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Trit1 tRNA isopentenyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 66966, updated on 5-Mar-2024

Summary

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Official Symbol
Trit1provided by MGI
Official Full Name
tRNA isopentenyltransferase 1provided by MGI
Primary source
MGI:MGI:1914216
See related
Ensembl:ENSMUSG00000028653 AllianceGenome:MGI:1914216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IPT; IPPT; MOD5; 2310075G14Rik
Summary
Predicted to enable tRNA dimethylallyltransferase activity. Predicted to be involved in tRNA modification. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.3), CNS E14 (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122910342..122948742)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123016544..123054949)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene STARR-positive B cell enhancer ABC_E7983 Neighboring gene predicted gene, 54255 Neighboring gene STARR-positive B cell enhancer ABC_E11253 Neighboring gene v-myc avian myelocytomatosis viral oncogene lung carcinoma derived Neighboring gene STARR-positive B cell enhancer ABC_E2710 Neighboring gene STARR-positive B cell enhancer ABC_E3511 Neighboring gene STARR-positive B cell enhancer ABC_E4662 Neighboring gene STARR-positive B cell enhancer ABC_E4663 Neighboring gene predicted gene 12923 Neighboring gene predicted gene, 46868 Neighboring gene bone morphogenetic protein 8b Neighboring gene predicted gene, 17244 Neighboring gene 3-oxoacid CoA transferase 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian Trit1 is a tRNA([Ser]Sec)-isopentenyl transferase required for full selenoprotein expression. Fradejas N, et al. Biochem J, 2013 Mar 1. PMID 23289710
  2. The Effect of tRNA([Ser]Sec) Isopentenylation on Selenoprotein Expression. Fradejas-Villar N, et al. Int J Mol Sci, 2021 Oct 23. PMID 34768885, Free PMC Article
  3. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Effect of tRNA([Ser]Sec) Isopentenylation on Selenoprotein Expression.
    Title: The Effect of tRNA([Ser]Sec) Isopentenylation on Selenoprotein Expression.
  2. Knockdown of Trit1 reduces expression of selenoproteins.
    Title: Mammalian Trit1 is a tRNA([Ser]Sec)-isopentenyl transferase required for full selenoprotein expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dimethylallyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dimethylallyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA dimethylallyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA dimethylallyltransferase
Names
IPP transferase
IPTase
isopentenyl-diphosphate:tRNA isopentenyltransferase
tRNA dimethylallyltransferase, mitochondrial
tRNA isopentenyltransferase, mitochondrial
NP_080149.2
XP_017175848.1
XP_036020248.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025873.3 → NP_080149.2  tRNA dimethylallyltransferase precursor

    See identical proteins and their annotated locations for NP_080149.2

    Status: VALIDATED

    Source sequence(s)
    AK003556, AL606906
    Consensus CDS
    CCDS18607.1
    UniProtKB/Swiss-Prot
    B1ARS6, Q80UN9, Q9D1H5
    Related
    ENSMUSP00000099709.4, ENSMUST00000102649.4
    Conserved Domains (3) summary
    PLN02748
    Location:17 → 419
    PLN02748; tRNA dimethylallyltransferase
    COG0324
    Location:24 → 333
    MiaA; tRNA A37 N6-isopentenylltransferase MiaA [Translation, ribosomal structure and biogenesis]
    pfam12171
    Location:395 → 419
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RNA

  1. NR_151450.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK003556, AK010176, AL606906
    Related
    ENSMUST00000147165.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    122910342..122948742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164355.1 → XP_036020248.1  tRNA dimethylallyltransferase isoform X1

    Conserved Domains (2) summary
    pfam12171
    Location:310 → 334
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl40481
    Location:24 → 248
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  2. XM_017320359.3 → XP_017175848.1  tRNA dimethylallyltransferase isoform X2

    Conserved Domains (2) summary
    pfam12171
    Location:168 → 192
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam01715
    Location:7 → 105
    IPPT; IPP transferase

RNA

  1. XR_003954996.2 RNA Sequence

  2. XR_376340.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UN9.2 GenPept UniProtKB/Swiss-Prot:Q80UN9

Gene LinkOut

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