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Conserved domains on  [gi|1720383688|ref|XP_030104278|]
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POU domain, class 6, transcription factor 1 isoform X5 [Mus musculus]

Protein Classification

POU family transcription factor( domain architecture ID 11036637)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pou super family cl22952
Pou domain - N-terminal to homeobox domain;
413-487 1.24e-38

Pou domain - N-terminal to homeobox domain;


The actual alignment was detected with superfamily member smart00352:

Pssm-ID: 473999  Cd Length: 75  Bit Score: 136.41  E-value: 1.24e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720383688  413 EDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 487
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
509-565 1.55e-21

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.94  E-value: 1.55e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383688 509 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN 565
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 98-390 1.27e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 1.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688   98 PSPEPASGITDPDAAGCTSCPPGQVAGQQGLAVWTI-----PTATVAALPGLTAASPTGGTFKPPLAGLQAAVLNTAlPT 172
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAapappAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG-PP 2780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  173 PVQAAPPIQASSPAQPRPPAQPQPLFQTQPLLQTTPAIlpqPTAATVAAPTPKTVDATPQITVQPAGFAFSPGIISAASL 252
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL---PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  253 GGQTQILGSLTTAPVITNTIPSMPGISsqiltnaqgqvigalpwvvnsaSVATPAPAQSLQVQAVTPqlllnaqgqviat 332
Cdd:PHA03247  2858 PGGDVRRRPPSRSPAAKPAAPARPPVR----------------------RLARPAVSRSTESFALPP------------- 2902

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  333 LASSPLPQPVAVRKPN-TPESPAKSEVQPIQPTQAVPQ-PAVILTSPTPALKPSAATPIP 390
Cdd:PHA03247  2903 DQPERPPQPQAPPPPQpQPQPPPPPQPQPPPPPPPRPQpPLAPTTDPAGAGEPSGAVPQP 2962
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
413-487 1.24e-38

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 136.41  E-value: 1.24e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720383688  413 EDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 487
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
416-487 1.56e-35

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 127.78  E-value: 1.56e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720383688 416 INLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 487
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
509-565 1.55e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.94  E-value: 1.55e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383688 509 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN 565
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 508-564 1.87e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 81.91  E-value: 1.87e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383688  508 KRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLK 564
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 509-567 2.43e-18

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 78.82  E-value: 2.43e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720383688 509 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTS 567
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
456-564 7.13e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.14  E-value: 7.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 456 QSAICRFEKLDItpKSAQKLKPvlEKWLMEAElrNQEGQQNLMEFVGGEPSKKRKR-RTsfTPQAIEALNAYFEKNPLPT 534
Cdd:COG5576     6 MQPLSALESQRM--PQIRTIKT--TKNKREVE--AADSEMKLERKQDGSSPPKSKRrRT--TDEQLMVLEREFEINPYPS 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720383688 535 GQEITEIAKELNYDREVVRVWFCNRRQTLK 564
Cdd:COG5576    78 SITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 98-390 1.27e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 1.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688   98 PSPEPASGITDPDAAGCTSCPPGQVAGQQGLAVWTI-----PTATVAALPGLTAASPTGGTFKPPLAGLQAAVLNTAlPT 172
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAapappAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG-PP 2780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  173 PVQAAPPIQASSPAQPRPPAQPQPLFQTQPLLQTTPAIlpqPTAATVAAPTPKTVDATPQITVQPAGFAFSPGIISAASL 252
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL---PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  253 GGQTQILGSLTTAPVITNTIPSMPGISsqiltnaqgqvigalpwvvnsaSVATPAPAQSLQVQAVTPqlllnaqgqviat 332
Cdd:PHA03247  2858 PGGDVRRRPPSRSPAAKPAAPARPPVR----------------------RLARPAVSRSTESFALPP------------- 2902

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  333 LASSPLPQPVAVRKPN-TPESPAKSEVQPIQPTQAVPQ-PAVILTSPTPALKPSAATPIP 390
Cdd:PHA03247  2903 DQPERPPQPQAPPPPQpQPQPPPPPQPQPPPPPPPRPQpPLAPTTDPAGAGEPSGAVPQP 2962
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 111-387 1.19e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 44.95  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 111 AAGCTSCPPGQVAGQQGLAVWTIPTATVAALPGLTAASPTGGTFKPPLAGLQAAVLNTALPTPVQAAPPIQASSPAQPRP 190
Cdd:pfam17823 107 ADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAAS 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 191 PAQPQPLFQTQPLLQTTPAILPQPTAATVAA----PTPKTVDA-TPQITVQPAGFAFSPGIISAASLGGQTQILGSLTTA 265
Cdd:pfam17823 187 STTAASSAPTTAASSAPATLTPARGISTAATatghPAAGTALAaVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 266 PVITNT---IPSMPGISSQILTN-------------AQG---QVIGALPwVVNSASVATPAPAQSlQVQAVTPQLLLNAQ 326
Cdd:pfam17823 267 AGTINMgdpHARRLSPAKHMPSDtmarnpaapmgaqAQGpiiQVSTDQP-VHNTAGEPTPSPSNT-TLEPNTPKSVASTN 344

