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Conserved domains on  [gi|176866315|ref|NP_083888|]
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SLAM family member 9 precursor [Mus musculus]

Protein Classification

Ig_SLAM-like_N and Ig domain-containing protein( domain architecture ID 11617247)

Ig_SLAM-like_N and Ig domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 27-128 1.40e-33

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 118.19  E-value: 1.40e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315  27 EVVGVLQESINLSLEIPSNEEIKHIDWLFQNNIAIVKPGKKGQPAVIMaVDPRYRGRVSISESSYSLHISNLTWEDSGLY 106
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAPEIII-TDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 176866315 107 NAQVNLKTSESHITKSYHLRVY 128
Cdd:cd16842   81 RARINTKNSRVTITKEFTLHIY 102
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 133-209 4.11e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05740:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 89  Bit Score: 35.83  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315 133 KPHITVNSNISEEGVCNISLTCSIEraGMDVTYIW------LSSQDSTNTSHEGSVLS-TSWRPGDKAPsYTCRVSNPIS 205
Cdd:cd05740    1 KPFISSNNSNPVEDKDAVTLTCEPE--TQNTSYLWwfngqsLPVTPRLTLSNGNRTLTlLNVTREDAGA-YQCEISNPVS 77


                 ....
gi 176866315 206 NISS 209
Cdd:cd05740   78 ANRS 81
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 27-128 1.40e-33

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 118.19  E-value: 1.40e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315  27 EVVGVLQESINLSLEIPSNEEIKHIDWLFQNNIAIVKPGKKGQPAVIMaVDPRYRGRVSISESSYSLHISNLTWEDSGLY 106
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAPEIII-TDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 176866315 107 NAQVNLKTSESHITKSYHLRVY 128
Cdd:cd16842   81 RARINTKNSRVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-128 1.69e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.78  E-value: 1.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315   23 EDPEEVVGVLQESINLSLEIPSNEEIKH--IDWLFQnniaivKPGKKGQPAVIMAV--------DPRYRGRVSISESSYS 92
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEAStsVYWYRQ------PPGKGPTFLIAYYSngseegvkKGRFSGRGDPSNGDGS 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 176866315   93 LHISNLTWEDSGLYNAQVNlKTSESHITKSYHLRVY 128
Cdd:pfam07686  75 LTIQNLTLSDSGTYTCAVI-PSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-127 5.55e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 5.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315    25 PEEVVGVLQESINLSLEIPSNEEIkHIDWLFQNNIAIVKPGkkgqpavimavdpryRGRVSISESSYSLHISNLTWEDSG 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPP-EVTWYKQGGKLLAESG---------------RFSVSRSGSTSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|...
gi 176866315   105 LYNAQVnlKTSESHITKSYHLRV 127
Cdd:smart00410  65 TYTCAA--TNSSGSASSGTTLTV 85
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 133-209 4.11e-03

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 35.83  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315 133 KPHITVNSNISEEGVCNISLTCSIEraGMDVTYIW------LSSQDSTNTSHEGSVLS-TSWRPGDKAPsYTCRVSNPIS 205
Cdd:cd05740    1 KPFISSNNSNPVEDKDAVTLTCEPE--TQNTSYLWwfngqsLPVTPRLTLSNGNRTLTlLNVTREDAGA-YQCEISNPVS 77


                 ....
gi 176866315 206 NISS 209
Cdd:cd05740   78 ANRS 81
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 27-128 1.40e-33

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 118.19  E-value: 1.40e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315  27 EVVGVLQESINLSLEIPSNEEIKHIDWLFQNNIAIVKPGKKGQPAVIMaVDPRYRGRVSISESSYSLHISNLTWEDSGLY 106
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAPEIII-TDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 176866315 107 NAQVNLKTSESHITKSYHLRVY 128
Cdd:cd16842   81 RARINTKNSRVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-128 1.69e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.78  E-value: 1.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315   23 EDPEEVVGVLQESINLSLEIPSNEEIKH--IDWLFQnniaivKPGKKGQPAVIMAV--------DPRYRGRVSISESSYS 92
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEAStsVYWYRQ------PPGKGPTFLIAYYSngseegvkKGRFSGRGDPSNGDGS 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 176866315   93 LHISNLTWEDSGLYNAQVNlKTSESHITKSYHLRVY 128
Cdd:pfam07686  75 LTIQNLTLSDSGTYTCAVI-PSGEGVFGKGTRLTVL 109
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 26-128 3.82e-07

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 47.34  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315  26 EEVVGVLQESINLSLEIpSNEEIKHIDWLFqNNIAIVKPGKKGQPAVImavdPRYRGRVSISESSYSLHISNLTWEDSGL 105
Cdd:cd05775    3 GEVYGALGGNVTLTISS-LQDDIDEIKWKK-TKDKIVEWENNIGPTYF----GSFKDRVLLDKESGSLTIKNLTKEDSGT 76

                         90       100
                 ....*....|....*....|...
gi 176866315 106 YNAQVnLKTSESHITKSYHLRVY 128
Cdd:cd05775   77 YELEI-TSTNGKVLSSKFTLEVL 98
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-127 5.55e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 5.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315    25 PEEVVGVLQESINLSLEIPSNEEIkHIDWLFQNNIAIVKPGkkgqpavimavdpryRGRVSISESSYSLHISNLTWEDSG 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPP-EVTWYKQGGKLLAESG---------------RFSVSRSGSTSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|...
gi 176866315   105 LYNAQVnlKTSESHITKSYHLRV 127
Cdd:smart00410  65 TYTCAA--TNSSGSASSGTTLTV 85
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 25-106 8.07e-05

