Slamf9 SLAM family member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slamf9provided by MGI
Official Full Name: SLAM family member 9provided by MGI
Primary source: MGI:MGI:1923692
See related: Ensembl:ENSMUSG00000026548 AllianceGenome:MGI:1923692
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd2f10; SF2001; CD2F-10; CD84-H1; 2310026I04Rik
Summary: Acts upstream of or within defense response to bacterium; plasmacytoid dendritic cell chemotaxis; and plasmacytoid dendritic cell differentiation. Located in cell surface. Is expressed in heart ventricle; lung; and pituitary gland. Orthologous to human SLAMF9 (SLAM family member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 7.7), mammary gland adult (RPKM 7.1) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.85 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (172302927..172305976)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172458569..172478421)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages.
Title: Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages.
SLAMF9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection.
Title: Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection.
These results suggest the crucial role of SLAMF9 in plasmacytoid dendritic cell differentiation, homeostasis, and function in the steady state and during experimental autoimmune encephalomyelitis.
Title: SLAMF9 regulates pDC homeostasis and function in health and disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemokine (C-X-C motif) ligand 9 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within granulocyte macrophage colony-stimulating factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasmacytoid dendritic cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasmacytoid dendritic cell cytokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within plasmacytoid dendritic cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasmacytoid dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SLAM family member 9

Names: CD2 antigen family, member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029612.4 → NP_083888.3 SLAM family member 9 precursor

See identical proteins and their annotated locations for NP_083888.3

Status: VALIDATED

Source sequence(s)

AI120415, AK009505, BE447476

Consensus CDS

CCDS15514.1

UniProtKB/Swiss-Prot

Q8BTK0, Q8VE93, Q9D780

UniProtKB/TrEMBL

A0A0R4J072, Q18PH6

Related

ENSMUSP00000027830.5, ENSMUST00000027830.5

Conserved Domains (1) summary

cd16842
Location:30 → 128

Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family