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Conserved domains on  [gi|300793992|ref|NP_001178095|]
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ankyrin repeat and SOCS box protein 9 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-230 6.48e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.47  E-value: 6.48e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  35 HEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNL 114
Cdd:COG0666   59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 115 LLQYGASPH-PENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVN-QGRG 192
Cdd:COG0666  139 LLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDND 218

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 300793992 193 LDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:COG0666  219 GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 246-286 2.00e-16

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03728:

Pssm-ID: 470605  Cd Length: 42  Bit Score: 71.36  E-value: 2.00e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 300793992 246 EGPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLY 41
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-230 6.48e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.47  E-value: 6.48e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  35 HEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNL 114
Cdd:COG0666   59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 115 LLQYGASPH-PENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVN-QGRG 192
Cdd:COG0666  139 LLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDND 218

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 300793992 193 LDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:COG0666  219 GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
Ank_2 pfam12796
Ankyrin repeats (3 copies);
67-157 2.82e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 2.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992   67 LHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGASPHPENDLaSPIHEAAKRGHMQCIES 146
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGR-TALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 300793992  147 LVAHGGDIDQN 157
Cdd:pfam12796  80 LLEKGADINVK 90
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 246-286 2.00e-16

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 71.36  E-value: 2.00e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 300793992 246 EGPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLY 41
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 65-187 7.02e-16

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 77.60  E-value: 7.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  65 SPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGA--SPHPENDLaspIHEAAKRGHMQ 142
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisDPHAAGDL---LCTAAKRNDLT 636

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 300793992 143 CIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNV 187
Cdd:PLN03192 637 AMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 247-285 1.16e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.63  E-value: 1.16e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 300793992  247 GPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLL 285
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 249-286 1.80e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 46.63  E-value: 1.80e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 300793992   249 SSLMQLCRLRIRKCFGikqhhKITELNLPEELKRFLLH 286
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 65-90 3.22e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 3.22e-05
                           10        20
                   ....*....|....*....|....*.
gi 300793992    65 SPLHEACLGGHPSCVKILLRHGANVN 90
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 88-222 4.21e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.52  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992   88 NVNSVTVDWHTPLFNACVSGSH-ECVNLLLQYGASPHPENDLaspIHEAAKRGHmQCIESLVAHGGDIDQNIHHLG---- 162
Cdd:TIGR00870  44 NINCPDRLGRSALFVAAIENENlELTELLLNLSCRGAVGDTL---LHAISLEYV-DAVEAILLHLLAAFRKSGPLEland 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  163 ----------TPLYMACENLQVACAKKLLESGVNVN-----------QGRGL----DSPLHAVARASSGELVSLLLDFGA 217
Cdd:TIGR00870 120 qytseftpgiTALHLAAHRQNYEIVKLLLERGASVParacgdffvksQGVDSfyhgESPLNAAACLGSPSIVALLSEDPA 199


                  ....*
gi 300793992  218 DTQAR 222
Cdd:TIGR00870 200 DILTA 204
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-230 6.48e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.47  E-value: 6.48e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  35 HEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNL 114
Cdd:COG0666   59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 115 LLQYGASPH-PENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVN-QGRG 192
Cdd:COG0666  139 LLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDND 218

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 300793992 193 LDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:COG0666  219 GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-230 2.58e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.53  E-value: 2.58e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  30 DWSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSH 109
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 110 ECVNLLLQYGASP-HPENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVN 188
Cdd:COG0666  167 EIVKLLLEAGADVnARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 300793992 189 -QGRGLDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:COG0666  247 aKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-230 1.54e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 1.54e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  35 HEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNL 114
Cdd:COG0666   26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 115 LLQYGASPH-PENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVN-QGRG 192
Cdd:COG0666  106 LLEAGADVNaRDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNaRDND 185

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 300793992 193 LDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:COG0666  186 GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-191 1.27e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 1.27e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  29 SDWSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGS 108
Cdd:COG0666  119 DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 109 HECVNLLLQYGASPHPENDL-ASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNV 187
Cdd:COG0666  199 LEIVKLLLEAGADVNAKDNDgKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278


