3AV4,3QMB,4NW3,4D4W


Conserved Protein Domain Family
zf-CXXC
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pfam02008: zf-CXXC (this model, PSSM-Id:251032 is obsolete and has been replaced by 366873)
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CXXC zinc finger domain
This domain contains eight conserved cysteine residues that bind to two zinc ions. The CXXC domain is found in a variety of chromatin-associated proteins. This domain binds to nonmethyl-CpG dinucleotides. The domain is characterized by two repeats, and shows a peculiar internal duplication in which the second unit is inserted into the first one. Each of these units is characterized by four conserved cysteines, displaying a CXXCXXCX(n)C motif that chelate a Zn+2 ion. The DNA binding interface has been identified by NMR. In eukaryotes, the CXXC domain is found in stramenopiles, plants and metazoans. Plants possess a mono-CXXC domain that is present in distinct chromatin proteins. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases.
Links
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Statistics
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PSSM-Id: 251032
Aligned: 35 rows
Threshold Bit Score: 41.1776
Created: 16-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3AV4_A  358 ENAMKRRRCGVCEVCQQPE-CGKCKACKD---MVKFGGTGRSKQ-ACLKRRC 404  house mouse
Q7SZX5  490 KPYKKWVPCGRCWACQTTVdCGKCVSCRNgrlRHRLNIHSRKVV-KCRKRKC 540  zebrafish
Q91WA4  250 SGKKKRKRCGMCAPCRRRInCEQCSSCRN---RKT------GHQ-ICKFRKC 291  house mouse
Q29IC4  136 KEPKAGKRCGTCEGCRRPN-CNQCNACRI---RVG------HKP-RCIYRTC 176  Drosophila pseudoobscura
Q7ZYD4  210 RVLHKSDECGVCQGCCREDdCEGCSVCLD---KMHKPGMDIKEK--CLQRRC 256  African clawed frog
Q28EE6  211 RNLRKGDDCGMCQGCQRDDdCEGCSVCLD---KMHKPDADIKER--CLLRRC 257  tropical clawed frog
Q28EE6  163 QKLHKNTGCGTCEACKVTEnCGHCTVCLL---R-SHNPEFSSSW-KCVRRRC 209  tropical clawed frog
Q2KIY8  168 QRMFKRVGCGECTACQVKEdCGACSTCLL---QLPHDVASGLFC-KCERRRC 215  cattle
Q9Z2E2  235 RIMEKSRGCGVCRGCQTQEdCGHCCICLR---SPR---PGLKRQwRCLQRRC 280  house mouse
4D4W_A    7 QRMFKRVGCGECAACQVTEdCGACSTCLL---QLPHDVASGLFC-KCERRRC 54   human
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