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 41.28  E-value: 8.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315  25 PEEVVGVLQESINL--SLEIPSNEEIKHIDWLF-----QNNIAIVKPgKKGqpaviMAVDPRYRGRV-----SISESSYS 92
Cdd:cd05718    6 PTEVTGFLGGSVTLpcSLTSPGTTKITQVTWMKigagsSQNVAVFHP-QYG-----PSVPNPYAERVeflaaRLGLRNAT 79

                         90
                 ....*....|....
gi 176866315  93 LHISNLTWEDSGLY 106
Cdd:cd05718   80 LRIRNLRVEDEGNY 93
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 23-124 1.91e-04

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 40.20  E-value: 1.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315  23 EDPEEVVGVLQESINLSLE-IPSNEEIKH-IDWLFQNNiaivkpgkkGQPAVIMAVD--------PRYRGRVSISESS-- 90
Cdd:cd16089    4 EGPESITGPWKGSVNLPCTyVPEEGYTQVlVKWLVQRD---------SDPVTIFLRDssgdhiqqAKYRGRLEVSKDTpg 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 176866315  91 -YSLHISNLTWEDSGLYNAQVNLKTSESHITKSYH 124
Cdd:cd16089   75 dVSLQLDTLEMDDRGHYTCQVTWQTPDGNLIVREK 109
IGv smart00406
Immunoglobulin V-Type;
50-106 1.01e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.36  E-value: 1.01e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 176866315    50 HIDWLFQnniaivKPGKkgQPAVIMAV--------DPRYRGRVSI----SESSYSLHISNLTWEDSGLY 106
Cdd:smart00406  17 YVSWVRQ------PPGK--GLEWLGYIgsngssyyQESYKGRFTIskdtSKNDVSLTISNLRVEDTGTY 77
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 31-106 2.51e-03

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 36.94  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315  31 VLQESINLSLEIPSNEEIKHIDW------LFQNNIAI-VKPGKKgqpavimaVDPRYRGRVSISES---SYSLHISNLTW 100
Cdd:cd05846   11 VLGGNATLSCNLTLPEEVLQVTWqkikasSPENIVTYsKKYGVK--------IQPSYVRRISFTSSglnSTSITIWNVTL 82


                 ....*.
gi 176866315 101 EDSGLY 106
Cdd:cd05846   83 EDEGCY 88
IgV_1_DNAM-1_like cd05889
First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; ...
 31-106 2.59e-03

First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226). DNAM-1 is a transmembrane protein having two Ig-like domains. It is an adhesion molecule which plays a part in tumor-directed cytotoxicity and adhesion in natural killer (NK) cells and T lymphocytes. It has been shown to regulate the NK cell killing of several tumor types, including myeloma cells and ovarian carcinoma cells. DNAM-1 interacts specifically with poliovirus receptor (PVR; CD155) and nectin -2 (CD211), other members of the Ig superfamily. DNAM-1 is expressed in most peripheral T cells, NK cells, monocytes and a subset of B lymphocytes.


Pssm-ID: 409472  Cd Length: 111  Bit Score: 36.76  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315  31 VLQESINLSLEIPSNEEIKHIDWL----FQNNIAIVKPGKKgqpaviMAVDPRYRGRVSISESSY-----SLHISNLTWE 101
Cdd:cd05889   12 PLSENMSLECVYPSTGILTQVEWTkiggQKDNIAVYHPTHG------MHIRKPYAGRVYFLNSTMasnnmSLSFRNASED 85


                 ....*
gi 176866315 102 DSGLY 106
Cdd:cd05889   86 DVGYY 90
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 133-209 4.11e-03

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 35.83  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315 133 KPHITVNSNISEEGVCNISLTCSIEraGMDVTYIW------LSSQDSTNTSHEGSVLS-TSWRPGDKAPsYTCRVSNPIS 205
Cdd:cd05740    1 KPFISSNNSNPVEDKDAVTLTCEPE--TQNTSYLWwfngqsLPVTPRLTLSNGNRTLTlLNVTREDAGA-YQCEISNPVS 77


                 ....
gi 176866315 206 NISS 209
Cdd:cd05740   78 ANRS 81
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 34-106 4.90e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 36.16  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 176866315  34 ESINLSLEIPSNEEIKHIDWLFQnniaivKPGK---------KGQPAVIMAVDPRYRGRVSiSESSYSLHISNLTWEDSG 104
Cdd:cd00099   14 ESVTLSCEVSSSFSSTYIYWYRQ------KPGQgpefliylsSSKGKTKGGVPGRFSGSRD-GTSSFSLTISNLQPEDSG 86


                 ..
gi 176866315 105 LY 106
Cdd:cd00099   87 TY 88
IgV_CEACAM_D1 cd05774
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 78-127 8.58e-03

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.


Pssm-ID: 409430  Cd Length: 105  Bit Score: 35.32  E-value: 8.58e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 176866315  78 PRYRGRVSISeSSYSLHISNLTWEDSGLYNAQV---NLKTSESHItksyHLRV 127
Cdd:cd05774   58 PAYSGRETIY-PNGSLLIQNVTQKDTGFYTLQTitaDLQTEQASV----HLQV 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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