                 ....
gi 300793992 188 NQGR 191
Cdd:COG0666  279 AAAL 282
Ank_2 pfam12796
Ankyrin repeats (3 copies);
67-157 2.82e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 2.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992   67 LHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGASPHPENDLaSPIHEAAKRGHMQCIES 146
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGR-TALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 300793992  147 LVAHGGDIDQN 157
Cdd:pfam12796  80 LLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
35-126 5.14e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 5.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992   35 HEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHgANVNSVTVDWhTPLFNACVSGSHECVNL 114
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 300793992  115 LLQYGASPHPEN 126
Cdd:pfam12796  80 LLEKGADINVKD 91
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 246-286 2.00e-16

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 71.36  E-value: 2.00e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 300793992 246 EGPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLY 41
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 65-187 7.02e-16

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 77.60  E-value: 7.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  65 SPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGA--SPHPENDLaspIHEAAKRGHMQ 142
Cdd:PLN03192 560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisDPHAAGDL---LCTAAKRNDLT 636

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 300793992 143 CIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNV 187
Cdd:PLN03192 637 AMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 42-249 7.24e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 77.01  E-value: 7.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  42 RLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPL---FNACVSGSH--ECVNLLL 116
Cdd:PHA03100  14 KVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLhylSNIKYNLTDvkEIVKLLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 117 QYGASPH-PENDLASPIHEAA--KRGHMQCIESLVAHGGDID------QNIHHLgtplYMACENLQVACAKKLLESGVNV 187
Cdd:PHA03100  94 EYGANVNaPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNiknsdgENLLHL----YLESNKIDLKILKLLIDKGVDI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 188 NQG------------------RGlDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPLE--VVPPESPLIQLLQREG 247
Cdd:PHA03100 170 NAKnrvnyllsygvpinikdvYG-FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHiaILNNNKEIFKLLLNNG 248


                 ..
gi 300793992 248 PS 249
Cdd:PHA03100 249 PS 250
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 32-247 1.87e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 76.26  E-value: 1.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  32 SPVHEAAIHGRLLSL-RSLINQGWPVNLITADRVSPLHEACLGGHPS-CVKILLRHGANVNSVTVDWHTPLFNA-CVSGS 108
Cdd:PHA02876 275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYDTeNIRTLIMLGADVNAADRLYITPLHQAsTLDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 109 HECVNLLLQYGASPHPENDL-ASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMA-CENLQVACAKKLLESGVN 186
Cdd:PHA02876 355 KDIVITLLELGANVNARDYCdKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGAN 434

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300793992 187 VN-QGRGLDSPLH-AVARASSGELVSLLLDFGADTQARNAEGKRPLEVVPPESPLIQLLQREG 247
Cdd:PHA02876 435 VNsKNKDLSTPLHyACKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILLHYG 497
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 79-233 3.36e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 75.30  E-value: 3.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  79 VKILLRHGANVNSVTVDW-HTPLFNACVSGSHECVNLLLQYGASPH-PENDLASPIHEAAKRGHMQCIESLVAHGGDIDQ 156
Cdd:PHA02878 150 TKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 157 NIHHLGTPLYMA---CENLQVAcaKKLLESGVNVNQG---RGLdSPLHAVARasSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:PHA02878 230 RDKCGNTPLHISvgyCKDYDIL--KLLLEHGVDVNAKsyiLGL-TALHSSIK--SERKLKLLLEYGADINSLNSYKLTPL 304


                 ...
gi 300793992 231 EVV 233
Cdd:PHA02878 305 SSA 307
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 31-219 1.62e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 70.02  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  31 WSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTV-DWHTPLFNACVSGSH 109
Cdd:PHA02875  36 ISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 110 ECVNLLLQYGASPH-PENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVN 188
Cdd:PHA02875 116 DIMKLLIARGADPDiPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195

                        170       180       190
                 ....*....|....*....|....*....|...
gi 300793992 189 Q-GRGLDSPLHAVA-RASSGELVSLLLDFGADT 219
Cdd:PHA02875 196 YfGKNGCVAALCYAiENNKIDIVRLFIKRGADC 228
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 41-230 2.28e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.61  E-value: 2.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  41 GRLLSLRSLI-NQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYG 119
Cdd:PHA02874  12 GDIEAIEKIIkNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 120 AS------PHPENDLASPI------------------HEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVA 175
Cdd:PHA02874  92 VDtsilpiPCIEKDMIKTIldcgidvnikdaelktflHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFD 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 300793992 176 CAKKLLESG--VNVNQGRGlDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:PHA02874 172 IIKLLLEKGayANVKDNNG-ESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPL 227
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-232 2.50e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.61  E-value: 2.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  45 SLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGASPH- 123
Cdd:PHA02874 106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANv 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 124 PENDLASPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESGVNVNQGRGlDSPLH-AVAR 202
Cdd:PHA02874 186 KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASINDQDIDG-STPLHhAINP 264

