|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
960-1266 |
3.10e-165 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 497.87 E-value: 3.10e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 960 AIRNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNgeREG 1039
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESD--KSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1040 NTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSAYITMALLESSLPAT 1119
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1120 HPVVSKALSCLESSWKTIeqernaSFVYTKALMAYAFALAGnQNKRDEILKSLDEEAIKENNSIHWKRPQKSrkSEHHLY 1199
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRPPPS--EEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568940990 1200 KPQASSAEVEMNAYVVLARLTAQpapsPEDLTLSMSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1266
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
740-830 |
2.54e-37 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
:
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 135.41 E-value: 2.54e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 740 TWVWDIVTVNSTGLAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFKPFFVEVSLPYSVVRGEAFMLKATVMNY 819
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 568940990 820 LPTSMQMSVQL 830
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
97-1332 |
2.18e-36 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 151.00 E-value: 2.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 97 SDEEDFLYVDIK-GPTHEFSKRK-AVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKMLRPLNELlPL-AYIEDP--K 171
Cdd:COG2373 337 RKGGDFAFLDLDdGPALDLSDFDvGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPdgK 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 172 KNRIMQWRDikTENGLKQMSFSLAAEPIQGPYKIVVHKESGEKE-EHSFTVMEFVLPRFNVDLKVPNAMSVNDEVLSVTA 250
Cdd:COG2373 416 EVRRQTLTL--NEFGGYSFSFPLPEDAPTGTWRLELYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTV 493
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 251 CGKYTYGKPVPG-HVKINV----------------------CRETETGcREVNSQLDNNGCSTQEVNITELQSKKRNYEV 307
Cdd:COG2373 494 DARYLFGAPAAGlKVEGEVtlrpartafpgypgyrfgdpdeEFEPEEL-DLGEGTLDADGKASLSLPLPDAPDAPGPLRA 572
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 308 QlfhVNATVTEEGtGLEFSRSGTTKIERiTNKLIFLKAD--SHFRHGIPFFVKVRLVDIKGDPIPNEKVFIKAQELSYTS 385
Cdd:COG2373 573 T---VEASVFESG-GRPVTRSATVPVHP-ADFYVGIRLPlfDGDPEGAPATFEVVAVDPDGKPVAGKGLKVELYREEWRY 647
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 386 ATTTDQHGLAEFSIDTTCISGSSLHIKVNHKEEDSCSYF------YCMEERHASAKHVA----YAVYSLSKSyiyLDT-- 453
Cdd:COG2373 648 VWYKSDDGGWRYESQEKEEPVAEGTLTTGADGPASLSLTpvewgrYRLEVKDPDGGLATsvrfYAGGNASWG---AERpd 724
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 454 --------------ETSSILpcnqihtVQAHFILKGdlgvlkelifyyLVMAQGS-IIQTgnHTHQVEPGEAPVkgkfal 518
Cdd:COG2373 725 rlelsldkesykpgETAKLL-------IQSPFAGRA------------LVTVERDgVLET--QWVDVKGGGTTV------ 777
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 519 EIPVEFSMVPMAkmliY---TILPDGEVIAD--------SVNFEIEKCLRnKVDLRFSTSQSL-PASQTRLQVTASPQSl 586
Cdd:COG2373 778 EIPVTEDWAPNA----YvsaTLVRPGDSTANdmparaygVAPLPVDPPAR-RLKVELTAPEKLrPGETLTVTVKVKGAA- 851
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 587 cG------LRAVDQSVLLLKPESELSP-SWIYnlpgmQQNKFVPSSRlsedqedcilysswlaekhtnlvphgtekDVYR 659
Cdd:COG2373 852 -GkaaevtLAAVDEGILNLTGYKTPDPlDFFY-----GKRALGVETR-----------------------------DLYG 896
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 660 YVedmgLTAFTNLMIKLPIicfdyGMvpisaprvefDLAFTPEiswslrttlskRPEEPPRKDpssndpltetirkyFPE 739
Cdd:COG2373 897 RL----IGAFGGAAGALRS-----GG----------DGALGRG-----------GNPKPPRKR--------------FKP 932
