Mug1 murinoglobulin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mug1provided by MGI
Official Full Name: murinoglobulin 1provided by MGI
Primary source: MGI:MGI:99837
See related: Ensembl:ENSMUSG00000059908 AllianceGenome:MGI:99837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable endopeptidase inhibitor activity and protease binding activity. Acts upstream of or within embryo implantation. Predicted to be located in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in otitis media. Orthologous to human PZP (PZP alpha-2-macroglobulin like) and A2ML1 (alpha-2-macroglobulin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward liver adult (RPKM 215.5) See more
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Genomic context

Location:: 6 F1; 6 57.52 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (121815455..121866016)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (121838496..121889057)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophages secrete murinoglobulin-1 and galectin-3 to regulate neutrophil degranulation after myocardial infarction.
Title: Macrophages secrete murinoglobulin-1 and galectin-3 to regulate neutrophil degranulation after myocardial infarction.
To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice
Title: Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice.
susceptibility to T. cruzi infection of mice that are deficient only in alpha2-macroglobulins (AM-KO) or in both MAM and monomeric murinoglobulin-1 (MM-KO), relative to the wild type (WT)
Title: Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo implantation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: murinoglobulin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008645.3 → NP_032671.2 murinoglobulin-1 precursor

See identical proteins and their annotated locations for NP_032671.2

Status: VALIDATED

Source sequence(s)

AC116120, AK144541, AK149376, D17910

Consensus CDS

CCDS39618.1

UniProtKB/Swiss-Prot

P28665, Q3UNE7, Q80XE6

Related

ENSMUSP00000032228.9, ENSMUST00000032228.9

Conserved Domains (6) summary

cd02897
Location:960 → 1266

A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...

pfam00207
Location:740 → 830

A2M; Alpha-2-macroglobulin family

pfam01835
Location:129 → 221

A2M_N; MG2 domain

pfam07677
Location:1378 → 1465

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1013 → 1268

A2M_comp; A-macroglobulin complement component

pfam07703
Location:449 → 598

A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

121815455..121866016

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505698.4 → XP_006505761.1 murinoglobulin-1 isoform X1

UniProtKB/TrEMBL

A0A0N4SVU1

Conserved Domains (7) summary

cd02897
Location:960 → 1266

A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...

pfam00207
Location:740 → 830

A2M; Alpha-2-macroglobulin family

pfam07677
Location:1378 → 1465

A2M_recep; A-macroglobulin receptor

pfam17789
Location:340 → 439

MG4; Macroglobulin domain MG4

pfam17791
Location:223 → 299

MG3; Macroglobulin domain MG3

pfam01835
Location:129 → 221

A2M_N; MG2 domain

pfam07703
Location:449 → 599

A2M_N_2; Alpha-2-macroglobulin family N-terminal region