                        170       180       190
                 ....*....|....*....|....*....|
gi 300793992 203 ASSGELVSLLLDFGADTQARNAEGKRPLEV 232
Cdd:PHA02874 265 PCDIDIIDILLYHKADISIKDNKGENPIDT 294
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 246-286 4.00e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 62.51  E-value: 4.00e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 300793992 246 EGPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLY 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
132-223 1.59e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  132 IHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLLESgVNVNQGRGLDSPLHAVARASSGELVSL 211
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 300793992  212 LLDFGADTQARN 223
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 46-230 4.03e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.82  E-value: 4.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  46 LRSLINQGWPVNL-ITADRvSPLHeACLGG---HPSCVKILLRHGANVNSVTVDWHTPLfnACVSGSHEC----VNLLLQ 117
Cdd:PHA03095 100 IKLLIKAGADVNAkDKVGR-TPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLID 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 118 YGASPHP-ENDLASPIHEAAK--RGHMQCIESLVAHGGDIDQNIHHLGTPL-YMA----CENLQVAcakKLLESGVNVN- 188
Cdd:PHA03095 176 AGADVYAvDDRFRSLLHHHLQsfKPRARIVRELIRAGCDPAATDMLGNTPLhSMAtgssCKRSLVL---PLLIAGISINa 252

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 300793992 189 QGRGLDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:PHA03095 253 RNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 248-286 4.05e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 59.41  E-value: 4.05e-12
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 300793992 248 PSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLY 40
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 33-232 9.60e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.82  E-value: 9.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  33 PVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRhganvnSVTVDwhtPLFNACVSGSHECV 112
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIR------SINKC---SVFYTLVAIKDAFN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 113 N--------LLLQYgasphPENDLASPIHEAAKRGHMQCIES-----LVAHGGDIDQNIHHLG-TPLYMACENLQVACAK 178
Cdd:PHA02878 111 NrnveifkiILTNR-----YKNIQTIDLVYIDKKSKDDIIEAeitklLLSYGADINMKDRHKGnTALHYATENKDQRLTE 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 300793992 179 KLLESGVNVNQ-GRGLDSPLHAVARASSGELVSLLLDFGADTQARNAEGKRPLEV 232
Cdd:PHA02878 186 LLLSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHI 240
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 247-285 1.16e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.63  E-value: 1.16e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 300793992  247 GPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLL 285
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 62-230 3.16e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.00  E-value: 3.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  62 DRVSpLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGASPHPEN-DLASPIHEAAKRGH 140
Cdd:PHA02875   2 DQVA-LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpDIESELHDAVEEGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 141 MQCIESLVAHGGDIDQNIHHLG-TPLYMACENLQVACAKKLLESGVNVN-QGRGLDSPLHAVARASSGELVSLLLDFGAD 218
Cdd:PHA02875  81 VKAVEELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDiPNTDKFSPLHLAVMMGDIKGIELLIDHKAC 160

                        170
                 ....*....|..
gi 300793992 219 TQARNAEGKRPL 230
Cdd:PHA02875 161 LDIEDCCGCTPL 172
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 32-221 6.85e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 59.69  E-value: 6.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  32 SPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVK-----------------------------IL 82
Cdd:PHA02876 180 TPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKaiidnrsninkndlsllkairnedletslLL 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  83 LRHGANVNSVTVDWHTPLFNACVSGS-HECVNLLLQYGASPHPEN-DLASPIHEAAKRGH-MQCIESLVAHGGDIDQNIH 159
Cdd:PHA02876 260 YDAGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNiKGETPLYLMAKNGYdTENIRTLIMLGADVNAADR 339

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300793992 160 HLGTPLYMACE-NLQVACAKKLLESGVNVNQGRGLD-SPLHAVARASSGELVSLLLDFGADTQA 221
Cdd:PHA02876 340 LYITPLHQASTlDRNKDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEA 403
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 80-230 1.16e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.92  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  80 KILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLLQYGASPHPEN-DLASPIHEAAKRGHMQCIESLVAHGGDIDQNi 158
Cdd:PHA02876 162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIAlDDLSVLECAVDSKNIDTIKAIIDNRSNINKN- 240