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720383688 327 GQVIATL-------ASSPLPQPVAVRKPNTPESPAKSEVQPIQPTQAVPQPAVILTSPTPALKPSAAT 387
Cdd:pfam17823 345 LAVVTTTkaqakepSASPVPVLHTSMIPEVEATSPTTQPSPLLPTQGAAGPGILLAPEQVATEATAGT 412
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
413-487 1.24e-38

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 136.41  E-value: 1.24e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720383688  413 EDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 487
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
416-487 1.56e-35

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 127.78  E-value: 1.56e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720383688 416 INLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 487
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
509-565 1.55e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.94  E-value: 1.55e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383688 509 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN 565
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 508-564 1.87e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 81.91  E-value: 1.87e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383688  508 KRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLK 564
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 509-567 2.43e-18

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 78.82  E-value: 2.43e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720383688 509 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTS 567
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
456-564 7.13e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.14  E-value: 7.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 456 QSAICRFEKLDItpKSAQKLKPvlEKWLMEAElrNQEGQQNLMEFVGGEPSKKRKR-RTsfTPQAIEALNAYFEKNPLPT 534
Cdd:COG5576     6 MQPLSALESQRM--PQIRTIKT--TKNKREVE--AADSEMKLERKQDGSSPPKSKRrRT--TDEQLMVLEREFEINPYPS 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1720383688 535 GQEITEIAKELNYDREVVRVWFCNRRQTLK 564
Cdd:COG5576    78 SITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 98-390 1.27e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 1.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688   98 PSPEPASGITDPDAAGCTSCPPGQVAGQQGLAVWTI-----PTATVAALPGLTAASPTGGTFKPPLAGLQAAVLNTAlPT 172
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAapappAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG-PP 2780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  173 PVQAAPPIQASSPAQPRPPAQPQPLFQTQPLLQTTPAIlpqPTAATVAAPTPKTVDATPQITVQPAGFAFSPGIISAASL 252
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL---PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  253 GGQTQILGSLTTAPVITNTIPSMPGISsqiltnaqgqvigalpwvvnsaSVATPAPAQSLQVQAVTPqlllnaqgqviat 332
Cdd:PHA03247  2858 PGGDVRRRPPSRSPAAKPAAPARPPVR----------------------RLARPAVSRSTESFALPP------------- 2902

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  333 LASSPLPQPVAVRKPN-TPESPAKSEVQPIQPTQAVPQ-PAVILTSPTPALKPSAATPIP 390
Cdd:PHA03247  2903 DQPERPPQPQAPPPPQpQPQPPPPPQPQPPPPPPPRPQpPLAPTTDPAGAGEPSGAVPQP 2962
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 111-387 1.19e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 44.95  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 111 AAGCTSCPPGQVAGQQGLAVWTIPTATVAALPGLTAASPTGGTFKPPLAGLQAAVLNTALPTPVQAAPPIQASSPAQPRP 190
Cdd:pfam17823 107 ADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAAS 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 191 PAQPQPLFQTQPLLQTTPAILPQPTAATVAA----PTPKTVDA-TPQITVQPAGFAFSPGIISAASLGGQTQILGSLTTA 265
Cdd:pfam17823 187 STTAASSAPTTAASSAPATLTPARGISTAATatghPAAGTALAaVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 266 PVITNT---IPSMPGISSQILTN-------------AQG---QVIGALPwVVNSASVATPAPAQSlQVQAVTPQLLLNAQ 326
Cdd:pfam17823 267 AGTINMgdpHARRLSPAKHMPSDtmarnpaapmgaqAQGpiiQVSTDQP-VHNTAGEPTPSPSNT-TLEPNTPKSVASTN 344

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720383688 327 GQVIATL-------ASSPLPQPVAVRKPNTPESPAKSEVQPIQPTQAVPQPAVILTSPTPALKPSAAT 387
Cdd:pfam17823 345 LAVVTTTkaqakepSASPVPVLHTSMIPEVEATSPTTQPSPLLPTQGAAGPGILLAPEQVATEATAGT 412
PHA03247 PHA03247
large tegument protein UL36; Provisional
 37-253 5.82e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 5.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688   37 LPAEEESKGLESVAAGGSQSGGPVEASGPAEAGSCDPDHSAEATVAARSPSESCPSDcHLQPSPEPASGITDPDAAGCTS 116
Cdd:PHA03247  2750 TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD-PPAAVLAPAAALPPAASPAGPL 2828