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 740 TWVWD-IVTVNSTGLAEVEMTVPDTITEWKAGALCLSnDTGLGlSSVVPLQAFKPFFVEVSLPYSVVRGEAFMLKATVMN 818
Cdd:COG2373 933 VALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFN 1010
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 819 YLPTSMQMSVQLEASPDFTavPVGDDQDSYCLSANGRHTSSWLVTPKSLGNVNFSVSAEAQqssepcgsevatvpetGRK 898
Cdd:COG2373 1011 LTGKAGTVTVTLEASGGLT--LEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------GES 1072
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 899 DTVVKVLIVEPEGIKQEHTFSSLFcasDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIRNTQNLLHMPYGCGEQN 978
Cdd:COG2373 1073 DAREVELPVRPANPLVTRATSGVL---APGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQT 1149
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 979 MVLFAPNIYVLKyLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGdqnGEREGNTWLTAFVLKSFAQARAF- 1057
Cdd:COG2373 1150 TSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAg 1225
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1058 IFIDESHITHAFTWLSQKQKDNGcfrssgslfnnAMKGGVDDEMTLSAYITMALLESSLPATHPVvskalsclesswKTI 1137
Cdd:COG2373 1226 YAVPDDALDRALDYLRNYLRNPW-----------EIEYDDAYRLAVRAYALYVLARAGKADLGDL------------RYL 1282
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1138 EQERNASF-VYTKALMAYAFALAGNQNKRDEILKSLDEEAIKENNSIHWkrpqksrkseHHLYkpqasSAEVEMNAYVVL 1216
Cdd:COG2373 1283 YDRRKDALsPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALALA 1347
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1217 ARLTAQP-APSPEDLtlsmstIMWLTKQQNSnGGFSSTQDTVVALDALSKYgavtFSRSQKTTLVTIQSTGSfSQKFQVE 1295
Cdd:COG2373 1348 LLAELGPdAPLAPKL------ARWLAKALKS-GRWLSTQETAWALLALAAY----ARAAGASPDFTATLTLD-GKTLPLT 1415
|
1290 1300 1310
....*....|....*....|....*....|....*...
gi 568940990 1296 NSNRLLLQQVALPDI-PGDYTISVSGEGCVYAQTMLRY 1332
Cdd:COG2373 1416 GRGPLARVTLPAAELlAGPLTITNTGDGPLYYTLTLSG 1453
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1376-1466 |
2.15e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 124.22 E-value: 2.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1376 PASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTE-VSNNNVLIYLDQVTNQTLAFSFIIQQDIPVRNLQPAIVKVYDY 1454
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 568940990 1455 YETDEMAFAEYS 1466
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
960-1266 |
3.10e-165 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 497.87 E-value: 3.10e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 960 AIRNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNgeREG 1039
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESD--KSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1040 NTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSAYITMALLESSLPAT 1119
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1120 HPVVSKALSCLESSWKTIeqernaSFVYTKALMAYAFALAGnQNKRDEILKSLDEEAIKENNSIHWKRPQKSrkSEHHLY 1199
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRPPPS--EEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568940990 1200 KPQASSAEVEMNAYVVLARLTAQpapsPEDLTLSMSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1266
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
950-1266 |
8.16e-155 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 471.40 E-value: 8.16e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 950 FSVMGDILSSAI----RNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDG 1025
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1026 SYSAFGDqngeREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSA 1105