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300793992 159 hhlGTPLYMACENLQVACAKKLLESGVNVNQ-GRGLDSPLHAVARASS-GELVSLLLDFGADTQARNAEGKRPL 230
Cdd:PHA02876 241 ---DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPL 311
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 49-155 1.23e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.52  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  49 LINQGWPVNLITADRVSPLHEACLGGHP--SCVKILLRHGANVNSVT-VDW---------------HTPLFNACVSGSHE 110
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKNrVNYllsygvpinikdvygFTPLHYAVYNNNPE 206

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 300793992 111 CVNLLLQYGASPHPENDLA-SPIHEAAKRGHMQCIESLVAHGGDID 155
Cdd:PHA03100 207 FVKYLLDLGANPNLVNKYGdTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 32-198 8.95e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 8.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  32 SPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGAN----------------------- 88
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildcgid 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  89 VNSVTVDWHTPLFNACVSGSHECVNLLLQYGASPHPENDLAS-PIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYM 167
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCyPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                        170       180       190
                 ....*....|....*....|....*....|...
gi 300793992 168 ACENLQVACAKKLLESGVNVNQ--GRGLdSPLH 198
Cdd:PHA02874 197 AAEYGDYACIKLLIDHGNHIMNkcKNGF-TPLH 228
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 44-120 1.20e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.84  E-value: 1.20e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300793992  44 LSLRSLINQGWPVNLITADRVSPLHEACLGG-HPSCVKILLRHGANVNSVTVDWHTPLFNACvsGSHECVNLLLQYGA 120
Cdd:PHA02876 423 MSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGA 498
Ank_4 pfam13637
Ankyrin repeats (many copies);
31-83 2.17e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 2.17e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 300793992   31 WSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILL 83
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 249-286 1.80e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 46.63  E-value: 1.80e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 300793992   249 SSLMQLCRLRIRKCFGikqhhKITELNLPEELKRFLLH 286
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 248-284 1.81e-07

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 46.79  E-value: 1.81e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 300793992 248 PSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFL 284
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFL 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-91 2.19e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 2.19e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300793992   31 WSPVHEAAIHGRLLSLRSLINQgWPVNLITADRvSPLHEACLGGHPSCVKILLRHGANVNS 91
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADINV 89
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 30-120 5.18e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.83  E-value: 5.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  30 DWSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHP-SCVKILLRHGANVNSVTVDWHTPLFNACVSGS 108
Cdd:PHA02876 375 DKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSKNKDLSTPLHYACKKNC 454

                         90
                 ....*....|...
gi 300793992 109 H-ECVNLLLQYGA 120
Cdd:PHA02876 455 KlDVIEMLLDNGA 467
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 15-122 9.96e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.60  E-value: 9.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  15 DMRLFSNPLMGD--FVSDWSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSV 92
Cdd:PHA02875  85 EELLDLGKFADDvfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164

                         90       100       110
                 ....*....|....*....|....*....|
gi 300793992  93 TVDWHTPLFNACVSGSHECVNLLLQYGASP 122
Cdd:PHA02875 165 DCCGCTPLIIAMAKGDIAICKMLLDSGANI 194
Ank_4 pfam13637
Ankyrin repeats (many copies);
130-181 1.28e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 1.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 300793992  130 SPIHEAAKRGHMQCIESLVAHGGDIDQNIHHLGTPLYMACENLQVACAKKLL 181
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
63-116 1.41e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 1.41e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 300793992   63 RVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLLL 116
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 36-131 1.63e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  36 EAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSGSHECVNLL 115
Cdd:PTZ00322  88 QLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167

                         90
                 ....*....|....*.
gi 300793992 116 LQYGASPHPENDLASP 131
Cdd:PTZ00322 168 SRHSQCHFELGANAKP 183
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 43-230 1.74e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.91  E-value: 1.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  43 LLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHT------------------------ 98
Cdd:PHA02876 158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSvlecavdsknidtikaiidnrsni 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  99 -----PLFNACVSGSHECVNLLLQYGASPHPENDLA-SPIHEAAKRGHM-QCIESLVAHGGDIDQNIHHLGTPLYMACEN 171
Cdd:PHA02876 238 nkndlSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKnTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKN 317

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300793992 172 -LQVACAKKLLESGVNVNQGRGL-DSPLH-AVARASSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:PHA02876 318 gYDTENIRTLIMLGADVNAADRLyITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPI 379
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 248-286 5.16e-06

