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    Pou6f1 POU domain, class 6, transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 19009, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pou6f1provided by MGI
    Official Full Name
    POU domain, class 6, transcription factor 1provided by MGI
    Primary source
    MGI:MGI:102935
    See related
    Ensembl:ENSMUSG00000009739 AllianceGenome:MGI:102935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emb; cns-1; 2310038G18Rik
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; nervous system; sensory organ; and skeletal musculature. Orthologous to human POU6F1 (POU class 6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 22.0), cortex adult (RPKM 16.2) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 F1; 15 56.35 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100473199..100497949, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100575318..100600061, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene STARR-seq mESC enhancer starr_39756 Neighboring gene transcription factor CP2 Neighboring gene STARR-positive B cell enhancer ABC_E7419 Neighboring gene STARR-seq mESC enhancer starr_39757 Neighboring gene STARR-positive B cell enhancer ABC_E4150 Neighboring gene RIKEN cDNA C330013E15 gene Neighboring gene STARR-positive B cell enhancer ABC_E610 Neighboring gene DAZ associated protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain. McClard CK, et al. J Neurosci, 2018 Feb 7. PMID 29305536, Free PMC Article
    2. Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles. Zhang L, et al. BMC Syst Biol, 2011 Sep 29. PMID 21955788, Free PMC Article
    3. Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. Suzuki N, et al. Int J Gynecol Cancer, 2010 Feb. PMID 20134265
    4. The in vivo form of the murine class VI POU protein Emb is larger than that encoded by previously described transcripts. Relaix F, et al. Gene, 2004 May 26. PMID 15177678
    5. NMDA receptor activation in differentiating cerebellar cell cultures regulates the expression of a new POU gene, Cns-1. Bulleit RF, et al. J Neurosci, 1994 Mar. PMID 7907365, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation.
      Title: RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation.
    2. POU6f1 is necessary for proper dendrite specification and patterning, as well as synapse development and function in adult-born neurons
      Title: POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain.
    3. pou6f1 significantly regulates tmem59 and might play an important role in the differentiation of neural stem cells in mouse brain.
      Title: Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles.
    4. POU6F1 siRNA suppressed the proliferation of clear cell adenocarcinoma transplanted into nude mice.
      Title: Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target.
    5. These results demonstrate the importance of the Emb-MEF2D-histone transacetylase p300 complex in the transcriptional regulation of the cardiac actin gene and suggest a potential role in chromatin remodeling associated with muscle gene activation.
      Title: A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    POU domain, class 6, transcription factor 1
    Names
    octamer-binding transcription factor EMB
    transcription regulatory protein MCP-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304965.2 → NP_001291894.1  POU domain, class 6, transcription factor 1 isoform 1

      See identical proteins and their annotated locations for NP_001291894.1

      Status: VALIDATED

      Source sequence(s)
      AC123724
      Consensus CDS
      CCDS79411.1
      UniProtKB/TrEMBL
      Q5U4D4, Q6X2S0
      Related
      ENSMUSP00000073504.7, ENSMUST00000073837.13
      Conserved Domains (2) summary
      pfam00046
      Location:512 → 565
      Homeobox; Homeobox domain
      cl22952
      Location:414 → 488
      Pou; Pou domain - N-terminal to homeobox domain

    2. NM_001404294.1 → NP_001391223.1  POU domain, class 6, transcription factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123724

    3. NM_001404295.1 → NP_001391224.1  POU domain, class 6, transcription factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123724
      UniProtKB/Swiss-Prot
      Q07916, Q91XK3

    4. NM_001404296.1 → NP_001391225.1  POU domain, class 6, transcription factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123724
      UniProtKB/Swiss-Prot
      Q07916, Q91XK3

    5. NM_001404297.1 → NP_001391226.1  POU domain, class 6, transcription factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123724
      UniProtKB/Swiss-Prot
      Q07916, Q91XK3
      Related
      ENSMUSP00000145707.2, ENSMUST00000176271.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100473199..100497949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248418.2 → XP_030104278.1  POU domain, class 6, transcription factor 1 isoform X5

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:98 → 390
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:511 → 565
      Homeobox; Homeobox domain
      cl22952
      Location:413 → 487
      Pou; Pou domain - N-terminal to homeobox domain

    2. XM_006520614.5 → XP_006520677.1  POU domain, class 6, transcription factor 1 isoform X8

      Conserved Domains (3) summary
      PRK12323
      Location:46 → 263
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam00046
      Location:337 → 391
      Homeobox; Homeobox domain
      cl22952
      Location:287 → 313
      Pou; Pou domain - N-terminal to homeobox domain

    3. XM_017316508.3 → XP_017171997.1  POU domain, class 6, transcription factor 1 isoform X6

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:58 → 378
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:478 → 532
      Homeobox; Homeobox domain
      cl22952
      Location:380 → 454
      Pou; Pou domain - N-terminal to homeobox domain

    4. XM_017316509.2 → XP_017171998.1  POU domain, class 6, transcription factor 1 isoform X7

      Conserved Domains (1) summary
      PHA03247
      Location:48 → 452
      PHA03247; large tegument protein UL36; Provisional

    5. XM_030248417.2 → XP_030104277.1  POU domain, class 6, transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:31 → 406
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:527 → 581
      Homeobox; Homeobox domain
      cl22952
      Location:429 → 503
      Pou; Pou domain - N-terminal to homeobox domain

    6. XM_006520609.4 → XP_006520672.1  POU domain, class 6, transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:50 → 424
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:545 → 599
      Homeobox; Homeobox domain
      cl22952
      Location:447 → 521
      Pou; Pou domain - N-terminal to homeobox domain

    7. XM_030248416.1 → XP_030104276.1  POU domain, class 6, transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:48 → 425
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:546 → 600
      Homeobox; Homeobox domain
      cl22952
      Location:448 → 522
      Pou; Pou domain - N-terminal to homeobox domain

    8. XM_006520608.4 → XP_006520671.1  POU domain, class 6, transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:48 → 425
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:546 → 600
      Homeobox; Homeobox domain
      cl22952
      Location:448 → 522
      Pou; Pou domain - N-terminal to homeobox domain

    9. XM_030248419.1 → XP_030104279.1  POU domain, class 6, transcription factor 1 isoform X9

      Conserved Domains (3) summary
      PRK14951
      Location:41 → 158
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      pfam00046
      Location:267 → 321
      Homeobox; Homeobox domain
      cl22952
      Location:169 → 243
      Pou; Pou domain - N-terminal to homeobox domain

    10. XM_036159263.1 → XP_036015156.1  POU domain, class 6, transcription factor 1 isoform X10

      Conserved Domains (2) summary
      PHA03247
      Location:58 → 295
      PHA03247; large tegument protein UL36; Provisional
      PRK07994
      Location:170 → 272
      PRK07994; DNA polymerase III subunits gamma and tau; Validated

    RNA

    1. XR_004938810.1 RNA Sequence

      Related
      ENSMUST00000176140.8

    2. XR_004938809.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010127.3: Suppressed sequence

      Description
      NM_010127.3: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07916.1 GenPept UniProtKB/Swiss-Prot:Q07916

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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