rabep2 rabaptin, RAB GTPase binding effector protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rabep2provided by ZNC
Official Full Name: rabaptin, RAB GTPase binding effector protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-572
See related: Ensembl:ENSDARG00000061213 AllianceGenome:ZFIN:ZDB-GENE-070112-572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158419
Summary: Predicted to enable GTPase activator activity and growth factor activity. Predicted to act upstream of or within cell projection organization; endocytosis; and protein transport. Predicted to be located in cell projection; early endosome; and microtubule organizing center. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human RABEP2 (rabaptin, RAB GTPase binding effector protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (26157722..26171558, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (26026851..26040687, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rab GTPase-binding effector protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080625.2 → NP_001074094.2 rab GTPase-binding effector protein 2

Status: VALIDATED

Source sequence(s)

CF265814, FP016243

UniProtKB/TrEMBL

A0A8M1NCV5, F1Q793

Related

ENSDARP00000103396.3, ENSDART00000113890.5

Conserved Domains (3) summary

pfam08172
Location:371 → 405

CASP_C; CASP C terminal

pfam09311
Location:221 → 460

Rab5-bind; Rabaptin-like protein

cl01825
Location:41 → 92

Phage_Mu_Gam; Bacteriophage Mu Gam like protein