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 42.46  E-value: 5.16e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 300793992 248 PSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 246-286 5.20e-06

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 42.55  E-value: 5.20e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 300793992 246 EGPSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNH 41
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 248-285 6.65e-06

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 42.43  E-value: 6.65e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 300793992 248 PSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLL 285
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 248-286 8.96e-06

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 42.02  E-value: 8.96e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 300793992 248 PSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03720    3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-230 1.48e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.17  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  35 HEAAIHGRLLS--------LRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKI---LLRHGANVNSVTVDWHTPLF-- 101
Cdd:PHA03095  11 MEAALYDYLLNasnvtveeVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHly 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 102 --NACVSgshECVNLLLQYGASPHPENDLA-SPIHE--AAKRGHMQCIESLVAHGGDIDQNIHHLGTPL--YMACENLQV 174
Cdd:PHA03095  91 lyNATTL---DVIKLLIKAGADVNAKDKVGrTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANV 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 175 ACAKKLLESGVNV--NQGRGlDSPLH--AVARASSGELVSLLLDFGADTQARNAEGKRPL 230
Cdd:PHA03095 168 ELLRLLIDAGADVyaVDDRF-RSLLHhhLQSFKPRARIVRELIRAGCDPAATDMLGNTPL 226
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 24-168 1.92e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  24 MGDFVSDWSPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNA 103
Cdd:PHA02878 162 MKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300793992 104 CVS-GSHECVNLLLQYGASPHPENDLA--SPIHEAAKrgHMQCIESLVAHGGDIDQNIHHLGTPLYMA 168
Cdd:PHA02878 242 VGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSA 307
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 248-286 2.06e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 40.75  E-value: 2.06e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 300793992 248 PSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLY 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
96-148 2.34e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 2.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 300793992   96 WHTPLFNACVSGSHECVNLLLQYGASP-HPENDLASPIHEAAKRGHMQCIESLV 148
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADInAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 246-285 2.88e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 40.27  E-value: 2.88e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 300793992 246 EGPSSLMQLCRLRIRKCFGIkqhHKITELNLPEELKRFLL 285
Cdd:cd03717    1 TSVRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLK 37
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 65-90 3.22e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 3.22e-05
                           10        20
                   ....*....|....*....|....*.
gi 300793992    65 SPLHEACLGGHPSCVKILLRHGANVN 90
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 32-90 7.44e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.89  E-value: 7.44e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 300793992  32 SPVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVN 90
Cdd:PHA03100 194 TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 65-93 1.53e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 1.53e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 300793992   65 SPLHEACL-GGHPSCVKILLRHGANVNSVT 93
Cdd:pfam00023   4 TPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 33-154 2.01e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  33 PVHEAAIHGRLLSLRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNACVSgSHECV 112
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAI 238

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 300793992 113 NLLLQYGASPHPENDLASPIHEAAKRG-HMQCIESLVAHGGDI 154
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADI 281
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 45-100 2.58e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 41.89  E-value: 2.58e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 300793992  45 SLRSLINQGWPVNLITAD-RVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPL 100
Cdd:PHA02884  85 AAKLLIRYGADVNRYAEEaKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPI 141
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 248-284 7.89e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 36.47  E-value: 7.89e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 300793992 248 PSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFL 284
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYL 39
Ank_5 pfam13857
Ankyrin repeats (many copies);
51-100 8.48e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 8.48e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 300793992   51 NQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPL 100
Cdd:pfam13857   4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 125-232 8.60e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 8.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 125 ENDLASPIHEAAKRGhmqcieslvahggDIDQNIHHLgtplyMACENLQVAC------AKKLLESGVNVNQgRGLD--SP 196
Cdd:PTZ00322  58 ENKDATPDHNLTTEE-------------VIDPVVAHM-----LTVELCQLAAsgdavgARILLTGGADPNC-RDYDgrTP 118

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 300793992 197 LHAVARASSGELVSLLLDFGADTQARNAEGKRPLEV 232
Cdd:PTZ00322 119 LHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLEL 154
PHA03095 PHA03095
ankyrin-like protein; Provisional
 112-232 9.01e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992 112 VNLLLQYGASPHPENDLAS-PIHEAAKRGHMQC---IESLVAHGGDIDQNIHHLGTPLYM-ACENLQVACAKKLLESGVN 186
Cdd:PHA03095  30 VRRLLAAGADVNFRGEYGKtPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGAD 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 300793992 187 VNQGRGLD-SPLHAVAR--ASSGELVSLLLDFGADTQARNAEGKRPLEV 232
Cdd:PHA03095 110 VNAKDKVGrTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPLAV 158
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 248-286 9.45e-04

