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kdm2ab lysine (K)-specific demethylase 2Ab [ Danio rerio (zebrafish) ]

Gene ID: 799441, updated on 27-Mar-2024

Summary

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Official Symbol
kdm2abprovided by ZNC
Official Full Name
lysine (K)-specific demethylase 2Abprovided by ZNC
Primary source
ZFIN:ZDB-GENE-101007-5
See related
Ensembl:ENSDARG00000078133 AllianceGenome:ZFIN:ZDB-GENE-101007-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kdm2a; jhdm1A-a
Summary
Predicted to enable DNA binding activity; dioxygenase activity; and zinc ion binding activity. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (21754497..21781116)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (21457214..21483869)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene RAN, member RAS oncogene family Neighboring gene syntaxin 3b Neighboring gene ankyrin repeat domain 13 family, member D Neighboring gene C-terminal binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. Borgel J, et al. Nucleic Acids Res, 2017 Feb 17. PMID 28180290, Free PMC Article
  2. The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Yu SH, et al. Biochim Biophys Acta Gene Regul Mech, 2018 Feb. PMID 29378332, Free PMC Article
  3. Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Zhang J, et al. Front Endocrinol (Lausanne), 2018. PMID 30631305, Free PMC Article
  4. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Fellous A, et al. Gene, 2019 Mar 1. PMID 30458291
  5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysine-specific demethylase 2B; lysine-specific demethylase 2A
Names
lysine (K)-specific demethylase 2A
unm_sa1479
XP_001339797.3
XP_005173200.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    21754497..21781116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001339761.7 → XP_001339797.3  lysine-specific demethylase 2A isoform X1

    UniProtKB/TrEMBL
    A0A8M1PZC6
    Related
    ENSDARP00000145227.1, ENSDART00000186326.1
    Conserved Domains (7) summary
    cd09293
    Location:1075 → 1230
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:150 → 221
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02008
    Location:524 → 558
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1036 → 1060
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1002 → 1042
    F-box-like; F-box-like
    pfam16866
    Location:563 → 624
    PHD_4; PHD-finger
    cl21464
    Location:197 → 297
    cupin_like; Conserved domain found in cupin and related proteins

  2. XM_005173143.4 → XP_005173200.1  lysine-specific demethylase 2A isoform X2

    UniProtKB/TrEMBL
    A0A8M2BKX8, E7F0J6
    Related
    ENSDARP00000099910.3, ENSDART00000111839.4
    Conserved Domains (7) summary
    cd09293
    Location:1065 → 1220
    AMN1; Antagonist of mitotic exit network protein 1
    smart00558
    Location:150 → 221
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02008
    Location:524 → 558
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1026 → 1050
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:992 → 1032
    F-box-like; F-box-like
    pfam16866
    Location:563 → 624
    PHD_4; PHD-finger
    cl21464
    Location:197 → 297
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein
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