Cdd:pfam07678 81 SYSAFGH----SPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1106 YITMALLES-----SLPATHPVVSKALSCLESswktiEQERNASFVYTKALMAYAFALAGNQNKRDEILKSLDEEAIKEN 1180
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1181 NSIHWKRPQKSRKSEHHLYKPQASSAEVEMNAYVVLARLTaqpapsPEDLTLSMSTIMWLTKQQNSNGGFSSTQDTVVAL 1260
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYLL------LGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 568940990 1261 DALSKY 1266
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
740-830 |
2.54e-37 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 135.41 E-value: 2.54e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 740 TWVWDIVTVNSTGLAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFKPFFVEVSLPYSVVRGEAFMLKATVMNY 819
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 568940990 820 LPTSMQMSVQL 830
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
97-1332 |
2.18e-36 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 151.00 E-value: 2.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 97 SDEEDFLYVDIK-GPTHEFSKRK-AVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKMLRPLNELlPL-AYIEDP--K 171
Cdd:COG2373 337 RKGGDFAFLDLDdGPALDLSDFDvGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPdgK 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 172 KNRIMQWRDikTENGLKQMSFSLAAEPIQGPYKIVVHKESGEKE-EHSFTVMEFVLPRFNVDLKVPNAMSVNDEVLSVTA 250
Cdd:COG2373 416 EVRRQTLTL--NEFGGYSFSFPLPEDAPTGTWRLELYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTV 493
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 251 CGKYTYGKPVPG-HVKINV----------------------CRETETGcREVNSQLDNNGCSTQEVNITELQSKKRNYEV 307
Cdd:COG2373 494 DARYLFGAPAAGlKVEGEVtlrpartafpgypgyrfgdpdeEFEPEEL-DLGEGTLDADGKASLSLPLPDAPDAPGPLRA 572
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 308 QlfhVNATVTEEGtGLEFSRSGTTKIERiTNKLIFLKAD--SHFRHGIPFFVKVRLVDIKGDPIPNEKVFIKAQELSYTS 385
Cdd:COG2373 573 T---VEASVFESG-GRPVTRSATVPVHP-ADFYVGIRLPlfDGDPEGAPATFEVVAVDPDGKPVAGKGLKVELYREEWRY 647
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 386 ATTTDQHGLAEFSIDTTCISGSSLHIKVNHKEEDSCSYF------YCMEERHASAKHVA----YAVYSLSKSyiyLDT-- 453
Cdd:COG2373 648 VWYKSDDGGWRYESQEKEEPVAEGTLTTGADGPASLSLTpvewgrYRLEVKDPDGGLATsvrfYAGGNASWG---AERpd 724
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 454 --------------ETSSILpcnqihtVQAHFILKGdlgvlkelifyyLVMAQGS-IIQTgnHTHQVEPGEAPVkgkfal 518
Cdd:COG2373 725 rlelsldkesykpgETAKLL-------IQSPFAGRA------------LVTVERDgVLET--QWVDVKGGGTTV------ 777
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 519 EIPVEFSMVPMAkmliY---TILPDGEVIAD--------SVNFEIEKCLRnKVDLRFSTSQSL-PASQTRLQVTASPQSl 586
Cdd:COG2373 778 EIPVTEDWAPNA----YvsaTLVRPGDSTANdmparaygVAPLPVDPPAR-RLKVELTAPEKLrPGETLTVTVKVKGAA- 851
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 587 cG------LRAVDQSVLLLKPESELSP-SWIYnlpgmQQNKFVPSSRlsedqedcilysswlaekhtnlvphgtekDVYR 659
Cdd:COG2373 852 -GkaaevtLAAVDEGILNLTGYKTPDPlDFFY-----GKRALGVETR-----------------------------DLYG 896
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 660 YVedmgLTAFTNLMIKLPIicfdyGMvpisaprvefDLAFTPEiswslrttlskRPEEPPRKDpssndpltetirkyFPE 739
Cdd:COG2373 897 RL----IGAFGGAAGALRS-----GG----------DGALGRG-----------GNPKPPRKR--------------FKP 932
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 740 TWVWD-IVTVNSTGLAEVEMTVPDTITEWKAGALCLSnDTGLGlSSVVPLQAFKPFFVEVSLPYSVVRGEAFMLKATVMN 818
Cdd:COG2373 933 VALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFN 1010
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 819 YLPTSMQMSVQLEASPDFTavPVGDDQDSYCLSANGRHTSSWLVTPKSLGNVNFSVSAEAQqssepcgsevatvpetGRK 898
Cdd:COG2373 1011 LTGKAGTVTVTLEASGGLT--LEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------GES 1072
