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    Ephb6 Eph receptor B6 [ Mus musculus (house mouse) ]

    Gene ID: 13848, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Ephb6provided by MGI
    Official Full Name
    Eph receptor B6provided by MGI
    Primary source
    MGI:MGI:1096338
    See related
    Ensembl:ENSMUSG00000029869 AllianceGenome:MGI:1096338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mep; Cekl
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Acts upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; integumental system; intraembryonic coelom; and sensory organ. Orthologous to human EPHB6 (EPH receptor B6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 56.8), cortex adult (RPKM 24.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B2.1; 6 19.77 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (41581940..41597445)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (41603834..41620509)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene T cell receptor beta chain Neighboring gene STARR-seq mESC enhancer starr_15702 Neighboring gene STARR-seq mESC enhancer starr_15703 Neighboring gene STARR-seq mESC enhancer starr_15704 Neighboring gene T cell receptor beta, variable 31 Neighboring gene predicted gene, 27549 Neighboring gene predicted gene, 38795 Neighboring gene transient receptor potential cation channel, subfamily V, member 6 Neighboring gene predicted gene, 34642 Neighboring gene transient receptor potential cation channel, subfamily V, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The receptor tyrosine kinase EPHB6 regulates catecholamine exocytosis in adrenal gland chromaffin cells. Shi W, et al. J Biol Chem, 2020 May 29. PMID 32321761, Free PMC Article
    2. EPHB6 controls catecholamine biosynthesis by up-regulating tyrosine hydroxylase transcription in adrenal gland chromaffin cells. Shi W, et al. J Biol Chem, 2019 Apr 26. PMID 30824540, Free PMC Article
    3. EPHB6 and testosterone in concert regulate epinephrine release by adrenal gland chromaffin cells. Wang Y, et al. Sci Rep, 2018 Jan 16. PMID 29339804, Free PMC Article
    4. Acute DSS colitis alters EphB6 receptor expression in neurons of the spinal dorsal horn. King DE. Neurosci Lett, 2014 Jan 24. PMID 24309292
    5. Developmental expression of EphB6 in the thymus: lessons from EphB6 knockout mice. Shimoyama M, et al. Biochem Biophys Res Commun, 2002 Oct 18. PMID 12379224

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The receptor tyrosine kinase EPHB6 regulates catecholamine exocytosis in adrenal gland chromaffin cells.
      Title: The receptor tyrosine kinase EPHB6 regulates catecholamine exocytosis in adrenal gland chromaffin cells.
    2. findings elucidate the mechanisms by which EPHB6 modulates catecholamine (CAT) biosynthesis and identify potential therapeutic targets for diseases, such as hypertension, caused by dysfunctional CAT biosynthesis
      Title: EPHB6 controls catecholamine biosynthesis by up-regulating tyrosine hydroxylase transcription in adrenal gland chromaffin cells.
    3. using an EphB6 mouse knockout model we found that the loss of EphB6 does not initiate intestinal tumorigenesis and is not involved in the early tumor progression through the adenoma-to-carcinoma transition.
      Title: Loss of the EPH receptor B6 contributes to colorectal cancer metastasis.
    4. Colitis significantly downregulates Ephb6 expression in the neurons of the spinal dorsal horn.
      Title: Acute DSS colitis alters EphB6 receptor expression in neurons of the spinal dorsal horn.
    5. Ephs and Efns, in concert with testosterone, play a critical role in regulating small artery contractility and blood pressure.
      Title: Receptor tyrosine kinase Ephb6 regulates vascular smooth muscle contractility and modulates blood pressure in concert with sex hormones.
    6. T-cell development in EphB6 knockout mice
      Title: Developmental expression of EphB6 in the thymus: lessons from EphB6 knockout mice.
    7. EphB6 is pivotal in T cell function as shown by its null mutation
      Title: EphB6-null mutation results in compromised T cell function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell costimulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within type IV hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-B receptor 6
    Names
    chicken eph/elk receptor-like protein
    ephrin type A receptor
    tyrosine-protein kinase-defective receptor EPH-6
    NP_001139823.1
    NP_031706.3
    XP_036021701.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146351.2 → NP_001139823.1  ephrin type-B receptor 6 precursor

      See identical proteins and their annotated locations for NP_001139823.1

      Status: VALIDATED

      Source sequence(s)
      AC117678
      Consensus CDS
      CCDS20051.1
      UniProtKB/Swiss-Prot
      O08644, Q3TQ77, Q8BN76, Q8K0A9
      UniProtKB/TrEMBL
      A2JY28
      Related
      ENSMUSP00000110380.3, ENSMUST00000114732.3
      Conserved Domains (8) summary
      cd09555
      Location:938 → 1006
      SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
      smart00454
      Location:939 → 1005
      SAM; Sterile alpha motif
      cd10475
      Location:34 → 226
      EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
      cd00063
      Location:481 → 572
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07699
      Location:305 → 340
      GCC2_GCC3; GCC2 and GCC3
      pfam07714
      Location:663 → 908
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:605 → 658
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl21453
      Location:658 → 912
      PKc_like; Protein Kinases, catalytic domain

    2. NM_007680.5 → NP_031706.3  ephrin type-B receptor 6 precursor

      See identical proteins and their annotated locations for NP_031706.3

      Status: VALIDATED

      Source sequence(s)
      AC117678
      Consensus CDS
      CCDS20051.1
      UniProtKB/Swiss-Prot
      O08644, Q3TQ77, Q8BN76, Q8K0A9
      UniProtKB/TrEMBL
      A2JY28
      Conserved Domains (8) summary
      cd09555
      Location:938 → 1006
      SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
      smart00454
      Location:939 → 1005
      SAM; Sterile alpha motif
      cd10475
      Location:34 → 226
      EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
      cd00063
      Location:481 → 572
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07699
      Location:305 → 340
      GCC2_GCC3; GCC2 and GCC3
      pfam07714
      Location:663 → 908
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:605 → 658
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl21453
      Location:658 → 912
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_166495.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117678

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      41581940..41597445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165808.1 → XP_036021701.1  ephrin type-B receptor 6 isoform X3

      UniProtKB/TrEMBL
      A2JY28
      Conserved Domains (6) summary
      cd09555
      Location:882 → 950
      SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
      cd10475
      Location:34 → 226
      EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
      pfam00041
      Location:482 → 564
      fn3; Fibronectin type III domain
      pfam07699
      Location:305 → 340
      Ephrin_rec_like; Putative ephrin-receptor like
      pfam14575
      Location:554 → 604
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl21453
      Location:602 → 856
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003956161.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08644.4 GenPept UniProtKB/Swiss-Prot:O08644

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