Hyou1 hypoxia up-regulated 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hyou1provided by MGI
Official Full Name: hypoxia up-regulated 1provided by MGI
Primary source: MGI:MGI:108030
See related: Ensembl:ENSMUSG00000032115 AllianceGenome:MGI:108030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cab140; Grp170; Orp150; CBP-140
Summary: Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway and response to ischemia. Part of endoplasmic reticulum chaperone complex. Is expressed in embryo and tail. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 39.8), placenta adult (RPKM 37.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44290840..44303662)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44379490..44392369)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function.
Title: Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function.
FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
Title: FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice.
Title: The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice.
Coordination of Grp1 recruitment mechanisms by its phosphorylation.
Title: Coordination of Grp1 recruitment mechanisms by its phosphorylation.
The protein but not the mRNA level of ORP150, a nucleotide exchange factor which can substitute for SIL1, was increased in the cerebellum of GSK2606414-treated woozy mice, suggesting that translational recovery promoted the synthesis of this alternative BiP co-factor
Title: PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome.
The relative increase in ORP150 mRNA observed in hypoxia, compared with normoxia, may support its cytoprotective role in oxygendeprived conditions
Title: Hypoxia mediates osteocyte ORP150 expression and cell death in vitro.
Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins.
Title: The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s.
These results suggest that although ORP150 is protective against bleomycin-induced lung injury, this protein could stimulate bleomycin-induced pulmonary fibrosis by increasing pulmonary levels of TGF-beta1 and myofibroblasts.
Title: Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice.
Results reveal a previously unrecognized attribute of Grp170 as a superior DNA-binding chaperone capable of amplifying TLR9 activation on pathogen recognition.
Title: Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity.
AICAR infusion enhanced ORP150 expression, resulting in the marked amelioration of hepatic ER stress and apoptosis
Title: Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1)
Targeted (1) 1 citation
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ischemia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ischemia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
part_of endoplasmic reticulum chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of endoplasmic reticulum chaperone complex	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hypoxia up-regulated protein 1

Names: 140 kDa Ca(2+)-binding protein; 150-kDa oxygen regulated protein; 170 kDa glucose regulated protein GRP170; GRP-170; calcium binding protein 140; calcium binding protein, 140 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411630.1 → NP_001398559.1 hypoxia up-regulated protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC122428
NM_001411631.1 → NP_001398560.1 hypoxia up-regulated protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC122428
NM_021395.5 → NP_067370.3 hypoxia up-regulated protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_067370.3

Status: VALIDATED

Source sequence(s)

AC122428

Consensus CDS

CCDS23107.1

UniProtKB/Swiss-Prot

Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6

Related

ENSMUSP00000068594.7, ENSMUST00000066601.13

Conserved Domains (3) summary

cd10230
Location:36 → 424

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins

PHA03169
Location:586 → 691

PHA03169; hypothetical protein; Provisional

COG5271
Location:554 → 767

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

44290840..44303662

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509960.4 → XP_006510023.1 hypoxia up-regulated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006510023.1

UniProtKB/Swiss-Prot

Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6

Related

ENSMUSP00000123700.2, ENSMUST00000161318.8

Conserved Domains (3) summary

cd10230
Location:36 → 424

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins

PHA03169
Location:586 → 691

PHA03169; hypothetical protein; Provisional

COG5271
Location:554 → 767

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
XM_006509961.4 → XP_006510024.1 hypoxia up-regulated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006510024.1

UniProtKB/Swiss-Prot

Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6

Conserved Domains (3) summary

cd10230
Location:36 → 424

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins

PHA03169
Location:586 → 691

PHA03169; hypothetical protein; Provisional

COG5271
Location:554 → 767

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
XM_006509959.4 → XP_006510022.1 hypoxia up-regulated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006510022.1

UniProtKB/Swiss-Prot

Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6

Related

ENSMUSP00000125594.2, ENSMUST00000160902.8

Conserved Domains (3) summary

cd10230
Location:36 → 424

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins

PHA03169
Location:586 → 691

PHA03169; hypothetical protein; Provisional

COG5271
Location:554 → 767

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
XM_006509962.4 → XP_006510025.1 hypoxia up-regulated protein 1 isoform X2

Conserved Domains (2) summary

cd10230
Location:36 → 424

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins

PHA00666
Location:597 → 760

PHA00666; putative protease