U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cpxm2 carboxypeptidase X, M14 family member 2 [ Mus musculus (house mouse) ]

Gene ID: 55987, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Cpxm2provided by MGI
Official Full Name
carboxypeptidase X, M14 family member 2provided by MGI
Primary source
MGI:MGI:1926006
See related
Ensembl:ENSMUSG00000030862 AllianceGenome:MGI:1926006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpx2; CPX-2; 4632435C11Rik
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be located in extracellular region. Is expressed in blood vessel; nasal cavity epithelium; and skin. Orthologous to human CPXM2 (carboxypeptidase X, M14 family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 11.7), genital fat pad adult (RPKM 8.2) and 16 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 F3; 7 75.6 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (131634416..131756483, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (132032687..132154765, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34725 Neighboring gene G protein-coupled receptor 26 Neighboring gene STARR-seq mESC enhancer starr_20288 Neighboring gene STARR-seq mESC enhancer starr_20291 Neighboring gene carbohydrate sulfotransferase 15 Neighboring gene STARR-positive B cell enhancer ABC_E8215 Neighboring gene predicted gene 10584 Neighboring gene predicted gene, 34908

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Grabowski K, et al. Hypertens Res, 2022 Feb. PMID 34916661, Free PMC Article
  2. Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization. Xin X, et al. DNA Cell Biol, 1998 Oct. PMID 9809751
  3. Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. Buniello A, et al. PLoS One, 2013. PMID 23457544, Free PMC Article
  4. Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. Somma G, et al. J Assoc Res Otolaryngol, 2012 Jun. PMID 22383091, Free PMC Article
  5. Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor. Drake KA, et al. Development, 2020 Jul 31. PMID 32541007, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
    Title: Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
NOT located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
inactive carboxypeptidase-like protein X2
Names
carboxypeptidase X 2 (M14 family)
carboxypeptidase X2
metallocarboxypeptidase 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018867.5 → NP_061355.3  inactive carboxypeptidase-like protein X2 precursor

    See identical proteins and their annotated locations for NP_061355.3

    Status: VALIDATED

    Source sequence(s)
    AC100735, AK019509, BB027417
    Consensus CDS
    CCDS21921.1
    UniProtKB/Swiss-Prot
    O54860, Q8VDQ4, Q9D2L5
    UniProtKB/TrEMBL
    A0A0R4J0C4
    Related
    ENSMUSP00000033149.5, ENSMUST00000033149.5
    Conserved Domains (4) summary
    cd03869
    Location:322 → 647
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:651 → 726
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:146 → 301
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:145 → 300
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    131634416..131756483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508034.5 → XP_006508097.1  inactive carboxypeptidase-like protein X2 isoform X2

    UniProtKB/Swiss-Prot
    O54860, Q8VDQ4, Q9D2L5
    Conserved Domains (3) summary
    cd00057
    Location:145 → 300
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd03869
    Location:326 → 647
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cl21470
    Location:651 → 681
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  2. XM_006508033.5 → XP_006508096.1  inactive carboxypeptidase-like protein X2 isoform X1

    UniProtKB/Swiss-Prot
    O54860, Q8VDQ4, Q9D2L5
    Conserved Domains (3) summary
    cd11308
    Location:591 → 666
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:145 → 300
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:326 → 587
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  3. XM_011241864.1 → XP_011240166.1  inactive carboxypeptidase-like protein X2 isoform X3

    Conserved Domains (3) summary
    cd11308
    Location:445 → 520
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:13 → 94
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd03869
    Location:120 → 441
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

  4. XM_030242804.1 → XP_030098664.1  inactive carboxypeptidase-like protein X2 isoform X5

    Conserved Domains (3) summary
    cd11308
    Location:356 → 431
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:1 → 65
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:91 → 352
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  5. XM_006508036.3 → XP_006508099.1  inactive carboxypeptidase-like protein X2 isoform X4

    Conserved Domains (3) summary
    cd11308
    Location:416 → 491
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:1 → 65
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd03869
    Location:91 → 412
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2L5.1 GenPept UniProtKB/Swiss-Prot:Q9D2L5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous