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Pparg peroxisome proliferator activated receptor gamma [ Mus musculus (house mouse) ]

Gene ID: 19016, updated on 21-Apr-2024

Summary

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Official Symbol: Ppargprovided by MGI
Official Full Name: peroxisome proliferator activated receptor gammaprovided by MGI
Primary source: MGI:MGI:97747
See related: Ensembl:ENSMUSG00000000440 AllianceGenome:MGI:97747
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nr1c3; PPARgamma; PPAR-gamma; PPARgamma2; PPAR-gamma2
Summary: This gene encodes a nuclear receptor protein belonging to the peroxisome proliferator-activated receptor (Ppar) family. The encoded protein is a ligand-activated transcription factor that is involved in the regulation of adipocyte differentiation and glucose homeostasis. The encoded protein forms a heterodimer with retinoid X receptors and binds to DNA motifs termed "peroxisome proliferator response elements" to either activate or inhibit gene expression. Mice lacking the encoded protein die at an embryonic stage due to severe defects in placental vascularization. When the embryos lacking this gene are supplemented with healthy placentas, the mutants survive to term, but succumb to lipodystrophy and multiple hemorrhages. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 32.5), mammary gland adult (RPKM 26.1) and 13 other tissues See more
Orthologs: human all
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Genomic context

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Location:: 6 E3; 6 53.41 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (115337828..115467365)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (115360879..115490404)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notoginsenoside R1 targets PPAR-gamma to inhibit hepatic stellate cell activation and ameliorates liver fibrosis.
Title: Notoginsenoside R1 targets PPAR-γ to inhibit hepatic stellate cell activation and ameliorates liver fibrosis.
Exercise-induced BDNF promotes PPARdelta-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery.
Title: Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery.
A Novel Peroxisome Proliferator-Activated Receptor Gamma/Nuclear Factor-Kappa B Activation Pathway is Involved in the Protective Effect of Adipose-Derived Mesenchymal Stem Cells Against Ischemia-Reperfusion Lung Injury.
Title: A Novel Peroxisome Proliferator-Activated Receptor Gamma/Nuclear Factor-Kappa B Activation Pathway is Involved in the Protective Effect of Adipose-Derived Mesenchymal Stem Cells Against Ischemia-Reperfusion Lung Injury.
PPARbeta/delta activation protects against hepatic ischaemia-reperfusion injury.
Title: PPARβ/δ activation protects against hepatic ischaemia-reperfusion injury.
Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARgamma.
Title: Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARγ.
PPARalpha and PPARgamma are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice.
Title: PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice.
KLF2/PPARgamma axis contributes to trauma-induced heterotopic ossification by regulating mitochondrial dysfunction.
Title: KLF2/PPARγ axis contributes to trauma-induced heterotopic ossification by regulating mitochondrial dysfunction.
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors gamma degradation and inhibiting fatty acid oxidation.
Title: Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
PPARalpha/gamma synergism activates UCP1-dependent and -independent thermogenesis and improves mitochondrial dynamics in the beige adipocytes of high-fat fed mice.
Title: PPARα/γ synergism activates UCP1-dependent and -independent thermogenesis and improves mitochondrial dynamics in the beige adipocytes of high-fat fed mice.
FKBP5 activates mitophagy by ablating PPAR-gamma to shape a benign remyelination environment.
Title: FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment.

Submit: New GeneRIF Correction See all GeneRIFs (1122)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (36) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC171387P1 (e-PCR)
- UniSTS:271629

PMC171387P2 (e-PCR)
- UniSTS:271630

PMC171387P3 (e-PCR)
- UniSTS:271631

Pparg (e-PCR), detects polymorphism
- UniSTS:507169

BB157820 (e-PCR)
- UniSTS:186027

D6Oda17 (e-PCR), detects polymorphism
- UniSTS:515324

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding domain binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables LBD domain binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables STAT family protein binding	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info	PubMed
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables arachidonic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	TAS Traceable Author Statement more info	PubMed
enables nuclear receptor coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within diet induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IPI Inferred from Physical Interaction more info	PubMed
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of connective tissue replacement involved in inflammatory response wound healing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuroinflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pancreatic stellate cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptide hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peroxisome proliferator activated receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of adiponectin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of adipose tissue development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of low-density lipoprotein receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to insulin stimulus	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dietary excess	IDA Inferred from Direct Assay more info	PubMed
involved_in response to food	IDA Inferred from Direct Assay more info	PubMed
involved_in response to light stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipid	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoic acid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within white fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within white fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_negative_effect wound healing involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of SUMO ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisome proliferator-activated receptor gamma

Names: nuclear receptor subfamily 1 group C member 3; peroxisome proliferator activated receptor gamma 2; peroxisome proliferator activated receptor gamma 4

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127330.3 → NP_001120802.1 peroxisome proliferator-activated receptor gamma isoform 1

See identical proteins and their annotated locations for NP_001120802.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) contains alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 2. Variants 1, 3, 4, and 5 all encode the same isoform (1).

