Btaf1 B-TFIID TATA-box binding protein associated factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Btaf1provided by MGI
Official Full Name: B-TFIID TATA-box binding protein associated factor 1provided by MGI
Primary source: MGI:MGI:2147538
See related: Ensembl:ENSMUSG00000040565 AllianceGenome:MGI:2147538
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TAF170; E430027O22Rik
Summary: Predicted to enable ATP-dependent activity, acting on DNA; DNA binding activity; and transcription coregulator activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of chromatin binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system. Orthologous to human BTAF1 (B-TFIID TATA-box binding protein associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 6.3), liver E14 (RPKM 5.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C2; 19 32.02 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (36903479..36991457)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (36926079..37014057)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mot1, Ino80 chromatin remodeling complex (Ino80C), and NC2 co-localize on chromatin and coordinately suppress pervasive transcription in murine embryonic stem cells.
Title: Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals.
An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability
Title: An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Chemically induced (ENU) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI414500 (e-PCR)
- UniSTS:160828

UniSTS:237929 (e-PCR)
- UniSTS:237929

AI447930 (e-PCR)
- UniSTS:181229

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP-dependent activity, acting on DNA	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of chromatin binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TATA-binding protein-associated factor 172

Names: BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, (Mot1 homolog, S. cerevisiae); TBP-associated factor 170

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080706.1 → NP_001074175.1 TATA-binding protein-associated factor 172

Status: PROVISIONAL

Source sequence(s)

AC118931

Consensus CDS

CCDS37969.1

UniProtKB/TrEMBL

A0ZVB6, E9QAE3

Related

ENSMUSP00000097093.4, ENSMUST00000099494.4

Conserved Domains (6) summary

cd00046
Location:1285 → 1434

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:1268 → 1584

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1643 → 1743

Helicase_C; Helicase conserved C-terminal domain

pfam12054
Location:585 → 1050

DUF3535; Domain of unknown function (DUF3535)

pfam13513
Location:402 → 453

HEAT_EZ; HEAT-like repeat

sd00044
Location:351 → 376

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

36903479..36991457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161373.1 → XP_036017266.1 TATA-binding protein-associated factor 172 isoform X1

UniProtKB/TrEMBL

A0ZVB6

Conserved Domains (4) summary

COG0553
Location:1073 → 1645

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

sd00044
Location:196 → 221

HEAT; HEAT repeat [structural motif]

cd17999
Location:1110 → 1347

DEXHc_Mot1; DEXH-box helicase domain of Mot1

pfam12054
Location:430 → 895

DUF3535; Domain of unknown function (DUF3535)
XM_006526561.5 → XP_006526624.1 TATA-binding protein-associated factor 172 isoform X2

UniProtKB/TrEMBL

A0ZVB6

Conserved Domains (4) summary

COG0553
Location:1026 → 1598

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

sd00044
Location:149 → 174

HEAT; HEAT repeat [structural motif]

cd17999
Location:1063 → 1300

DEXHc_Mot1; DEXH-box helicase domain of Mot1

pfam12054
Location:383 → 848

DUF3535; Domain of unknown function (DUF3535)
XM_030250684.2 → XP_030106544.1 TATA-binding protein-associated factor 172 isoform X3

UniProtKB/TrEMBL

Q52KH4

Conserved Domains (4) summary

COG0553
Location:456 → 1028

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

sd00044
Location:335 → 363

HEAT; HEAT repeat [structural motif]

cd17999
Location:493 → 730

DEXHc_Mot1; DEXH-box helicase domain of Mot1

pfam12054
Location:1 → 278

DUF3535; Domain of unknown function (DUF3535)
XM_017318039.3 → XP_017173528.1 TATA-binding protein-associated factor 172 isoform X3

UniProtKB/TrEMBL

Q52KH4

Conserved Domains (4) summary

COG0553
Location:456 → 1028

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

sd00044
Location:335 → 363

HEAT; HEAT repeat [structural motif]

cd17999
Location:493 → 730

DEXHc_Mot1; DEXH-box helicase domain of Mot1

pfam12054
Location:1 → 278

DUF3535; Domain of unknown function (DUF3535)