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 899 DTVVKVLIVEPEGIKQEHTFSSLFcasDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIRNTQNLLHMPYGCGEQN 978
Cdd:COG2373 1073 DAREVELPVRPANPLVTRATSGVL---APGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQT 1149
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 979 MVLFAPNIYVLKyLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGdqnGEREGNTWLTAFVLKSFAQARAF- 1057
Cdd:COG2373 1150 TSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAg 1225
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1058 IFIDESHITHAFTWLSQKQKDNGcfrssgslfnnAMKGGVDDEMTLSAYITMALLESSLPATHPVvskalsclesswKTI 1137
Cdd:COG2373 1226 YAVPDDALDRALDYLRNYLRNPW-----------EIEYDDAYRLAVRAYALYVLARAGKADLGDL------------RYL 1282
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1138 EQERNASF-VYTKALMAYAFALAGNQNKRDEILKSLDEEAIKENNSIHWkrpqksrkseHHLYkpqasSAEVEMNAYVVL 1216
Cdd:COG2373 1283 YDRRKDALsPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALALA 1347
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1217 ARLTAQP-APSPEDLtlsmstIMWLTKQQNSnGGFSSTQDTVVALDALSKYgavtFSRSQKTTLVTIQSTGSfSQKFQVE 1295
Cdd:COG2373 1348 LLAELGPdAPLAPKL------ARWLAKALKS-GRWLSTQETAWALLALAAY----ARAAGASPDFTATLTLD-GKTLPLT 1415
|
1290 1300 1310
....*....|....*....|....*....|....*...
gi 568940990 1296 NSNRLLLQQVALPDI-PGDYTISVSGEGCVYAQTMLRY 1332
Cdd:COG2373 1416 GRGPLARVTLPAAELlAGPLTITNTGDGPLYYTLTLSG 1453
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1376-1466 |
2.15e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 124.22 E-value: 2.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1376 PASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTE-VSNNNVLIYLDQVTNQTLAFSFIIQQDIPVRNLQPAIVKVYDY 1454
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 568940990 1455 YETDEMAFAEYS 1466
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
449-599 |
7.09e-29 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 113.21 E-value: 7.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 449 IYLDTETssiLPCNQIHTVQAHFILKGDlgVLKELiFYYLVMAQGSIIQTGNHTHQVEpgeapvkgkfaLEIPVEFSMVP 528
Cdd:pfam07703 3 LSTDKTE---YKPGETATVTVKSPFDGT--VERDG-FTYLVLSKGQIVVVGRGGVTTS-----------FSLPVTAEMAP 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568940990 529 MAKMLIYTI---LPDGEVIADSVNFEIEKCLRNKVDLRFSTSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLL 599
Cdd:pfam07703 66 SARVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
960-1266 |
3.10e-165 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 497.87 E-value: 3.10e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 960 AIRNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNgeREG 1039
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESD--KSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1040 NTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSAYITMALLESSLPAT 1119
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1120 HPVVSKALSCLESSWKTIeqernaSFVYTKALMAYAFALAGnQNKRDEILKSLDEEAIKENNSIHWKRPQKSrkSEHHLY 1199
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRPPPS--EEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568940990 1200 KPQASSAEVEMNAYVVLARLTAQpapsPEDLTLSMSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1266
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
950-1266 |
8.16e-155 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 471.40 E-value: 8.16e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 950 FSVMGDILSSAI----RNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDG 1025
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1026 SYSAFGDqngeREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSA 1105
