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    Adam33 a disintegrin and metallopeptidase domain 33 [ Mus musculus (house mouse) ]

    Gene ID: 110751, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Adam33provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 33provided by MGI
    Primary source
    MGI:MGI:1341813
    See related
    Ensembl:ENSMUSG00000027318 AllianceGenome:MGI:1341813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adaml
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is widely expressed, most highly in the adult brain, heart, kidney, lung and testis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
    Expression
    Biased expression in bladder adult (RPKM 51.9), limb E14.5 (RPKM 19.8) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F1; 2 63.26 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130892739..130905734, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131050819..131063814, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39937 Neighboring gene microRNA 6973b Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 4 Neighboring gene sialic acid binding Ig-like lectin 1, sialoadhesin Neighboring gene STARR-seq mESC enhancer starr_05699 Neighboring gene predicted gene, 30378

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Chen C, et al. Mol Cell Biol, 2006 Sep. PMID 16943435, Free PMC Article
    2. Mouse ADAM33: two splice variants differ in protein maturation and localization. Umland SP, et al. Am J Respir Cell Mol Biol, 2004 Apr. PMID 12972401
    3. Identification and preliminary characterization of mouse Adam33. Gunn TM, et al. BMC Genet, 2002. PMID 11897009, Free PMC Article
    4. Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy. Haitchi HM, et al. J Allergy Clin Immunol, 2009 Sep. PMID 19665773
    5. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Van Eerdewegh P, et al. Nature, 2002 Jul 25. PMID 12110844

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adam33/Adam33 shows 2 significant increments in expression during lung morphogenesis, suggesting important developmental regulation.
      Title: Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.
    2. ADAM33 is not essential for growth or reproduction in the mouse and does not modulate baseline or allergen-induced airway responsiveness.
      Title: ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.
    3. The mouse and human predicted proteins consisted of 797 and 813 amino acids, respectively, and they shared 70% homology of the entire amino acid sequence.
      Title: Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity.
    4. Identification and preliminary characterization of mouse Adam33.
      Title: Identification and preliminary characterization of mouse Adam33.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cytokine production NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 33
    Names
    a disintegrin and metalloprotease domain 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163529.2 → NP_001157001.1  disintegrin and metalloproteinase domain-containing protein 33 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001157001.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
      Source sequence(s)
      AL833771, AW048228, BC138139
      Consensus CDS
      CCDS50716.1
      UniProtKB/TrEMBL
      A2AP51, Q6TYZ0
      Related
      ENSMUSP00000052486.4, ENSMUST00000052104.10
      Conserved Domains (5) summary
      smart00050
      Location:427 → 501
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:503 → 644
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:211 → 408
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:211 → 408
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:57 → 165
      Pep_M12B_propep; Reprolysin family propeptide

    2. NM_033615.3 → NP_291093.2  disintegrin and metalloproteinase domain-containing protein 33 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_291093.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL833771, AW048228, BC138139
      Consensus CDS
      CCDS16753.1
      UniProtKB/Swiss-Prot
      Q8R5G5, Q923W9
      UniProtKB/TrEMBL
      Q6TYY9
      Related
      ENSMUSP00000105861.3, ENSMUST00000110232.9
      Conserved Domains (5) summary
      smart00050
      Location:427 → 501
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:503 → 645
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:211 → 408
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:211 → 408
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:57 → 165
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. NR_136922.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL833771, AW048228, BC138139

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130892739..130905734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498576.3 → XP_006498639.2  disintegrin and metalloproteinase domain-containing protein 33 isoform X1

      UniProtKB/TrEMBL
      Q6TYY9
      Conserved Domains (4) summary
      smart00050
      Location:414 → 488
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:490 → 632
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:211 → 395
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01562
      Location:39 → 168
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_011239248.2 → XP_011237550.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

      See identical proteins and their annotated locations for XP_011237550.1

      UniProtKB/TrEMBL
      Q6TYY9
      Conserved Domains (3) summary
      smart00050
      Location:291 → 365
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:367 → 509
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:75 → 272
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

    3. XM_011239250.4 → XP_011237552.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

      See identical proteins and their annotated locations for XP_011237552.1

      UniProtKB/TrEMBL
      Q6TYY9
      Conserved Domains (3) summary
      smart00050
      Location:291 → 365
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:367 → 509
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:75 → 272
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

    4. XM_011239251.1 → XP_011237553.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

      See identical proteins and their annotated locations for XP_011237553.1

      UniProtKB/TrEMBL
      Q6TYY9
      Related
      ENSMUSP00000122608.2, ENSMUST00000135149.8
      Conserved Domains (3) summary
      smart00050
      Location:291 → 365
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:367 → 509
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:75 → 272
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

    5. XM_011239249.1 → XP_011237551.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

      See identical proteins and their annotated locations for XP_011237551.1

      UniProtKB/TrEMBL
      Q6TYY9
      Conserved Domains (3) summary
      smart00050
      Location:291 → 365
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:367 → 509
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:75 → 272
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

    6. XM_011239252.4 → XP_011237554.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X3

      UniProtKB/TrEMBL
      Q6TYZ0
      Conserved Domains (4) summary
      smart00050
      Location:427 → 501
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:503 → 637
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:211 → 408
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01562
      Location:39 → 168
      Pep_M12B_propep; Reprolysin family propeptide

    7. XM_011239255.3 → XP_011237557.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X4

      See identical proteins and their annotated locations for XP_011237557.1

      Conserved Domains (2) summary
      cd04269
      Location:211 → 361
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01562
      Location:39 → 168
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. XR_001780409.2 RNA Sequence

    2. XR_004937534.1 RNA Sequence

    3. XR_001780411.3 RNA Sequence

    4. XR_004937535.1 RNA Sequence

      Related
      ENSMUST00000132436.8

    5. XR_866209.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923W9.3 GenPept UniProtKB/Swiss-Prot:Q923W9

    Gene LinkOut

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