1DI2,1QU6,1EKZ


Conserved Protein Domain Family
DSRM
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cd00048: DSRM (this model, PSSM-Id:238007 is obsolete and has been replaced by 380679)
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Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, RNases H1, and dsRNA dependent adenosine deaminases.
Links
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Statistics
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PSSM-Id: 238007
Aligned: 154 rows
Threshold Bit Score: 38.4075
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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dsRNA binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:dsRNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      #     ##                                                       ####  #          
1DI2_A       1 MPVGSLQELAvqk----gwrLPEYTVaQESGpph-krEFTITCRVet---------fVETGSGTSKQVAKRVAAEKLLTK 66   African clawed frog
466149     275 DPKKALQKFFere-----gfDMNFEF-SEQGqgh-thKWVCSIELpveidgvdraftASATVSTSKKDAQIQCALDACRI 347  Caenorhabditis e...
127156       2 DIKSFLYQFCaks-----qiEPKFDI-RQTGpkn-rqRFLCEVRVepn-------tyIGVGNSTNKKDAEKNACRDFVNY 67   fruit fly
2500541      3 DVKNFLYAWCgkr-----kmTPSYEI-RAVGnkn-rqKFMCEVRVegy-------nyTGMGNSTNKKDAQSNAARDFVNY 68   Bos taurus
BAA92111   111 AIYRPLDPKPfpnyranynfRGMYNQrYHCPvp---kIFYVQLTVgn---------nEFFGEGKTRQAARHNAAMKALQA 178  human
2500541    177 NAKARLNQYFqke-----kiQGEYKY-TQVGpdh-nrSFIAEMTIyikqi---grriFAREHGSNKKLAAQSCALSLVRQ 246  Bos taurus
3913436      4 DVKEFLYAWLgkn----kygNPTYDTkSETRsg--rqRFKCELRItgf-------gyTAFGNSTNKKDAATNAAQDFCQY 70   Caenorhabditis e...
2500557    369 NAKRQLYSLIgya-----slRLHYVTvKKPTav--dpNSIVECRVgdg-------tvLGTGVGRNIKIAGIRAAENALRD 434  baker's yeast
O95793      94 DPYSRMQSTYnyn-----mrGGAYPPrYFYPfpvpplLYQVELSVgg---------qQFNGKGKTRQAAKHDAAAKALRI 159  human
3650397    166 NAKAKLHQFMqmn-----kiQADYRY-TPVGpdh-arSFMAEMKIfvkql---nrtiTGRESGSNKQTASKSCALSLVRQ 235  Sciara ocellaris

Feature 1       
1DI2_A      67 F 67   African clawed frog
466149     348 L 348  Caenorhabditis elegans
127156      68 L 68   fruit fly
2500541     69 L 69   Bos taurus
BAA92111   179 L 179  human
2500541    247 L 247  Bos taurus
3913436     71 L 71   Caenorhabditis elegans
2500557    435 K 435  baker's yeast
O95793     160 L 160  human
3650397    236 L 236  Sciara ocellaris

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