Source sequence(s)

AC153828, AC171970

Consensus CDS

CCDS51876.1

UniProtKB/Swiss-Prot

P37238

UniProtKB/TrEMBL

A0N0C8, M1VPI1, Q4FJR2

Related

ENSMUSP00000131962.2, ENSMUST00000171644.8

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_001308352.2 → NP_001295281.1 peroxisome proliferator-activated receptor gamma isoform 1

See identical proteins and their annotated locations for NP_001295281.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 2. Variants 1, 3, 4, and 5 all encode the same isoform (1).

Source sequence(s)

AC153828, AC171970

Consensus CDS

CCDS51876.1

UniProtKB/Swiss-Prot

P37238

UniProtKB/TrEMBL

A0N0C8, M1VPI1, Q4FJR2

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_001308354.2 → NP_001295283.1 peroxisome proliferator-activated receptor gamma isoform 1

See identical proteins and their annotated locations for NP_001295283.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 2. Variants 1, 3, 4, and 5 all encode the same isoform (1).

Source sequence(s)

AC153828, AC171970

Consensus CDS

CCDS51876.1

UniProtKB/Swiss-Prot

P37238

UniProtKB/TrEMBL

A0N0C8, M1VPI1, Q4FJR2

Related

ENSMUSP00000145525.2, ENSMUST00000203732.3

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_001410262.1 → NP_001397191.1 peroxisome proliferator-activated receptor gamma isoform 1

Status: VALIDATED

Source sequence(s)

AC153828, AC171970

UniProtKB/TrEMBL

M1VPI1
NM_011146.4 → NP_035276.2 peroxisome proliferator-activated receptor gamma isoform 2

See identical proteins and their annotated locations for NP_035276.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longer isoform (2).

Source sequence(s)

AC153828, AC171970

Consensus CDS

CCDS20439.1

UniProtKB/Swiss-Prot

P37238

UniProtKB/TrEMBL

A0N0C8, Q4FJR2, Q6GU14

Related

ENSMUSP00000000450.4, ENSMUST00000000450.5

Conserved Domains (3) summary

cd06932
Location:237 → 504

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:138 → 221

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:31 → 108

PPARgamma_N; PPAR gamma N-terminal region

RNA

NR_176969.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153828, AC171970
NR_176970.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153828, AC171970
NR_176971.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153828, AC171970

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

115337828..115467365

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505743.4 → XP_006505806.1 peroxisome proliferator-activated receptor gamma isoform X2

See identical proteins and their annotated locations for XP_006505806.1

UniProtKB/Swiss-Prot

P37238

UniProtKB/TrEMBL

A0N0C8, M1VPI1, Q4FJR2

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
XM_006505739.4 → XP_006505802.1 peroxisome proliferator-activated receptor gamma isoform X1

See identical proteins and their annotated locations for XP_006505802.1

UniProtKB/Swiss-Prot

P37238

UniProtKB/TrEMBL

A0N0C8, Q4FJR2

Conserved Domains (3) summary

cd06932
Location:232 → 499

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:133 → 216

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:26 → 103

PPARgamma_N; PPAR gamma N-terminal region
XM_017321455.3 → XP_017176944.1 peroxisome proliferator-activated receptor gamma isoform X2

UniProtKB/Swiss-Prot

P37238

UniProtKB/TrEMBL

A0N0C8, M1VPI1, Q4FJR2

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
XM_006505738.5 → XP_006505801.1 peroxisome proliferator-activated receptor gamma isoform X1

See identical proteins and their annotated locations for XP_006505801.1

UniProtKB/Swiss-Prot

P37238

UniProtKB/TrEMBL

A0N0C8, Q4FJR2

Conserved Domains (3) summary

cd06932
Location:232 → 499

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:133 → 216

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:26 → 103

PPARgamma_N; PPAR gamma N-terminal region
XM_011241252.1 → XP_011239554.1 peroxisome proliferator-activated receptor gamma isoform X2

See identical proteins and their annotated locations for XP_011239554.1

UniProtKB/Swiss-Prot

P37238

UniProtKB/TrEMBL

A0N0C8, M1VPI1, Q4FJR2

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region