adarb1a adenosine deaminase RNA specific B1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adarb1aprovided by ZNC
Official Full Name: adenosine deaminase RNA specific B1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000627-2
See related: Ensembl:ENSDARG00000041609 AllianceGenome:ZFIN:ZDB-GENE-000627-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: red1; adar2; adarb1
Summary: Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; lateral line development; and neural crest cell development. Predicted to be active in cytoplasm and nucleolus. Is expressed in several structures, including ceratobranchial cartilage; fin bud; nervous system; neural plate; and pericardial region. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (12641575..12693865, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (12616800..12669068, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adar2 Edits the Q/R site of AMPA receptor Subunit gria2alpha transcript to ensure normal development of nervous system and cranial neural crest cells
Title: Zebrafish Adar2 Edits the Q/R site of AMPA receptor Subunit gria2α transcript to ensure normal development of nervous system and cranial neural crest cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2'-deoxyadenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA-specific adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info
involved_in adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adenosine deaminase, RNA-specific, B1; double-stranded RNA-specific editase 1a

Names: double-stranded RNA-specific editase

NP_571685.2

EC 3.5.4.4

XP_021325050.1

EC 3.5.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131610.3 → NP_571685.2 double-stranded RNA-specific editase 1a

Status: VALIDATED

Source sequence(s)

CR847870

UniProtKB/TrEMBL

A0A8M1P669, A5WUX1

Related

ENSDARP00000044573.7, ENSDART00000044574.9

Conserved Domains (3) summary

smart00358
Location:95 → 157

DSRM; Double-stranded RNA binding motif

smart00552
Location:341 → 717

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd00048
Location:254 → 303

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

12641575..12693865 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469375.1 → XP_021325050.1 adenosine deaminase, RNA-specific, B1 isoform X1

UniProtKB/TrEMBL

A0A8M1P669, A5WUX1

Conserved Domains (3) summary

smart00358
Location:95 → 157

DSRM; Double-stranded RNA binding motif

smart00552
Location:341 → 717

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd00048
Location:254 → 303

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...