Cdd:pfam07678 81 SYSAFGH----SPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1106 YITMALLES-----SLPATHPVVSKALSCLESswktiEQERNASFVYTKALMAYAFALAGNQNKRDEILKSLDEEAIKEN 1180
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1181 NSIHWKRPQKSRKSEHHLYKPQASSAEVEMNAYVVLARLTaqpapsPEDLTLSMSTIMWLTKQQNSNGGFSSTQDTVVAL 1260
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYLL------LGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 568940990 1261 DALSKY 1266
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
960-1266 |
1.12e-114 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 362.09 E-value: 1.12e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 960 AIRNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNgerEG 1039
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSD---SG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1040 NTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSAYITMALLESSLPAt 1119
Cdd:cd02891 78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1120 HPVVSKALSCLESSWKtieqerNASFVYTKALMAYAFALAGNQNKRDEILKSLDEEAIKENNSIHWkrpqksrksEHHLY 1199
Cdd:cd02891 157 DASIEKALAYLETQLD------GLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHW---------SLSWP 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568940990 1200 KPQASSAEVEMNAYVVLARLtaqpapSPEDLTLSMSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1266
Cdd:cd02891 222 GDYGSSLRVEATAYALLALL------KLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
961-1266 |
2.19e-78 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 261.05 E-value: 2.19e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 961 IRNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLNETQQLTQ---KIKTKALGFLRAGYQRELNYKHKDGSYSAFGDqngeR 1037
Cdd:cd02896 2 PEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQWEKlgpERRDEALKYIRQGYQRQLSYRKPDGSYAAWKN----R 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1038 EGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGV---DDEMTLSAYITMALLEs 1114
Cdd:cd02896 78 PSSTWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQE- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1115 SLPATHPVV-------SKALSCLEsswktiEQERNASFVYTKALMAYAFALAGNQNKRDEiLKSLDEEAIKENNSIHWKR 1187
Cdd:cd02896 157 ARSICPPEVqnldqsiRKAISYLE------NQLPNLQRPYALAITAYALALADSPLSHAA-NRKLLSLAKRDGNGWYWWT 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568940990 1188 PQKSrksehHLYKPQASSAEVEMNAYVVLARLtaqpapSPEDLTLSMSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1266
Cdd:cd02896 230 IDSP-----YWPVPGPSAITVETTAYALLALL------KLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
960-1266 |
6.87e-66 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 225.51 E-value: 6.87e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 960 AIRNTQNLLHMPYG--------CGEQNMVLFAPNIYVLKYLNETQqltqkIKTKALGFLRAGYQRELNYKHKDGSYSAFG 1031
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1032 DQNgerEGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMkgGVDDEMTLSAYITMAL 1111
Cdd:cd00688 76 GND---YPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIG--GDESDVRLTAYALIAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1112 LESSLPATHPVVSKALSCLESS--WKTIEQERNASFVYTKALMAYAFALAG--NQNKRDEILKSLDEEAIKENNSIHWKR 1187
Cdd:cd00688 151 ALLGKLDPDPLIEKALDYLLSCqnYDGGFGPGGESHGYGTACAAAALALLGdlDSPDAKKALRWLLSRQRPDGGWGEGRD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1188 pqksrksehhLYKPQASSAEVEMNAYVVLARLtaqpapSPEDLTLSMSTIMWLTKQQNSNGGFSS-------TQDTVVAL 1260
Cdd:cd00688 231 ----------RTNKLSDSCYTEWAAYALLALG------KLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFAL 294
|
....*.