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  117 CPPGQVAgqqglavwtiPTATVAALPGLTAASPTGGTFKP-------PLAGLQAAVLNTALPTPVQ--AAPPIQASSPAQ 187
Cdd:PHA03247  2829 PPPTSAQ----------PTAPPPPPGPPPPSLPLGGSVAPggdvrrrPPSRSPAAKPAAPARPPVRrlARPAVSRSTESF 2898

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383688  188 PRPPAQPQPLFQTQPLLQ-TTPAILPQPTAATVAAPTPKTVDATPQITVQPAGFAFSPGIISAASLG 253
Cdd:PHA03247  2899 ALPPDQPERPPQPQAPPPpQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 276-416 3.94e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 40.23  E-value: 3.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 276 PGISSQILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVTPQlLLNAQGQVIATLASSPLPQPVAVRKPNTPESPAK 355
Cdd:PRK07994  377 PAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQ-LLAARQQLQRAQGATKAKKSEPAAASRARPVNSA 455

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720383688 356 SEVQPIQPTQAVPQPAVILTSPTPALKPSAATPIPITCSETPT-VSQLVSKPHTPSLDEDGI 416
Cdd:PRK07994  456 LERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKaLKKALEHEKTPELAAKLA 517
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 285-402 4.95e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.70  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 285 NAQGQVIGALPWVVNSASVATPAPA-----QSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPNTPES-PAKSEV 358
Cdd:PRK14951  368 AAAEAAAPAEKKTPARPEAAAPAAApvaqaAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAaPAAVAL 447

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720383688 359 QPIQPTQAVPQPAVI--LTSPTPALKPSAATPIPITCSETPTVSQL 402
Cdd:PRK14951  448 APAPPAQAAPETVAIpvRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
47-224 6.55e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.45  E-value: 6.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  47 ESVAAGGSQSGGPVEASGPAEAGSCDPDHSAEATVAARSPSESCPSDCHLQPSPEPAS--GITDPDAAGCTSCPPGQVAG 124
Cdd:PRK07003  359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAaaAATRAEAPPAAPAPPATADR 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 125 QQGLAVWTIPTATVAALPGLTAASPTGGTFKPPLAGLQAAVLNTALPTPVQAAPPIQASSPAQPRPPAQPQPLFQTQPLL 204
Cdd:PRK07003  439 GDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASR 518

                         170       180
                  ....*....|....*....|
gi 1720383688 205 QTTPAIlPQPTAATVAAPTP 224
Cdd:PRK07003  519 EDAPAA-AAPPAPEARPPTP 537
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 202-411 6.65e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 39.68  E-value: 6.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  202 PLLQTTPaiLPQPTAATVAAPTPKTVDATPQITVQPAGFAFSPGIISAASLGGQTQILGSLTTAPVITNTIPSMPGISSQ 281
Cdd:PRK10263   309 PLLNGAP--ITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQY 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  282 iltnAQGQVIGALPWvvnsASVATPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPNTPESPAKSEVQPI 361
Cdd:PRK10263   387 ----AQPAVQYNEPL----QQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAP 458

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720383688  362 QPTQAVPQPAVILTSPTPALKPSAATPIPITCSETPTVSQlvSKPHTPSL 411
Cdd:PRK10263   459 QSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEE--TKPARPPL 506
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 134-237 7.07e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 39.46  E-value: 7.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 134 PTATVAALPGLTAASPTGGTfkpplAGLQAAVLNTALPTPVQAAPPIQASSPAQPRPPAQPQPLFQTQPLLQTTPAILPQ 213
Cdd:PRK07994  368 PEVPPQSAAPAASAQATAAP-----TAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSE 442

                          90       100
                  ....*....|....*....|....
gi 1720383688 214 PTAATVAAPTPKTVDATPQITVQP 237
Cdd:PRK07994  443 PAAASRARPVNSALERLASVRPAP 466
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 297-429 7.51e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.02  E-value: 7.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 297 VVNSASVATPAPAQSLQVQAVTPQLllnAQGQVIATLASSPLPQPVAVRKPNTPESPAKSEV-QPIQPTQAVPQPAVILT 375
Cdd:PRK14950  359 LLVPVPAPQPAKPTAAAPSPVRPTP---APSTRPKAAAAANIPPKEPVRETATPPPVPPRPVaPPVPHTPESAPKLTRAA 435

