ASB9 ankyrin repeat and SOCS box containing 9 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ASB9provided by VGNC
Official Full Name: ankyrin repeat and SOCS box containing 9provided by VGNC
Primary source: VGNC:VGNC:26202
See related: BGD:BT23126; Ensembl:ENSBTAG00000009198
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (128217622..128246219)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study results support a physiologically relevant role of ASB9 in the bovine ovulatory follicles by targeting specific proteins likely for degradation, contributing to reduced granulosa cells (GC) proliferation, and could be involved in the final GC differentiation into luteal cells.
Title: Gonadotropin regulation of ankyrin-repeat and SOCS-box protein 9 (ASB9) in ovarian follicles and identification of binding partners.
The ovulation process is associated with LH/hCG-induced up-regulation of ASB9 mRNA and protein in granulosa cells of bovine preovulatory follicles. The study provides evidence that ASB9 reduces granulosa cells proliferation at the time of ovulation and could be involved in the final differentiation of granulosa cells into luteal cells.
Title: Gonadotropin regulation of ankyrin-repeat and SOCS-box protein 9 (ASB9) in ovarian follicles and identification of binding partners.

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General gene information

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Markers

XBM38 (e-PCR), detects polymorphism
- UniSTS:250997

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 9

Names: ankyrin repeat and SOCS box-containing 9-like protein; ankyrin repeat/SOCS box-containing 9-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191166.1 → NP_001178095.1 ankyrin repeat and SOCS box protein 9

See identical proteins and their annotated locations for NP_001178095.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000030

UniProtKB/TrEMBL

E1BKE5, E4NKF6

Related

ENSBTAP00000012118.5, ENSBTAT00000012118.6

Conserved Domains (5) summary

cd00204
Location:57 → 181

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:67 → 157

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:31 → 83

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:29 → 60

ANK; ANK repeat [structural motif]

cl02533
Location:246 → 286

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

Range

128217622..128246219

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005228459.4 → XP_005228516.1 ankyrin repeat and SOCS box protein 9 isoform X1

See identical proteins and their annotated locations for XP_005228516.1

UniProtKB/TrEMBL

E4NKF7

Related

ENSBTAP00000054798.1, ENSBTAT00000066073.3

Conserved Domains (3) summary

cd00204
Location:57 → 181

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:29 → 60

ANK; ANK repeat [structural motif]

cl02533
Location:184 → 223

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...