gi 568940990 1261 DALSKY 1266
Cdd:cd00688 295 LALSLY 300
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
740-830 |
2.54e-37 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 135.41 E-value: 2.54e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 740 TWVWDIVTVNSTGLAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFKPFFVEVSLPYSVVRGEAFMLKATVMNY 819
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 568940990 820 LPTSMQMSVQL 830
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
97-1332 |
2.18e-36 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 151.00 E-value: 2.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 97 SDEEDFLYVDIK-GPTHEFSKRK-AVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKMLRPLNELlPL-AYIEDP--K 171
Cdd:COG2373 337 RKGGDFAFLDLDdGPALDLSDFDvGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPdgK 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 172 KNRIMQWRDikTENGLKQMSFSLAAEPIQGPYKIVVHKESGEKE-EHSFTVMEFVLPRFNVDLKVPNAMSVNDEVLSVTA 250
Cdd:COG2373 416 EVRRQTLTL--NEFGGYSFSFPLPEDAPTGTWRLELYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTV 493
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 251 CGKYTYGKPVPG-HVKINV----------------------CRETETGcREVNSQLDNNGCSTQEVNITELQSKKRNYEV 307
Cdd:COG2373 494 DARYLFGAPAAGlKVEGEVtlrpartafpgypgyrfgdpdeEFEPEEL-DLGEGTLDADGKASLSLPLPDAPDAPGPLRA 572
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 308 QlfhVNATVTEEGtGLEFSRSGTTKIERiTNKLIFLKAD--SHFRHGIPFFVKVRLVDIKGDPIPNEKVFIKAQELSYTS 385
Cdd:COG2373 573 T---VEASVFESG-GRPVTRSATVPVHP-ADFYVGIRLPlfDGDPEGAPATFEVVAVDPDGKPVAGKGLKVELYREEWRY 647
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 386 ATTTDQHGLAEFSIDTTCISGSSLHIKVNHKEEDSCSYF------YCMEERHASAKHVA----YAVYSLSKSyiyLDT-- 453
Cdd:COG2373 648 VWYKSDDGGWRYESQEKEEPVAEGTLTTGADGPASLSLTpvewgrYRLEVKDPDGGLATsvrfYAGGNASWG---AERpd 724
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 454 --------------ETSSILpcnqihtVQAHFILKGdlgvlkelifyyLVMAQGS-IIQTgnHTHQVEPGEAPVkgkfal 518
Cdd:COG2373 725 rlelsldkesykpgETAKLL-------IQSPFAGRA------------LVTVERDgVLET--QWVDVKGGGTTV------ 777
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 519 EIPVEFSMVPMAkmliY---TILPDGEVIAD--------SVNFEIEKCLRnKVDLRFSTSQSL-PASQTRLQVTASPQSl 586
Cdd:COG2373 778 EIPVTEDWAPNA----YvsaTLVRPGDSTANdmparaygVAPLPVDPPAR-RLKVELTAPEKLrPGETLTVTVKVKGAA- 851
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 587 cG------LRAVDQSVLLLKPESELSP-SWIYnlpgmQQNKFVPSSRlsedqedcilysswlaekhtnlvphgtekDVYR 659
Cdd:COG2373 852 -GkaaevtLAAVDEGILNLTGYKTPDPlDFFY-----GKRALGVETR-----------------------------DLYG 896
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 660 YVedmgLTAFTNLMIKLPIicfdyGMvpisaprvefDLAFTPEiswslrttlskRPEEPPRKDpssndpltetirkyFPE 739
Cdd:COG2373 897 RL----IGAFGGAAGALRS-----GG----------DGALGRG-----------GNPKPPRKR--------------FKP 932
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 740 TWVWD-IVTVNSTGLAEVEMTVPDTITEWKAGALCLSnDTGLGlSSVVPLQAFKPFFVEVSLPYSVVRGEAFMLKATVMN 818
Cdd:COG2373 933 VALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFN 1010
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 819 YLPTSMQMSVQLEASPDFTavPVGDDQDSYCLSANGRHTSSWLVTPKSLGNVNFSVSAEAQqssepcgsevatvpetGRK 898
Cdd:COG2373 1011 LTGKAGTVTVTLEASGGLT--LEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------GES 1072
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 899 DTVVKVLIVEPEGIKQEHTFSSLFcasDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIRNTQNLLHMPYGCGEQN 978
