Rcor2 REST corepressor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcor2provided by MGI
Official Full Name: REST corepressor 2provided by MGI
Primary source: MGI:MGI:1859854
See related: Ensembl:ENSMUSG00000024968 AllianceGenome:MGI:1859854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1A13; Rcor; Rcor1; CoREST
Summary: Enables enzyme binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; musculoskeletal system; and retina. Orthologous to human RCOR2 (REST corepressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 58.1), CNS E14 (RPKM 45.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.32 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (7244759..7252590)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (7267394..7275225)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The studies have identified members of the CoREST repression complex as key regulators of HIV latency in microglia.
Title: HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
An INSM1/RCOR1/2 complex controls the balance of proliferation and differentiation during brain development.
Title: REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.
Rcor2, a co-repressor of LSD1, controls neurogenesis in the developing mouse brain.
Title: LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain.
CoREST1 promotes tumorigenesis in a breast cancer model at least in part through regulation of gene expression patterns in tumor cells.
Title: CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.
p120-catenin regulates REST and CoREST and modulates mouse embryonic stem cell differentiation.
Title: p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation.
miR-22 and miR-124 are expressed in the cortical wall where they target components of the CoREST/REST transcriptional repressor complex, thereby regulating doublecortin transcription in migrating neurons.
Title: MicroRNA targeting of CoREST controls polarization of migrating cortical neurons.
The results of this study suggested that Rcor2 downregulation in astrocytes induces inflammation.
Title: Rcor2 underexpression in senescent mice: a target for inflammaging?
In mature erythroid cells, a strong upsurge in Rcor3 and a sharp decline in Rcor1 levels counteract LSD1/Rcor1/2-mediated differentiation.
Title: Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation.
Knockdown of kdm1a or its partner REST corepressor 2 (rcor2) in 3T3-L1 preadipocytes results in increased expression of inflammatory cytokines and chemokines by these cells.
Title: Histone demethylase KDM1A represses inflammatory gene expression in preadipocytes.
The loss of CoREST function perturbs the dynamics of neuronal precursor cell populations, transiently increasing the fraction of cells remaining in progenitor states.
Title: CoREST/LSD1 control the development of pyramidal cortical neurons.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW122124 (e-PCR)
- UniSTS:186143

AU024026 (e-PCR)
- UniSTS:181185

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: REST corepressor 2

Names: RE1-silencing transcription factor (REST) co-repressor 1; REST co-repressor 2; co-repressor of Rest

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320554.1 → NP_001307483.1 REST corepressor 2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC055719, CJ165194

Consensus CDS

CCDS29522.2

UniProtKB/Swiss-Prot

Q8C796, Q9JMK4

UniProtKB/TrEMBL

A0A0R4J1I0

Related

ENSMUSP00000063335.5, ENSMUST00000066646.12

Conserved Domains (4) summary

smart00717
Location:331 → 376

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:331 → 374

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:46 → 98

ELM2; ELM2 domain

cl21498
Location:134 → 178

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_054048.4 → NP_473389.2 REST corepressor 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK052295, BC055719, BY198423

Consensus CDS

CCDS29522.2

UniProtKB/Swiss-Prot

Q8C796, Q9JMK4

UniProtKB/TrEMBL

A0A0R4J1I0

Related

ENSMUSP00000108996.3, ENSMUST00000113369.3

Conserved Domains (4) summary

smart00717
Location:331 → 376

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:331 → 374

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:46 → 98

ELM2; ELM2 domain

cl21498
Location:134 → 178

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

7244759..7252590

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526551.3 → XP_006526614.1 REST corepressor 2 isoform X1

UniProtKB/TrEMBL

A0A0R4J1I0

Conserved Domains (4) summary

PRK12323
Location:399 → 531

PRK12323; DNA polymerase III subunit gamma/tau

pfam00249
Location:340 → 383

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:55 → 107

ELM2; ELM2 domain

cl21498
Location:143 → 187

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_030250677.1 → XP_030106537.1 REST corepressor 2 isoform X2

Conserved Domains (2) summary

PRK12323
Location:216 → 348

PRK12323; DNA polymerase III subunit gamma/tau

pfam00249
Location:157 → 200

Myb_DNA-binding; Myb-like DNA-binding domain