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720383688 376 SPTPAlKPSAATPIPitcsetptvsqlvSKPHTPSLDEDGINLEEIREFAKNFK 429
Cdd:PRK14950  436 IPVDE-KPKYTPPAP-------------PKEEEKALIADGDVLEQLEAIWKQIL 475
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 59-368 8.39e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.13  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  59 PVEASGPAEAGSCdpdhSAEATVAARSPSESCPSDCHLQPSPEPASGITDPDAAGCTScPPGQVAGQQGLAVWTIPTATV 138
Cdd:pfam05109 455 PTNLTAPASTGPT----VSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTS-PTSAVTTPTPNATSPTPAVTT 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 139 ----AALPGLTAASPTGGTFKP------PLAGLQAAVLNTALPTPVQAAPpiqASSPAQPRPPAQPQPLFQTQPLLQTTP 208
Cdd:pfam05109 530 ptpnATSPTLGKTSPTSAVTTPtpnatsPTPAVTTPTPNATIPTLGKTSP---TSAVTTPTPNATSPTVGETSPQANTTN 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 209 AILPQPTAATVAAPTPKtvDATPQITVQPAGFAFSpgiiSAASLGGQTQILGSLTTAPVITNTIPSMPGISSQILTNAQg 288
Cdd:pfam05109 607 HTLGGTSSTPVVTSPPK--NATSAVTTGQHNITSS----STSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGE- 679

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 289 QVIGALPWVVNSASVATPAPAqslqvqavtPQLLLNAQGQVIATLASSPLPQPVAVRKpNTPESPAKSEVQPIQPTQAVP 368
Cdd:pfam05109 680 NITQVTPASTSTHHVSTSSPA---------PRPGTTSQASGPGNSSTSTKPGEVNVTK-GTPPKNATSPQAPSGQKTAVP 749
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 148-405 9.32e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 9.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 148 SPTGGTFKPPLAGLQAAVLNTALPTPVQAAPPIQASsPAQPRPPAQPQPLFQTQPLLQTTPAILPQPTAATVAAPTPKTV 227
Cdd:pfam03154 176 AQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGS-PATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQ 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 228 DATPQITvqpagfafSPGIISAASLGGQTQILG-SLTTAPV-ITNTIPSMP-GISSQiltNAQGQvigalpwVVNSASVA 304
Cdd:pfam03154 255 PPPPSQV--------SPQPLPQPSLHGQMPPMPhSLQTGPShMQHPVPPQPfPLTPQ---SSQSQ-------VPPGPSPA 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688 305 TPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPNTPESP---AKSEVQPIQPTQAVPQPAVILTSPTPAL 381
Cdd:pfam03154 317 APGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQlpnPQSHKHPPHLSGPSPFQMNSNLPPPPAL 396

                         250       260
                  ....*....|....*....|....
gi 1720383688 382 KPSAATPIPITCSETPTVSQLVSK 405
Cdd:pfam03154 397 KPLSSLSTHHPPSAHPPPLQLMPQ 420
PHA03247 PHA03247
large tegument protein UL36; Provisional
 59-415 9.38e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 9.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688   59 PVEASGPAEAGscdpdhsaeatvAARSPSESCPSDCHLQPSPEPASGITDPDAAGCTSCPPGQVAGQQGLAvwtiptatv 138
Cdd:PHA03247  2483 PAEARFPFAAG------------AAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLE--------- 2541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  139 aalpglTAASPTGGTFKPPLA-GLQAAVLNTALPTPVQAAPPIQASSPAQPRPPAQPQplfqtQPLLQTTPAILPQPTAA 217
Cdd:PHA03247  2542 ------ELASDDAGDPPPPLPpAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPP-----QSARPRAPVDDRGDPRG 2610

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  218 TvAAPTPKTVDATPQITVQPAG--FAFSPGIISAASLGGQTQILGSLTTAPVITNTIPSMPGISSQILTNAQGQVIGALP 295
Cdd:PHA03247  2611 P-APPSPLPPDTHAPDPPPPSPspAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR 2689

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  296 WVVNS-ASVA-------TPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAV--------------RKPNTPESP 353
Cdd:PHA03247  2690 PTVGSlTSLAdppppppTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAgpatpggparparpPTTAGPPAP 2769

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383688  354 AKSEVQPIQPTQAVPQPAV---------------------ILTSPTPALKPSA--ATPIPITCSETPTVSQLVSKPHTPS 410
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRPAVaslsesreslpspwdpadppaAVLAPAAALPPAAspAGPLPPPTSAQPTAPPPPPGPPPPS 2849


                   ....*
gi 1720383688  411 LDEDG 415
Cdd:PHA03247  2850 LPLGG 2854
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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