Cdd:COG2373 1073 DAREVELPVRPANPLVTRATSGVL---APGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQT 1149
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 979 MVLFAPNIYVLKyLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGdqnGEREGNTWLTAFVLKSFAQARAF- 1057
Cdd:COG2373 1150 TSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAg 1225
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1058 IFIDESHITHAFTWLSQKQKDNGcfrssgslfnnAMKGGVDDEMTLSAYITMALLESSLPATHPVvskalsclesswKTI 1137
Cdd:COG2373 1226 YAVPDDALDRALDYLRNYLRNPW-----------EIEYDDAYRLAVRAYALYVLARAGKADLGDL------------RYL 1282
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1138 EQERNASF-VYTKALMAYAFALAGNQNKRDEILKSLDEEAIKENNSIHWkrpqksrkseHHLYkpqasSAEVEMNAYVVL 1216
Cdd:COG2373 1283 YDRRKDALsPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALALA 1347
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1217 ARLTAQP-APSPEDLtlsmstIMWLTKQQNSnGGFSSTQDTVVALDALSKYgavtFSRSQKTTLVTIQSTGSfSQKFQVE 1295
Cdd:COG2373 1348 LLAELGPdAPLAPKL------ARWLAKALKS-GRWLSTQETAWALLALAAY----ARAAGASPDFTATLTLD-GKTLPLT 1415
|
1290 1300 1310
....*....|....*....|....*....|....*...
gi 568940990 1296 NSNRLLLQQVALPDI-PGDYTISVSGEGCVYAQTMLRY 1332
Cdd:COG2373 1416 GRGPLARVTLPAAELlAGPLTITNTGDGPLYYTLTLSG 1453
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1376-1466 |
2.15e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 124.22 E-value: 2.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 1376 PASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTE-VSNNNVLIYLDQVTNQTLAFSFIIQQDIPVRNLQPAIVKVYDY 1454
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 568940990 1455 YETDEMAFAEYS 1466
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
449-599 |
7.09e-29 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 113.21 E-value: 7.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 449 IYLDTETssiLPCNQIHTVQAHFILKGDlgVLKELiFYYLVMAQGSIIQTGNHTHQVEpgeapvkgkfaLEIPVEFSMVP 528
Cdd:pfam07703 3 LSTDKTE---YKPGETATVTVKSPFDGT--VERDG-FTYLVLSKGQIVVVGRGGVTTS-----------FSLPVTAEMAP 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568940990 529 MAKMLIYTI---LPDGEVIADSVNFEIEKCLRNKVDLRFSTSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLL 599
Cdd:pfam07703 66 SARVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
223-302 |
5.93e-25 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 99.65 E-value: 5.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 223 EFVLPRFNVDLKVPNAMSVNDEVLSVTACGKYTYGKPVPGHVKINVCRETETGCRE---VNSQLDNNGCSTQEVNITELQ 299
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCfesFSKELDKDGCGSASLSTEEFQ 80
|
...
gi 568940990 300 SKK 302
Cdd:pfam17791 81 LTF 83
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
340-434 |
7.43e-25 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 100.02 E-value: 7.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 340 LIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEKVFIKAQELSYTSATTTDQHGLAEFSIDTTCiSGSSLHIKVNHKEED 419
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*
gi 568940990 420 SCSYFYCMEERHASA 434
Cdd:pfam17789 80 LCPEHQALAEMYAEA 94
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
129-221 |
5.89e-21 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 88.91 E-value: 5.89e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568940990 129 VFVQTDKPVYKPGQSVKFRVVSMDKMLRPLNELLPLAYIEDPKKNRIMQWRDIKTENGLKQMSFSLAAEPIQGPYKIVVH 208
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 568940990 209 KESGEKE-EHSFTV 221
Cdd:pfam01835 82 DGAGGSLgSGSFRV 95
|
|
| |
