

CCDS28077.1

UniProtKB/Swiss-Prot

Q64685, Q8K1L1

Related

ENSMUSP00000110992.2, ENSMUST00000115335.2

Conserved Domains (1) summary

pfam00777
Location:174 → 379

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
NM_001426606.1 → NP_001413535.1 beta-galactoside alpha-2,6-sialyltransferase 1

Status: REVIEWED

Source sequence(s)

AC163612

UniProtKB/Swiss-Prot

Q64685, Q8K1L1
NM_145933.4 → NP_666045.1 beta-galactoside alpha-2,6-sialyltransferase 1

See identical proteins and their annotated locations for NP_666045.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

BC092222, CF898349, CJ238175

Consensus CDS

CCDS28077.1

UniProtKB/Swiss-Prot

Q64685, Q8K1L1

Related

ENSMUSP00000023601.8, ENSMUST00000023601.14

Conserved Domains (1) summary

pfam00777
Location:174 → 379

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

23043478..23179100

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521876.5 → XP_006521939.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

See identical proteins and their annotated locations for XP_006521939.1

UniProtKB/Swiss-Prot

Q64685, Q8K1L1

Conserved Domains (1) summary

pfam00777
Location:174 → 379

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_011245848.2 → XP_011244150.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

See identical proteins and their annotated locations for XP_011244150.1

UniProtKB/Swiss-Prot

Q64685, Q8K1L1

Conserved Domains (1) summary

pfam00777
Location:174 → 379

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006521875.4 → XP_006521938.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

See identical proteins and their annotated locations for XP_006521938.1

UniProtKB/Swiss-Prot

Q64685, Q8K1L1

Conserved Domains (1) summary

pfam00777
Location:174 → 379

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)