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 36.36  E-value: 9.45e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 300793992 248 PSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03726    3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKH 41
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 63-137 1.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 39.97  E-value: 1.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300793992  63 RVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWH-TPLFNACVSGSHECVNLLLQYGASPHPE-NDLASPIHEAAK 137
Cdd:PHA02884  70 KTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQtNDMVTPIELALM 146
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 65-90 1.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 1.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 300793992   65 SPLHEACLGGHPSCVKILLRHGANVN 90
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADIN 29
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 246-286 1.98e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 35.98  E-value: 1.98e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 300793992 246 EGPSSLMQLCRLRIRKCFG---IKQHHKITELNLPEELKRFLLH 286
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGrlrLRCPVFMSFLPLPNRLKAYILY 44
PHA02946 PHA02946
ankyin-like protein; Provisional
 46-120 2.98e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 38.88  E-value: 2.98e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300793992  46 LRSLINQGWPVNLITADRVSPLHEACLGGHPSCVKILLRHGANVNSVTVDWHTPLFNacVSGSH----ECVNLLLQYGA 120
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYY--LSGTDdeviERINLLVQYGA 131
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 88-222 4.21e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.52  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992   88 NVNSVTVDWHTPLFNACVSGSH-ECVNLLLQYGASPHPENDLaspIHEAAKRGHmQCIESLVAHGGDIDQNIHHLG---- 162
Cdd:TIGR00870  44 NINCPDRLGRSALFVAAIENENlELTELLLNLSCRGAVGDTL---LHAISLEYV-DAVEAILLHLLAAFRKSGPLEland 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  163 ----------TPLYMACENLQVACAKKLLESGVNVN-----------QGRGL----DSPLHAVARASSGELVSLLLDFGA 217
Cdd:TIGR00870 120 qytseftpgiTALHLAAHRQNYEIVKLLLERGASVParacgdffvksQGVDSfyhgESPLNAAACLGSPSIVALLSEDPA 199


                  ....*
gi 300793992  218 DTQAR 222
Cdd:TIGR00870 200 DILTA 204
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 95-123 4.38e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 4.38e-03
                           10        20
                   ....*....|....*....|....*....
gi 300793992    95 DWHTPLFNACVSGSHECVNLLLQYGASPH 123
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 242-285 4.99e-03

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 34.19  E-value: 4.99e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 300793992   242 LLQREGPSSLMQLCRLRIRKCFGIKQhhkITELNLPEELKRFLL 285
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQ---IKTLPLPPKLKDYLS 41
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 79-171 5.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 37.66  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300793992  79 VKILLRHGANVNS----VTVDWHTPLFNACVSGSHECVNLLLQYGA--SPHPENDLASPIHEAAKRGHMQCIESLVAHGG 152
Cdd:PHA02884  49 IDAILKLGADPEApfplSENSKTNPLIYAIDCDNDDAAKLLIRYGAdvNRYAEEAKITPLYISVLHGCLKCLEILLSYGA 128

                         90       100
                 ....*....|....*....|..
gi 300793992 153 DIDQNIHHLGTPLYMA---CEN 171
Cdd:PHA02884 129 DINIQTNDMVTPIELAlmiCNN 150
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 246-286 5.71e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 34.42  E-value: 5.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 300793992 246 EGPSSLMQLCRLRIRKCFGIKQHHK---ITELNLPEELKRFLLH 286
Cdd:cd03731    1 ENPRPLKHLCRLKIRKLMGLQKLQQpssMKKLPLPPALKRYILY 44
Ank_4 pfam13637
Ankyrin repeats (many copies);
163-213 6.61e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.17  E-value: 6.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 300793992  163 TPLYMACENLQVACAKKLLESGVNVN-QGRGLDSPLHAVARASSGELVSLLL 213
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINaVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 163-188 7.31e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 7.31e-03
                           10        20
                   ....*....|....*....|....*.
gi 300793992   163 TPLYMACENLQVACAKKLLESGVNVN 188
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 248-286 8.02e-03

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 33.80  E-value: 8.02e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 300793992 248 PSSLMQLCRLRIRKCFGIKQHHKITELNLPEELKRFLLH 286
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLY 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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