Conserved Protein Domain Family
EphA2_TM
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pfam14575: EphA2_TM (this model, PSSM-Id:405290 is obsolete and has been replaced by 464211)
Ephrin type-A receptor 2 transmembrane domain
Epha2_TM represents the left-handed dimer transmembrane domain of of EphA2 receptor. This domain oligomerizes and is important for the active signalling process.
Links
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Statistics
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PSSM-Id: 405290
Aligned: 138 rows
Threshold Bit Score: 42.3141
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002711965  544 TAVVGVVLVLVVIIIAILCL-RKQSSGRDA-------------------------------------------------- 572  rabbit
XP_006094814  546 AIIFGMLLGMGLLLGIFVFRsRKRRQLQQQrqld---------------------------------------------- 579  little brown bat
XP_008117625  548 CIIFGILLFIGLVGGLIILRrRQAHRRARPcq------------------------------------------------ 579  green anole
O61460        561 lIIIALILIVIAVALCMIVVqKKSKNRKQMsdldvldtykqdsmtpdyhttsrhhhhqgnlpatlheqlrsttklnapli 640  Caenorhabditi...
XP_011613389  193 qdlGACMSILA-----VRVFyKKCPSVVQNfa------------------------------------------------ 219  torafugu
6_pfamImport    1 ---------------------KCSCSA----------------------------------------------------- 6   
PIC43981      391 liiialilvviaialCMIVVqKKTKNRKQMsdldvldtykqdsmtpdyhttsrhhhhqgnlpanlheqlrsttklnapli 470  Caenorhabditi...
XP_019473507  277 SIIFGVLLFIGLLLGILFFRrKKTHRRQARpdy----------------------------------------------- 309  turkey
XP_016151925  565 SIIFGVFLFIALILGLFMFWrKRARRRHARpdy----------------------------------------------- 597  collared flyc...
XP_021404871  537 SIIFGVLLFIGLVVGFLMFRrKRARRRHARpdy----------------------------------------------- 569  Bengalese finch

XP_002711965  573 --------------EYSDKHGQYlighgTKVYIDP-----FTYEDPNEAVREFAKEIDV 612  rabbit
XP_006094814  580 -----------cvtNVNRGDKQR-----LKPYVDLlaepmTAYEDPARGALDFTQELDP 622  little brown bat
XP_008117625  580 ------------khSSYNRDDIW-----LKPYVDL-----QPYEDPSRGVLEFTKELDP 616  green anole
O61460        641 psfgspisqpppyyGGVHPNSGK-----YKTYVDP-----TTYEDPYQALIEFTFDIsp 689  Caenorhabditis elegans
XP_011613389  220 ------------yfPETLTGAEStslviargscisnaeevdvpiklycngdgewmvpig 266  torafugu
6_pfamImport    7 -----------------GYEEGH------------------------------------ 12  
PIC43981      471 psfgspisqpppyyGGVHTNSGK-----YKTYVDP-----TTYEDPYQALIEFTFDIsp 519  Caenorhabditis nigoni
XP_019473507  310 ------------stSGFDREKVW-----LKPYVDL-----QPYDDPSRGVLEFTKELDV 346  turkey
XP_016151925  598 ------------stSGFEREKVW-----LKPYVDL-----QPYDDPSRGVLEFTKELDV 634  collared flycatcher
XP_021404871  570 -----------ntsGFER-EKVW-----LKPYVDL-----QPYDDPSRGVLEFTKELDV 606  Bengalese finch
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